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The validity of cost-effectiveness analyses of tight glycemic control. A systematic survey of economic evaluations of pharmacological interventions in patients with type 2 diabetes
Currently available randomized trial evidence has shown no reductions in type 2 diabetes (T2D) complications important to patients with tight glycemic control. Yet, economic analyses consistently find tight gl...
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Open AccessFeasibility of behavioral activation group therapy in reducing depressive symptoms and improving quality of life in patients with depression: the BRAVE pilot trial
Depression impacts the lives of millions of people worldwide. Behavioral activation (BA), derived from cognitive behavioral therapy, has the potential for improving depressive symptoms in patients with depress...
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Guidelines seek unbiased recommendations
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Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine
To develop evidence-based clinical practice recommendations regarding transfusion practices in non-bleeding, critically ill adults.
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Open AccessPredictors of 1-year mortality in adult lung transplant recipients: a systematic review and meta-analysis
Upon surviving the first year post-lung transplantation, recipients can expect a median survival of 8 years. Within the first year, graft failure and multi-organ failure (possibly secondary to graft failure) a...
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Factors influencing decision making in neonatology: inhaled nitric oxide in preterm infants
We studied decision making regarding inhaled nitric oxide (iNO) in preterm infants with Pulmonary Hypertension (PH).
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Conflicts of interest disclosure forms and management in critical care clinical practice guidelines
Trustworthy clinical practice guidelines (CPGs) require identification and careful management of conflicts of interest (COIs) among all participants in the guideline development. Furthermore, COIs are more com...
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Open AccessNetwork meta-analysis: users’ guide for pediatricians
Network meta-analysis (NMA) is a powerful analytic tool that allows simultaneous comparison between several management/treatment alternatives even when direct comparisons of the alternatives (such as the case ...
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Open AccessThe GRADE Evidence to Decision (EtD) framework for health system and public health decisions
To describe a framework for people making and using evidence-informed health system and public health recommendations and decisions.
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Open AccessPublic health journals’ requirements for authors to disclose funding and conflicts of interest: a cross-sectional study
Public health journals need to have clear policies for reporting the funding of studies and authors’ personal financial and non-financial conflicts of interest (COI) disclosures. This study aims to assess the ...
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Are systematic reviews and meta-analyses still useful research? Yes
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Target blood pressure for septic and vasodilatory shock: what is optimal?
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Correction to: Efficacy and safety of stress ulcer prophylaxis in critically ill patients: a network meta-analysis of randomized trials
Owing to an oversight by the authors, all the figures in the last column of Table 2 (upper section: Number needed to treat; lower section: Number needed to harm) in this article were given without the final di...
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Open AccessFIT for FUNCTION: study protocol for a randomized controlled trial
The current state of evidence suggests that community-based exercise programs are beneficial in improving impairment, function, and health status, and are greatly needed for persons with stroke. However, limit...
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Open AccessEfficacy and safety of stress ulcer prophylaxis in critically ill patients: a network meta-analysis of randomized trials
Stress ulcer prophylaxis (SUP) is commonly prescribed in the intensive care unit. However, data from systematic reviews and conventional meta-analyses are limited by imprecision and restricted to direct compar...
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N-of-1 Randomized Trials of Ultra-Micronized Palmitoylethanolamide in Older Patients with Chronic Pain
Ultra-micronized palmitoylethanolamide (um-PEA) represents an attractive option for chronic pain control in complex older patients at higher risk of adverse effects with traditional analgesics.
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Open AccessRequirements of health policy and services journals for authors to disclose financial and non-financial conflicts of interest: a cross-sectional study
The requirements of the health policy and services journals for authors to report their financial and non-financial conflicts of interest (COI) are unclear. The present article aims to assess the requirements ...
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Open AccessEfficacy and safety of proton pump inhibitors for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis of randomized trials
The relative efficacy and safety of proton pump inhibitors (PPIs) compared to histamine-2-receptor antagonists (H2RAs) should guide their use in reducing bleeding risk in the critically ill.
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Open AccessBehavioral activation group therapy for reducing depressive symptoms and improving quality of life: a feasibility study
Depression is associated with a loss of productivity and noticeable personal, social, and economic decline; it affects more than 350 million people worldwide. Behavioral activation (BA), derived from cognitive...
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Article
Open AccessInternational law’s effects on health and its social determinants: protocol for a systematic review, meta-analysis, and meta-regression analysis
In recent years, there have been numerous calls for global institutions to develop and enforce new international laws. International laws are, however, often blunt instruments with many uncertain benefits, cos...