39 Result(s)

Article

Tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia: a single-institution experience

Patients with CML treated with TKI can have a life expectancy comparable to that of the general population. Due to the extended duration of TKI administration, treatment discontinuation has been increasingly s...

Kamal Chamoun, Hagop Kantarjian, Rami Atallah… in Journal of Hematology & Oncology (2019)

Article

Hundreds of genetic barcodes of the species-rich hydroid superfamily Plumularioidea (Cnidaria, Medusozoa) provide a guide toward more reliable taxonomy

Marine hydroids are important benthic components of shallow and deep waters worldwide, but their taxonomy is controversial because diagnostic morphological characters to categorize taxa are limited. Their gene...

Carlos J. Moura, Harilaos Lessios, Jorge Cortés, Martha S. Nizinski… in Scientific Reports (2018)

Article

Phase I studies of AZD1208, a proviral integration Moloney virus kinase inhibitor in solid and haematological cancers

Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are overexpressed in several tumour types and contribute to oncogenesis. AZD1208 is a potent ATP-competitive PIM kinase inhibitor investigated i...

Jorge Cortes, Kenji Tamura, Daniel J. DeAngelo, Johann de Bono… in British Journal of Cancer (2018)

Article

Design and rationale for the life after stop** tyrosine kinase inhibitors (LAST) study, a prospective, single-group longitudinal study in patients with chronic myeloid leukemia

Treatment of chronic myeloid leukemia with a tyrosine kinase inhibitor (TKI) offers significant improvements over previous treatments in terms of survival and toxicity yet nevertheless is associated with reduc...

Ehab Atallah, Charles A. Schiffer, Kevin P. Weinfurt, Mei-Jie Zhang… in BMC Cancer (2018)

Article

Long-term effects of ruxolitinib versus best available therapy on bone marrow fibrosis in patients with myelofibrosis

Myelofibrosis (MF) is a life-shortening complication of myeloproliferative neoplasms associated with ineffective hematopoiesis, splenomegaly, and progressive bone marrow (BM) fibrosis. The oral Janus kinase (J...

Hans Michael Kvasnicka, Jürgen Thiele… in Journal of Hematology & Oncology (2018)

Article

A Phase II Study of Arginine Deiminase (ADI-PEG20) in Relapsed/Refractory or Poor-Risk Acute Myeloid Leukemia Patients

Exogenous arginine is required for growth in some argininosuccinate synthetase (ASS)-deficient cancers. Arginine deiminase (ADI) inhibits growth in various ASS-deficient cancers by depleting arginine. The effi...

Hui-Jen Tsai, Shih Sheng Jiang, Wen-Chun Hung, Gautam Borthakur… in Scientific Reports (2017)

Article

Evaluation of cardiovascular ischemic event rates in dasatinib-treated patients using standardized incidence ratios

With high survival rates for chronic myeloid leukemia (CML) patients treated with BCR-ABL1 tyrosine kinase inhibitors (TKIs), emerging consequences, such as arterial ischemic events, require consideration when...

Giuseppe Saglio, Philipp le Coutre, Jorge Cortes, Jiří Mayer… in Annals of Hematology (2017)

Article

The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of hematologic malignancies: multiple myeloma, lymphoma, and acute leukemia

Increasing knowledge concerning the biology of hematologic malignancies as well as the role of the immune system in the control of these diseases has led to the development and approval of immunotherapies that...

Michael Boyiadzis, Michael R. Bishop, Rafat Abonour… in Journal for ImmunoTherapy of Cancer (2016)

Article

Effect of treatment with a JAK2-selective inhibitor, fedratinib, on bone marrow fibrosis in patients with myelofibrosis

Progressive bone marrow fibrosis (BMF) is a cardinal feature of many myeloproliferative neoplasms (MPNs) and there is a documented association between the severity of BMF and overall prognosis. We conducted an...

Catriona Jamieson, Robert Hasserjian, Jason Gotlib… in Journal of Translational Medicine (2015)

Article

Clinical features of De Novo acute myeloid leukemia with concurrent DNMT3A, FLT3 and NPM1 mutations

De novo acute myeloid leukemia (AML) with concurrent DNMT3A, FLT3 and NPM1 mutations (AML ^{DNMT3A/FLT3/NPM1} ) has been suggested to represent a unique AML subset on the basis ...

Sanam Loghavi, Zhuang Zuo, Farhad Ravandi… in Journal of Hematology & Oncology (2014)

Article

Diet of the sea anemone Anthopleura nigrescens: composition and variation between daytime and nighttime high tides

The diverse feeding habits of sea anemones have led them to be classified as opportunistic polyphagous predators. However, most studies have focused on the diet of temperate sea anemones, and little is known a...

Andrés J Quesada, Fabián H Acuña, Jorge Cortés in Zoological Studies (2014)

Article

Optimizing management of ruxolitinib in patients with myelofibrosis: the need for individualized dosing

Ruxolitinib, an oral JAK1 and JAK2 inhibitor, is approved in the US for patients with intermediate or high-risk myelofibrosis (MF), a chronic neoplasm associated with aberrant myeloproliferation, progressive b...

Ruben A Mesa, Jorge Cortes in Journal of Hematology & Oncology (2013)

Article

Analysis of the potential effect of ponatinib on the QTc interval in patients with refractory hematological malignancies

Cardiac dysfunction, particularly QT interval prolongation, has been observed with tyrosine kinase inhibitors approved to treat chronic myeloid leukemia. This study examines the effects of ponatinib on cardiac...

Daryl Sonnichsen, David J. Dorer, Jorge Cortes… in Cancer Chemotherapy and Pharmacology (2013)

Article

Erratum: Janus kinase inhibitors for the treatment of myeloproliferative neoplasias and beyond

Nature Reviews Drug Discovery 10, 127–140 (2011) The information presented in Table 2 on the compound SB1518 was incorrect; the correct information is provided below, and has been corrected online.

Alfonso Quintás-Cardama, Hagop Kantarjian, Jorge Cortes… in Nature Reviews Drug Discovery (2011)

Article

Distributed Motion Constraints for Algebraic Connectivity of Robotic Networks

This paper studies connectivity maintenance of robotic networks that communicate at discrete times and move in continuous space. We propose a distributed coordination algorithm that allows the robots to decide...

Michael Schuresko, Jorge Cortés in Journal of Intelligent and Robotic Systems (2009)

Article

Exploring Landmark Placement Strategies for Topology-Based Localization in Wireless Sensor Networks

In topology-based localization, each node in a network computes its hop-count distance to a finite number of reference nodes, or "landmarks". This paper studies the impact of landmark placement on the accuracy...

Farid Benbadis, Katia Obraczka, Jorge Cortés… in EURASIP Journal on Advances in Signal Proc… (2007)

Article

In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate'

Ehab Atallah, Hagop Kantarjian, Jorge Cortes in Nature Medicine (2007)

Article

Incidence of hip fractures in Salamanca, Spain. Period: 1994–2002

The incidence of hip fractures in Salamanca (Spain) has been lower than in other countries, but has shown a marked increase during the past few decades. The aim of this work is to ascertain the real incidence ...

Juan F. Blanco, Agustin Díaz-Alvarez, Jose A. De Pedro… in Archives of Osteoporosis (2006)

Article

Science powerhouse of Central America

Jorge Cortés in Nature (1999)