77 Result(s)

Article

Discovery of new genetic loci for male sexual orientation in Han population

Epidemiological studies have demonstrated that the genetic factors partly influence the development of same-sex sexual behavior, but most genetic studies have focused on people of primarily European ancestry, ...

Shao-Hua Hu, Hai-mei Li, Hao Yu, Yan Liu, Chen-**ng Liu, **an-bo Zuo… in Cell Discovery (2021)

Article

A negative feedback loop involving NF-κB/TIR8 regulates IL-1β-induced epithelial- myofibroblast transdifferentiation in human tubular cells

Renal tubular epithelial-myofibroblast transdifferentiation (EMT) plays a central role in the development of renal interstitial fibrosis (RIF). The profibrotic cytokine interleukin (IL)-1 and the IL-1 receptor...

Keguo Jiang, Yuying Zhang, Fan He… in Journal of Cell Communication and Signaling (2021)

Article

Selection of functional EPHB2 genotypes from ENU mutated grass carp treated with GCRV

N-ethyl-N-nitrosourea (ENU) mutagenesis is a useful method for the genetic engineering of plants, and the production of functional mutants in animal models including mice and zebrafish. Grass carp reovirus (GCRV)...

Meher un Nissa, Zhu-**ang Jiang, Guo-Dong Zheng, Shu-Ming Zou in BMC Genomics (2021)

Article

Wolfberry genomes and the evolution of Lycium (Solanaceae)

Wolfberry Lycium, an economically important genus of the Solanaceae family, contains approximately 80 species and shows a fragmented distribution pattern among the Northern and Southern Hemispheres. Although seve...

You-Long Cao, Yan-long Li, Yun-Fang Fan, Zhen Li, Kouki Yoshida… in Communications Biology (2021)

Article

TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca²⁺/CaMKII/Nrf2 signaling pathway

Osteoarthritis (OA) is the major course of joint deterioration, in which M1 macrophage-driven synovitis exacerbates the pathological process. However, precise therapies for M1 macrophage to decrease synovitis ...

Zhongyang Lv, **ngquan Xu, Ziying Sun, Yannick **aofan Yang, Hu Guo… in Cell Death & Disease (2021)

Article

Notch3 inhibits cell proliferation and tumorigenesis and predicts better prognosis in breast cancer through transactivating PTEN

Notch receptors (Notch1–4) play critical roles in tumorigenesis and metastasis of malignant tumors, including breast cancer. Although abnormal Notch activation is related to various tumors, the importance of s...

Yong-Qu Zhang, Yuan-Ke Liang, Yang Wu, Min Chen, Wei-Ling Chen… in Cell Death & Disease (2021)

Article

Genome wide analysis of kinesin gene family in Citrullus lanatus reveals an essential role in early fruit development

Kinesin (KIN) as a motor protein is a versatile nano-machine and involved in diverse essential processes in plant growth and development. However, the kinesin gene family has not been identified in watermelon,...

Shujuan Tian, Jiao Jiang, Guo-qi Xu, Tan Wang, Qiyan Liu, **ner Chen… in BMC Plant Biology (2021)

Article

Author Correction: N⁶-methyladenine is incorporated into mammalian genome by DNA polymerase

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

**aoling Liu, Weiyi Lai, Yao Li, Shaokun Chen, Baodong Liu, Ning Zhang… in Cell Research (2021)

Article

New genotypes of Helicobacter Pylori VacA d-region identified from global strains

Pathogenesis of Helicobacter Pylori (HP) vacuolating toxin A (vacA) depends on polymorphic diversity within the signal (s), middle (m), intermediate (i), deletion (d) and c-regions. These regions show distinct al...

Djaleel Muhammad Soyfoo, Yussriya Hanaa Doomah, Dong Xu… in BMC Molecular and Cell Biology (2021)

Article

N⁶-methyladenine is incorporated into mammalian genome by DNA polymerase

**aoling Liu, Weiyi Lai, Yao Li, Shaokun Chen, Baodong Liu, Ning Zhang… in Cell Research (2021)

Article

The YY1/miR-548t-5p/CXCL11 signaling axis regulates cell proliferation and metastasis in human pancreatic cancer

Pancreatic cancer (PC) is a malignant tumor with a poor prognosis and high mortality. However, the biological role of miR-548t-5p in PC has not been reported. In this study, we found that miR-548t-5p expressio...

