45 Result(s)

Article

A novel missense variant in ACAA1 contributes to early-onset Alzheimer’s disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline

Alzheimer’s disease (AD) is characterized by progressive synaptic dysfunction, neuronal death, and brain atrophy, with amyloid-β (Aβ) plaque deposits and hyperphosphorylated tau neurofibrillary tangle accumula...

Rongcan Luo, Yu Fan, **g Yang, Maosen Ye… in Signal Transduction and Targeted Therapy (2021)

Article

CD147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression

Major gaps in understanding the molecular mechanisms of colorectal cancer (CRC) progression and intestinal mucosal repair have hampered therapeutic development for gastrointestinal disorders. Trefoil factor 3 ...

Hong-Yong Cui, Shi-Jie Wang, Fei Song, Xu Cheng… in Signal Transduction and Targeted Therapy (2021)

Article

TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca²⁺/CaMKII/Nrf2 signaling pathway

Osteoarthritis (OA) is the major course of joint deterioration, in which M1 macrophage-driven synovitis exacerbates the pathological process. However, precise therapies for M1 macrophage to decrease synovitis ...

Zhongyang Lv, **ngquan Xu, Ziying Sun, Yannick **aofan Yang, Hu Guo… in Cell Death & Disease (2021)

Article

Notch3 inhibits cell proliferation and tumorigenesis and predicts better prognosis in breast cancer through transactivating PTEN

Notch receptors (Notch1–4) play critical roles in tumorigenesis and metastasis of malignant tumors, including breast cancer. Although abnormal Notch activation is related to various tumors, the importance of s...

Yong-Qu Zhang, Yuan-Ke Liang, Yang Wu, Min Chen, Wei-Ling Chen… in Cell Death & Disease (2021)

Article

Author Correction: N⁶-methyladenine is incorporated into mammalian genome by DNA polymerase

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

**aoling Liu, Weiyi Lai, Yao Li, Shaokun Chen, Baodong Liu, Ning Zhang… in Cell Research (2021)

Article

New genotypes of Helicobacter Pylori VacA d-region identified from global strains

Pathogenesis of Helicobacter Pylori (HP) vacuolating toxin A (vacA) depends on polymorphic diversity within the signal (s), middle (m), intermediate (i), deletion (d) and c-regions. These regions show distinct al...

Djaleel Muhammad Soyfoo, Yussriya Hanaa Doomah, Dong Xu… in BMC Molecular and Cell Biology (2021)

Article

N⁶-methyladenine is incorporated into mammalian genome by DNA polymerase

**aoling Liu, Weiyi Lai, Yao Li, Shaokun Chen, Baodong Liu, Ning Zhang… in Cell Research (2021)

Article

The YY1/miR-548t-5p/CXCL11 signaling axis regulates cell proliferation and metastasis in human pancreatic cancer

Pancreatic cancer (PC) is a malignant tumor with a poor prognosis and high mortality. However, the biological role of miR-548t-5p in PC has not been reported. In this study, we found that miR-548t-5p expressio...

Wan-Li Ge, Qun Chen, Ling-Dong Meng, Xu-Min Huang, Guo-dong Shi… in Cell Death & Disease (2020)

Article

Role of the PPAR pathway in atrial fibrillation associated with heart valve disease: transcriptomics and proteomics in human atrial tissue

Huan-**n Chen, Ming-Yang Li, Yi-Yao Jiang… in Signal Transduction and Targeted Therapy (2020)

Article

Down-regulation of miR-29c is a prognostic biomarker in acute myeloid leukemia and can reduce the sensitivity of leukemic cells to decitabine

MicroRNA-29c (miR-29c) is abnormally expressed in several cancers and serves as an important predictor of tumor prognosis. Herein, we investigate the effects of abnormal miR-29c expression and analyze its clin...

Li-juan Tang, Guo-kang Sun, Ting-juan Zhang, De-hong Wu… in Cancer Cell International (2019)

Article

Diverse regulatory manners of human telomerase reverse transcriptase

Human telomerase reverse transcriptase (hTERT) is the core subunit of human telomerase and plays important roles in human cancers. Aberrant expression of hTERT is closely associated with tumorigenesis, cancer ...

