487 Result(s)

Article

Toripalimab plus capecitabine in the treatment of patients with residual nasopharyngeal carcinoma: a single-arm phase 2 trial

Patients with residual nasopharyngeal carcinoma after receiving definitive treatment have poor prognoses. Although immune checkpoint therapies have achieved breakthroughs for treating recurrent and metastatic ...

Xun Cao, Hao-Yang Huang, Chi-**ong Liang, Zhuo-Chen Lin… in Nature Communications (2024)

Article

Molecular mechanisms underlying the BIRC6-mediated regulation of apoptosis and autophagy

Procaspase 9 is the initiator caspase for apoptosis, but how its levels and activities are maintained remains unclear. The gigantic Inhibitor-of-Apoptosis Protein BIRC6/BRUCE/Apollon inhibits both apoptosis an...

Shuo-Shuo Liu, Tian-**a Jiang, Fan Bu, Ji-Lan Zhao, Guang-Fei Wang… in Nature Communications (2024)

Article

Monitoring of urinary iodine concentration in naval pilots: should iodine be supplemented or limited at coastal stations?

Jia Zeng, Qi Li, **ang Lu, Dan-Dan Liu, Rong-Guan Jiao… in Military Medical Research (2024)

Article

A nitrous oxide/oxygen fixed mixture to reduce pain induced by the hypodermic injection: study protocol for a randomized, controlled trial

Patients with hematological malignancies received multiple hypodermic injections of recombinant human granulocyte colony-stimulating factor. Procedural pain is one of the most common iatrogenic causes of pain ...

Jun-Jun Zhang, ** Yu, Hui Dang, Cheng-Shuang Feng, **u-Jiang Long, Wen-Fa Huang… in Trials (2024)

Article

Optimal dilation duration of 10 mm diameter balloons after limited endoscopic sphincterotomy for common bile duct stones: a randomized controlled trial

Limited endoscopic sphincterotomy (EST) combined with endoscopic papillary balloon dilation (EPBD) is widely used. However, the optimal duration of small balloon dilation in choledocholithiasis remains controv...

Yuan-Yuan Li, Yin-Shui Miao, Cai-Feng Wang, **g Yan, **ao-Jiang Zhou… in Scientific Reports (2024)

Article

Inhibition of STAT3 alleviates LPS-induced apoptosis and inflammation in renal tubular epithelial cells by transcriptionally down-regulating TASL

Systemic lupus erythematosus (SLE) is a common autoimmune disease that impacts various organs. Lupus nephritis (LN) significantly contributes to death in children with SLE. Toll-like receptor (TLR) adaptor int...

**-Wen Xu, Ming-Yan Wang, Yan Mao, Zheng-Yun Hu… in European Journal of Medical Research (2024)

Article

Advances in nuclear detection and readout techniques

“A Craftsman Must Sharpen His Tools to Do His Job,” said Confucius. Nuclear detection and readout techniques are the foundation of particle physics, nuclear physics, and particle astrophysics to reveal the nat...

Rui He, **ao-Yang Niu, Yi Wang, Hong-Wei Liang… in Nuclear Science and Techniques (2023)

Article

Comprehensive genomic profiling of breast cancers characterizes germline-somatic mutation interactions mediating therapeutic vulnerabilities

Germline-somatic mutation interactions are universal and associated with tumorigenesis, but their role in breast cancer, especially in non-Caucasians, remains poorly characterized. We performed large-scale pro...

Chao Chen, Cai-** Lin, Yu-Chen Pei, Ding Ma, Li Liao, Si-Yuan Li… in Cell Discovery (2023)

Article

DPY30 promotes colorectal carcinoma metastasis by upregulating ZEB1 transcriptional expression

DPY30 belongs to the core subunit of components of the histone lysine methyltransferase complex, which is implicated in tumorigenesis, cell senescence, and other biological events. However, its contribution to...