Wan-Li Ge, Qun Chen, Ling-Dong Meng, Xu-Min Huang, Guo-dong Shi… in Cell Death & Disease (2020)

Article

A simple and rapid protein purification method based on cell-surface display of SUMO-fused recombinant protein and Ulp1 protease

The development of novel methods for highly efficient protein purification remains a research focus in the biotechnology field because conventional purification approaches, including affinity purification, gel...

**ao-Feng Zhou, Chen-Lu Zhang, Xue-** Gao, Wei-Long Wang, Zheng-Fen He… in AMB Express (2020)

Article

Map** of QTLs for source and sink associated traits under elevated CO₂ in rice (Oryza sativa L.)

Rice source- and sink-associated traits are important for grain yield and are sensitive to environmental conditions. The continuing increase of CO₂ concentrations in the atmosphere will become a major challenge f...

Li-** Dai, Xue-Li Lu, Wei-Wei Zou, Chang-Jian Wang, Lan Shen… in Plant Growth Regulation (2020)

Article

Associations between GUCY1A3 genetic polymorphisms and large artery atherosclerotic stroke risk in Chinese Han population: a case-control study

Previous genome-wide association studies have found two single nucleotide polymorphisms (SNP) rs7692387 and rs1842896 located on or near the GUCY1A3 gene were associated with coronary artery disease (CAD). GUCY1A...

Jian-li Li, Liu-yu Liu, Dong-dong Jiang, Yi-ying Jiang… in Lipids in Health and Disease (2019)

Article

New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata

Two hitherto unknown iboga-type indole alkaloids, namely (3R)-7,19-di-epi-3-methoxytabernoxidine (1) and (3R,19R)-19-hydroxy-3-(2-oxopropyl)voacangine (2), together with eight known alkaloids (3–10), were isolate...

**ang-Mei Li, **an-Jun Jiang, Guo-Zhu Wei… in Natural Products and Bioprospecting (2019)

Article

Soil pH is the primary factor driving the distribution and function of microorganisms in farmland soils in northeastern China

To understand which environmental factors influence the distribution and ecological functions of bacteria in agricultural soil.

Cheng-yu Wang, Xue Zhou, Dan Guo, Jiang-hua Zhao, Li Yan… in Annals of Microbiology (2019)

Article

Identification of differentially expressed genes and pathways between intramuscular and abdominal fat-derived preadipocyte differentiation of chickens in vitro

The distribution and deposition of fat tissue in different parts of the body are the key factors affecting the carcass quality and meat flavour of chickens. Intramuscular fat (IMF) content is an important fact...

Meng Zhang, Fang Li, **ang-fei Ma, Wen-ting Li, Rui-rui Jiang, Rui-li Han… in BMC Genomics (2019)

Article

Dissection of the Genetic Architecture of Rice Tillering using a Genome-wide Association Study

Rice tiller number (TN) is one of the most important components associated with rice grain yield. Around one hundred rice TN genes have been identified, but dissecting the genetic architecture of rice TN varia...

Su Jiang, Dan Wang, Shuangyong Yan, Shiming Liu, Bin Liu, Houxiang Kang… in Rice (2019)

Article

Diverse regulatory manners of human telomerase reverse transcriptase

Human telomerase reverse transcriptase (hTERT) is the core subunit of human telomerase and plays important roles in human cancers. Aberrant expression of hTERT is closely associated with tumorigenesis, cancer ...

Meng-Meng Jie, **ng Chang, Shuo Zeng, Cheng Liu… in Cell Communication and Signaling (2019)

Article

Transcriptional reference map of hormone responses in wheat spikes

Phytohormones are key regulators of plant growth, development, and signalling networks involved in responses to diverse biotic and abiotic stresses. Transcriptional reference maps of hormone responses have bee...

Peng-Fei Qi, Yun-Feng Jiang, Zhen-Ru Guo, Qing Chen, Thérèse Ouellet… in BMC Genomics (2019)