5,172 Result(s)
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Article
Fu** Qian
Life Sciences
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Article
Cold tolerance SNPs and candidate gene mining in the soybean germination stage based on genome-wide association analysis
Three QTLs associated with low-temperature tolerance were identified by genome-wide association analysis, and 15 candidate genes were identified by haplotype analysis and gene expression analyses.
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Open AccessNano-Se exhibits limited protective effect against heat stress induced poor breast muscle meat quality of broilers compared with other selenium sources
At present, heat stress (HS) has become a key factor that impairs broiler breeding industry, which causes growth restriction and poor meat quality of broilers. Selenium (Se) is an excellent antioxidant and pla...
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Open AccessTaqTth-hpRNA: a novel compact RNA-targeting tool for specific silencing of pathogenic mRNA
Pathogenic allele silencing is a promising treatment for genetic hereditary diseases. Here, we develop an RNA-cleaving tool, TaqTth-hpRNA, consisting of a small, chimeric TaqTth, and a hairpin RNA guiding prob...
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Open AccessNew advances in drug development for metabolic dysfunction-associated diseases and alcohol-associated liver disease
Metabolic disorders are currently threatening public health worldwide. Discovering new targets and develo** promising drugs will reduce the global metabolic-related disease burden. Metabolic disorders primar...
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Open AccessGenome-wide identification and analysis of monocot-specific chimeric jacalins (MCJ) genes in Maize (Zea mays L.)
The monocot chimeric jacalins (MCJ) proteins, which contain a jacalin-related lectin (JRL) domain and a dirigent domain (DIR), are specific to Poaceae. MCJ gene family is reported to play an important role in ...
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Open AccessDeep migration learning-based recognition of diseases and insect pests in Yunnan tea under complex environments
The occurrence, development, and outbreak of tea diseases and pests pose a significant challenge to the quality and yield of tea, necessitating prompt identification and control measures. Given the vast array ...
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Open AccessRetraction Note: CircHAS2 promotes the proliferation, migration, and invasion of gastric cancer cells by regulating PPM1E mediated by hsa-miR-944
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PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels
PAQR4 is an orphan receptor in the PAQR family with an unknown function in metabolism. Here, we identify a critical role of PAQR4 in maintaining adipose tissue function and whole-body metabolic health. We demo...
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Identification of potential PIM-2 inhibitors via ligand-based generative models, molecular docking and molecular dynamics simulations
Proviral Integrations of Moloney-2 (PIM-2) kinase is a promising target for various cancers and other diseases, and its inhibitors hold potential for treating related diseases. However, there is currently no c...
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Open AccessMacrophage migration inhibitory factor (MIF) suppresses mitophagy through disturbing the protein interaction of PINK1-Parkin in sepsis-associated acute kidney injury
Damage to renal tubular epithelial cells (RTECs) signaled the onset and progression of sepsis-associated acute kidney injury (SA-AKI). Recent research on mitochondria has revealed that mitophagy plays a crucia...
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Erratum to: Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival
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A rapid and efficient Agrobacterium-mediated transient transformation system in grape berries
Transient transformation is extremely useful for rapid in vivo assessment of gene function, especially for fruit-related genes. Grape berry, while an important fruit crop, is recalcitrant to transient transfor...
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Ethylene may be the Key Factor Leading to the Homologous Transformation of Stamens into Pistils in Three-Pistil Wheat
Previous studies have shown that ethylene levels in flower buds are key to sex determination in plants. However, the roles of ethylene in wheat flower development are poorly understood. In this study, pistillo...
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Plastome structure, phylogeny and evolution of plastid genes in Reevesia (Helicteroideae, Malvaceae)
Reevesia is an eastern Asian-eastern North American disjunction genus in the family Malvaceae s.l. and comprises approximately 25 species. The relationships within the genus are not well understood. Here, 15 plas...
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Engineering biomimetic nanosystem targeting multiple tumor radioresistance hallmarks for enhanced radiotherapy
Tumor cells establish a robust self-defense system characterized by hypoxia, antioxidant overexpression, DNA damage repair, and so forth to resist radiotherapy. Targeting one of these features is insufficient ...
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Conserved genetic background but geographically differentiated DNA methylation patterns in invasive alligator weed (Alternanthera philoxeroides) populations of China and Japan
Alligator weed (Alternanthera philoxeroides) is a highly invasive species that has successfully established in numerous tropical and subtropical regions worldwide. Previous literature suggests that alligator weed...
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Bacteriophage protein Dap1 regulates evasion of antiphage immunity and Pseudomonas aeruginosa virulence impacting phage therapy in mice
Bacteriophages have evolved diverse strategies to overcome host defence mechanisms and to redirect host metabolism to ensure successful propagation. Here we identify a phage protein named Dap1 from Pseudomonas ae...
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The Association Between the Levels of Oxidative Stress Indicators (MDA, SOD, and GSH) in Seminal Plasma and the Risk of Idiopathic Oligo-asthenotera-tozoospermia: Does Cu or Se Level Alter the Association?
Epidemiological studies on the associations between the levels of oxidative stress (OS) indicators (MDA, SOD, and GSH) in seminal plasma and the risk of idiopathic oligo-asthenotera-tozoospermia (OAT) are stil...
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Meta-analysis reveals the effects of microbial inoculants on the biomass and diversity of soil microbial communities
Microbial inoculation involves transplanting microorganisms from their natural habitat to new plants or soils to improve plant performance, and it is being increasingly used in agriculture and ecological resto...
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Non-B-form DNA is associated with centromere stability in newly-formed polyploid wheat
Non-B-form DNA differs from the classic B-DNA double helix structure and plays a crucial regulatory role in replication and transcription. However, the role of non-B-form DNA in centromeres, especially in poly...