Meng-Meng Jie, **ng Chang, Shuo Zeng, Cheng Liu… in Cell Communication and Signaling (2019)

Article

Regulation of the master regulator FOXM1 in cancer

FOXM1 (forkhead box protein M1) is a critical proliferation-associated transcription factor that is widely spatiotemporally expressed during the cell cycle. It is closely involved with the processes of cell pr...

Guo-Bin Liao, **n-Zhe Li, Shuo Zeng, Cheng Liu… in Cell Communication and Signaling (2018)

Article

The long non-coding RNA AK001796 contributes to tumor growth via regulating expression of p53 in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is one of the prevalent and deadly cancers worldwide, especially in China. Considering the poor prognosis of ESCC, the aim of this study is to dissect the effects of l...

Bin Liu, Chun-Feng Pan, Guo-Liang Yao, Ke Wei, Yang **a… in Cancer Cell International (2018)

Article

SLIT2/ROBO1 axis contributes to the Warburg effect in osteosarcoma through activation of SRC/ERK/c-MYC/PFKFB2 pathway

Cellular metabolic reprogramming is the main characteristic of cancer cells and identification of targets using this metabolic pattern is extremely important to treat cancers, such as osteosarcoma (OS). In thi...

Shu-Jie Zhao, Yi-Fei Shen, Qing Li, Yun-Jie He, Yun-Kun Zhang… in Cell Death & Disease (2018)

Article

MiR-539 inhibits proliferation and migration of triple-negative breast cancer cells by down-regulating LAMA4 expression

Recent studies have shown that laminin subunit alpha 4 (LAMA4) plays an important role in carcinogenesis. However, its molecular biological function in triple-negative breast cancer (TNBC) has not been entirel...

Zhi-Xue Yang, Bo Zhang, **rong Wei, Guo-Qin Jiang, Yan-Lin Wu… in Cancer Cell International (2018)

Article

Elimination of stem-like cancer cell side-population by auranofin through modulation of ROS and glycolysis

Cancer side-population (SP) represents a sub-population of stem-like cancer cells that have an important role in drug resistance due to their high expression of the ATP-binding cassette transporter ABCG2 invol...

Guo-**n Hou, Pan-Pan Liu, Shengyi Zhang, Mengqi Yang, Jianwei Liao… in Cell Death & Disease (2018)

Article

H19/let-7/LIN28 reciprocal negative regulatory circuit promotes breast cancer stem cell maintenance

Long noncoding RNA-H19 (H19), an imprinted oncofetal gene, has a central role in carcinogenesis. Hitherto, the mechanism by which H19 regulates cancer stem cells, remains elusive. Here we show that breast cancer ...

Fei Peng, Ting-Ting Li, Kai-Li Wang, Guo-Qing **ao, Ju-Hong Wang… in Cell Death & Disease (2018)

Article

Erratum: A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations

Correction to: Cell Research (2017) 27:386–401. doi:10.1038/cr.2017.17; published online on 27 January 2017 The authors apologized for the mistake of mis-labeling the affiliation for Dr Stuart H Orkin, his aff...

** Han, Hao Yu, Daosheng Huang, Yang Xu, Assieh Saadatpour, **a Li… in Cell Research (2017)

Article

Erratum: A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations

Correction to: Cell Research (2017) 27:386–401. doi:10.1038/cr.2017.17; published online on 27 January 2017 During web production, there is an error in the web site for the labeling of Dr Bin Zhou, his affilia...

** Han, Hao Yu, Daosheng Huang, Yang Xu, Assieh Saadatpour, **a Li… in Cell Research (2017)

Article

A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations

Recent advances have demonstrated the power of small molecules in promoting cellular reprogramming. Yet, the full potential of such chemicals in cell fate manipulation and the underlying mechanisms require fur...

** Han, Hao Yu, Daosheng Huang, Yang Xu, Assieh Saadatpour, **a Li… in Cell Research (2017)