55 Result(s)
within
English
Feng Jiang**
Article
Life Sciences
-
Article
Open AccessAscorbic acid can promote the generation and expansion of neuroepithelial-like stem cells derived from hiPS/ES cells under chemically defined conditions through promoting collagen synthesis
Spinal cord injury (SCI) is a neurological, medically incurable disorder. Human pluripotent stem cells (hPSCs) have the potential to generate neural stem/progenitor cells (NS/PCs), which hold promise in the tr...
-
Article
Open AccessCircCNTNAP3-TP53-positive feedback loop suppresses malignant progression of esophageal squamous cell carcinoma
Mutation or downregulation of p53 (encoded by TP53) accelerates tumorigenesis and malignant progression in esophageal squamous cell carcinoma (ESCC). However, it is still unknown whether circular RNAs (circRNA...
-
Article
The AKR1B1 inhibitor epalrestat suppresses the progression of cervical cancer
Cervical cancer is the leading cause of cancer-related death among women worldwide. Identifying an effective treatment with fewer side effects is imperative, because all of the current treatments have unique d...
-
Article
Characterization of genome-wide microRNAs and their roles in development and biotic stress in pear
Using a genome-wide analysis of miRNAs in ‘Yali’ pear (Pyrus bretschneideri) via the next-generation high-throughput sequencing of small RNAs with a bioinformatics analysis, we found that pbr-miR156, pbr-miR164, ...
-
Article
Correlation between S100A11 and the TGF-β1/SMAD4 pathway and its effects on the proliferation and apoptosis of pancreatic cancer cell line PANC-1
S100A11 as a S100 protein family member has been documented to play dual-direction regulation over cancer cell proliferation. We explored the role of S100A11 in the proliferation and apoptosis of pancreatic ca...
-
Article
β2-AR regulates the expression of AKR1B1 in human pancreatic cancer cells and promotes their proliferation via the ERK1/2 pathway
Psychological stress has been recognized as a well-documented risk factor associated with β2-adrenergic receptor (β2-AR) in the development of pancreatic cancer. Aldo–keto reductase 1 member B1 (AKR1B1) is a p...
-
Article
Association between serum somatostatin levels and glucose-lipid metabolism in the **o ethnic minority and Han Chinese population
We aim to investigate the relationship between serum somatostatin (SST) levels and glucose-lipid metabolism at various stages of glucose tolerance in the **o ethnic minority (n=111) and Han population (n=113) of...
-
Article
Modulatory effects of bufalin, an active ingredient from toad venom on voltage-gated sodium channels
Chan-su (toad venom) has been used as an analgesic agent in China from ancient to modern times. Bufalin, a non-peptide toxin extracted from toad venom, is considered as one of the analgesic components. The mol...
-
Article
Functional traits can improve our understanding of niche- and dispersal-based processes
Ecologists often determine the relative importance of niche- and dispersal-based processes via variation partitioning based on species composition. Functional traits and their proxies of phylogeny are expected...
-
Article
Retraction Note: DNA-guided genome editing using the Natronobacterium gregoryi Argonaute
Nat. Biotechnol. 34, 768–773 (2016); published online 2 May 2016; addendum published after print 28 November 2016; retracted 26 July 2017; 10.1038/nbt.3547 We are retracting our study because of the continued ...
-
Article
Addendum: Editorial Expression of Concern: DNA-guided genome editing using the Natronobacterium gregoryi Argonaute
-
Article
Open AccessDissecting the biological relationship between TCGA miRNA and mRNA sequencing data using MMiRNA-Viewer
MicroRNAs (miRNA) are short nucleotides that interact with their target genes through 3′ untranslated regions (UTRs). The Cancer Genome Atlas (TCGA) harbors an increasing amount of cancer genome data for both ...
-
Article
Open AccessRead-Split-Run: an improved bioinformatics pipeline for identification of genome-wide non-canonical spliced regions using RNA-Seq data
Most existing tools for detecting next-generation sequencing-based splicing events focus on generic splicing events. Consequently, special types of non-canonical splicing events of short mRNA regions (IRE1α ta...
-
Article
DNA-guided genome editing using the Natronobacterium gregoryi Argonaute
Genome editing guided by a short single-stranded DNA is achieved with a nuclease from an archaebacterium.
-
Article
Open AccessStudies of genetic variability of the hepatocyte nuclear factor-1α gene in an Indian maturity-onset diabetes of the young family
Maturity-onset diabetes of the young (MODY), one of the specific types of diabetes mellitus, is a monogenetic disorder characterized by an autosomal dominant (AD) inheritance and β-cell dysfunction. To study a...
-
Article
Open AccessIdentification and functional analysis of olfactory receptor family reveal unusual characteristics of the olfactory system in the migratory locust
Locusts represent the excellent model of insect olfaction because the animals are equipped with an unusual olfactory system and display remarkable density-dependent olfactory plasticity. However, information r...
-
Article
Open AccessScorpion toxin BmK I directly activates Nav1.8 in primary sensory neurons to induce neuronal hyperexcitability in rats
Voltage-gated sodium channels (VGSCs) in primary sensory neurons play a key role in transmitting pain signals to the central nervous system. BmK I, a site-3 sodium channel-specific toxin from scorpion Buthus mart...
-
Article
Ameliorating Effects of Combined Curcumin and Desferrioxamine on 6-OHDA-Induced Rat Mode of Parkinson’s Disease
The catecholaminergic neurotoxin 6-hydroxydopamine has been widely used to mimic the lesions in dopaminergic neurons to develop Parkinson’s disease. The present study was aimed to evaluate the combined treatm...
-
Article
Isolation and characterization of microsatellite loci from Gasterophilus pecorum (Diptera: Gasterophilidae)
Gasterophilus pecorum (Diptera: Gasterophilidae) is the most damaging parasites in Przewalaski’s horses that were re-wilded in Kalamaili, **njiang, China. In this study, 18 polymorphic microsatel...
-
Article
Analysis of genomic characters reveals that four distinct gene clusters are correlated with different functions in Burkholderia cenocepacia AU 1054
Possessing three circular chromosomes is a distinct genomic characteristic of Burkholderia cenocepacia AU 1054, a clinically important pathogen in cystic fibrosis. In this study, base composition, codon usage and...
