363 Result(s)
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Article
Interon-gamma enhances the antitumor effect of all-trans retinoic acid on hepatocellular carcinoma cells by inhibiting the expression of nuclear factor-kappaB
To explore the combination effects of all-trans retinoic acid (ATRA) with interferon-gamma (IFN-γ) on human hepatocarcinoma cell line SMMC-7721 and the mechanism of action.
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Article
Open AccessIncreased expression of heat shock protein 105 in rat uterus of early pregnancy and its significance in embryo implantation
Heat shock proteins (Hsps) are a set of highly conserved proteins, Hsp105, has been suggested to play a role in reproduction.
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Article
The prevalence of PALB2 germline mutations in BRCA1/BRCA2 negative Chinese women with early onset breast cancer or affected relatives
PALB2 has been recently identified as breast cancer susceptibility gene in western populations. To investigate the contribution of PALB2 mutations to Chinese non-BRCA1/BRCA2 hereditary breast cancer, we screen...
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Article
Duodenal heterotopic pancreas in a child
Heterotopic pancreas is characterized by pancreatic tissue outside the pancreatic bed. However, duodenal heterotopic pancreas in children is rarely reported so far. We describe herein duodenal heterotopic panc...
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Article
Mutation analysis of BRIP1/BACH1 in BRCA1/BRCA2 negative Chinese women with early onset breast cancer or affected relatives
The proper interaction between BRIP1/BACH1 and BRCA1 protein has been found to be crucial for BRCA1-mediated DNA double-strand break repair and BRIP1/BACH1 mutations were estimated to confer a relative risk fo...
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Article
Effect of Jianpi Huoxue decoction (健脾活血方)-containing serum on tumor necrosis factor-α secretion and gene Expression of endotoxin receptors in RAW264.7 cells induced by lipopolysaccharide
To evaluate the effect of Jianpi Huoxue decoction (健脾活血方, JHD)-containing serum on tumor necrosis factor-α (TNF-α) secretion and endotoxin receptor gene expression in RAW264.7 cells induced by lipopolysacchari...
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Article
Langerhans’ cell histiocytosis of the spine in children with soft tissue extension and chemotherapy
The objectives of this paper were to look into the possible incidence of obvious soft tissue extension from Langerhans’ cell histiocytosis (LCH) of the spine in children and to evaluate the effects of chemothe...
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Article
Identification of a novel GNAS mutation for pseudohypoparathyroidism in a Chinese family
Pseudohypoparathyroidism (PHP) is a heterogeneous group of diseases characterized by hormone resistance to receptors that stimulate adenylate cyclase. PHP-Ia patients show specific Gs-alpha protein deficiency,...
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Article
Expression and clinical significance of heparanase in neuroblastoma
Previous studies indicate that heparanase (HPA), an endoglycosidase involved in tumor angiogenesis and metastasis, is up-regulated in a variety of malignancies. However, the expression of HPA in neuroblastoma ...
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Article
Trans-upper-sternal Approach to the Cervicothoracic Junction
From August 1999 to February 2006, 11 patients with cervicothoracic lesions (eight males, three females; age range, 17–77 years) were surgically treated using the trans-upper-sternal approach. Combined cervico...
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Article
The angiogenic and prognostic implications of VEGF, Ang-1, Ang-2, and MMP-9 for hepatocellular carcinoma with background of hepatitis B virus
The objective of this study was to investigate the expressions of angiogenic factors and elucidate their angiogenic and prognostic roles in hepatocellular carcinoma (HCC) with background of hepatitis B virus (...
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Article
Cediranib (recentin, AZD2171) reverses ABCB1- and ABCC1-mediated multidrug resistance by inhibition of their transport function
Cediranib (recentin, AZD2171) is an oral small-molecule multiple receptor tyrosine kinases inhibitor. Here we investigate the ability of cediranib to reverse tumor multidrug resistance (MDR) due to overexpress...
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Article
PNAS-4, a novel pro-apoptotic gene, can potentiate antineoplastic effects of cisplatin
PNAS-4, a novel pro-apoptotic gene activated during the early response to DNA damage, can inhibit proliferation via apoptosis when overexpressed in some tumor cells. The objectives of this study were to determ...
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Article
The number and function of circulating endothelial progenitor cells in patients with Kawasaki disease
Kawasaki disease (KD) is associated with coronary artery injury. Studies have shown that the endothelial progenitor cell (EPC) participates in the process of arterial repair. Data have been reported that the n...
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Article
Significance of Serum Connective Tissue Growth Factor in Patients with Hepatocellular Carcinoma and Relationship with Angiogenesis
Connective tissue growth factor (CTGF) expression changes variously in different human malignancies. The role of CTGF in hepatocellular carcinoma (HCC) is still not clear. The purpose of this study was to inve...
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Article
BMI, disease activity, and health-related quality-of-life in systemic lupus erythematosus
The aim of this study was to examine the independent and interactive associations among body mass index (BMI), disease activity, on health-related quality-of-life (HRQoL) in Chinese patients with systemic lupu...
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Article
Research progress on the mechanism of single-Chinese medicinal herbs in treating diabetes mellitus
Treating diabetes mellitus (DM) with Chinese medicine (CM) has had a few thousands years of history. Past Chinese medical texts had already recorded numerous medicinal herbs as well as recipes for treating DM ...
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Article
Incidence and mortality trend of cervical cancer in 11 cancer registries of China
In many countries, the cervical cancer prevalence has declined but less information about the changes is available in China. This study aims to understand the epidemiological characteristics and trend of cervi...
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Article
Association between mitogen-activated protein kinase kinase kinase 1 rs889312 polymorphism and breast cancer risk: evidence from 59,977 subjects
Published data on the association between mitogen-activated protein kinase kinase kinase 1 (MAP3K1) gene rs889312 polymorphism and breast cancer risk are inconclusive. To derive a more precise estimation of th...
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Article
The prognostic significance of TP53 mutations in Chinese patients with chronic lymphocytic leukemia is independent of del(17p13)
The poor prognosis of chronic lymphocytic leukemia (CLL) patients with del(17p13) is well established. Several studies have shown that cases with TP53 mutations and TP53 mutations without del(17p13) may be adv...