Chun-Ying Luo, Wei-Chao Su, Hai-Feng Jiang, Ling-Tao Luo… in Cancer Cell International (2023)

Article

Search for physics beyond the standard model in top quark production with additional leptons in the context of effective field theory

A search for new physics in top quark production with additional final-state leptons is performed using data collected by the CMS experiment in proton-proton collisions at

A. Hayrapetyan, A. Tumasyan, W. Adam, J. W. Andrejkovic… in Journal of High Energy Physics (2023)

Article

Tumor-targeting hydroxyapatite nanoparticles for remodeling tumor immune microenvironment (TIME) by activating mitoDNA-pyroptosis pathway in cancer

In recent years, immunotherapy has emerged as a promising strategy for treating solid tumors, although its efficacy remains limited to a subset of patients. Transforming non-responsive “cold” tumor types into ...

Yuxuan Yang, Jia Yang, Nan Zhu, Haosen Qiu, Wenxiang Feng… in Journal of Nanobiotechnology (2023)

Article

Erratum to: ARID1A Inactivation Increases Expression of circ0008399 and Promotes Cisplatin Resistance in Bladder Cancer

Yang-kai Jiang, Yu-jun Shuai, Hua-min Ding, Hui Zhang… in Current Medical Science (2023)

Article

Oral pathogens exacerbate Parkinson’s disease by promoting Th1 cell infiltration in mice

Parkinson’s disease (PD) is a common chronic neurological disorder with a high risk of disability and no cure. Periodontitis is an infectious bacterial disease occurring in periodontal supporting tissues. Stud...

Xue-Bing Bai, Shuo Xu, Lu-Jun Zhou, **ao-Qian Meng, Yu-Lin Li, Yan-Lin Chen… in Microbiome (2023)

Article

RhoA suppresses pseudorabies virus replication in vitro

The porcine pseudorabies virus (PRV) is one of the most devastating pathogens and brings great economic losses to the swine industry worldwide. Viruses are intracellular parasites that have evolved numerous st...

**n-Man Li, Shi-** Wang, **-Yuan Wang, Ting Tang, Bo Wan, Lei Zeng… in Virology Journal (2023)

Article

Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients

The Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infected a substantial proportion of Chinese population, and understanding the factors underlying the severity of the dis...

Lin Wang, Jia-Bao Cao, Bin-Bin **a, Yue-Juan Li… in Signal Transduction and Targeted Therapy (2023)

Article

Genetic diversity of field Fusarium asiaticum and Fusarium graminearum isolates increases the risk of fungicide resistance

Fusarium head blight (FHB) caused by Fusarium species, seriously threatens the safety of wheat (Triticum aestivum) production. Resistant cultivars and fungicides are frequently used to control these FHB pathogens...

Ya-Zhou Zhang, Zhuo Li, Jie Man, Dan Xu, Lan Wen, Chen Yang… in Phytopathology Research (2023)

Article

Association between depression and endometriosis using data from NHANES 2005–2006

Studies on the association between depression and self-reported endometriosis are limited, and further studies are required to investigate this association. Data were collected from the National Health and Nut...

Pan-Wei Hu, **ao-Le Zhang, **ao-Tong Yan, Cong Qi, Guo-**g Jiang in Scientific Reports (2023)

Article

Uncovering neural pathways underlying bulimia nervosa: resting-state neural connectivity disruptions correlate with maladaptive eating behaviors

Bulimia nervosa (BN) is characterized by recurrent binge-eating episodes and inappropriate compensatory behaviors. This study investigated alterations in resting-state surface-based neural activity in BN patie...

Jia-ni Wang, Miao Wang, Guo-wei Wu… in Eating and Weight Disorders - Studies on A… (2023)

Article

The pseudoenzyme ADPRHL1 affects cardiac function by regulating the ROCK pathway

Pseudoenzymes, catalytically deficient variants of active enzymes, have a wide range of regulatory functions. ADP-ribosylhydrolase-like 1 (ADPRHL1), a pseudoenzyme belonging to a small group of ADP-ribosylhydr...

Lei Tian, Tianwei Guo, Fujian Wu, Rui Bai, Sinan Ai… in Stem Cell Research & Therapy (2023)

Article

Expanding causal genes for Parkinson’s disease via multi-omics analysis

Genome‑wide association studies (GWASs) have revealed numerous loci associated with Parkinson’s disease (PD). However, some potential causal/risk genes were still not revealed and no etiological therapies are ...

**ao-**g Gu, Wei-Ming Su, Meng Dou, Zheng Jiang, Qing-Qing Duan… in npj Parkinson's Disease (2023)