499 Result(s)

Article

LncRNA MIR31HG fosters stemness malignant features of non-small cell lung cancer via H3K4me1- and H3K27Ace-mediated GLI2 expression

Non-coding RNAs are responsible for oncogenesis and the development of stemness features, including multidrug resistance and metastasis, in various cancers. Expression of lncRNA MIR31HG in lung cancer tissues ...

Weiwei Chen, Fei Wang, **nyuan Yu, **g**g Qi, Hongliang Dong, Bingjie Cui… in Oncogene (2024)

Article

Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia: a prospective, single arm, phase I trial

Patients with refractory immune thrombocytopenia (ITP) frequently encounter substantial bleeding risks and demonstrate limited responsiveness to existing therapies. Umbilical cord-derived mesenchymal stem cell...

Yunfei Chen, Yanmei Xu, Ying Chi, Ting Sun… in Signal Transduction and Targeted Therapy (2024)

Article

Oral arsenic plus imatinib versus imatinib solely for newly diagnosed chronic myeloid leukemia: a randomized phase 3 trial with 5-year outcomes

The synergistic effects of combining arsenic compounds with imatinib against chronic myeloid leukemia (CML) have been established using in vitro data. We conducted a clinical trial to compare the efficacy of t...

Jie Tian, Yong-** Song, Gao-Chong Zhang… in Journal of Cancer Research and Clinical On… (2024)

Article

XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...

Qiu-Zhong Pan, **g-**g Zhao, Liang Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Macrocyclic peptides: up-and-coming weapons to combat antimicrobial resistance

Wen-**g Wang, **ang-Min Dong, Guo-Bo Li in Signal Transduction and Targeted Therapy (2024)

Article

Development of a Serum-Based MicroRNA Signature for Early Detection of Pancreatic Cancer: A Multicenter Cohort Study

A grim prognosis of pancreatic cancer (PCa) was attributed to the difficulty in early diagnosis of the disease.

**g Huang, Ge Gao, Yang Ge, Jianzhou Liu, Hongtu Cui… in Digestive Diseases and Sciences (2024)

Article

Lipid droplets-related Perilipin-3: potential immune checkpoint and oncogene in oral squamous cell carcinoma

Lipid droplets (LDs) as major lipid storage organelles are recently reported to be innate immune hubs. Perilipin-3 (PLIN3) is indispensable for the formation and accumulation of LDs. Since cancer patients show...

Yijia He, Lingyun Liu, Yuexin Dong, **aoxin Zhang… in Cancer Immunology, Immunotherapy (2024)

Article

Correction: c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses

Xu-Yan Wang, Yuan Wei, Bo Hu, Yuan Liao… in Signal Transduction and Targeted Therapy (2024)

Article

Effect of early peri-operative arterial lactate concentration level ratios on post-hepatectomy liver failure

Post-hepatectomy liver failure (PHLF) is a serious complication after hepatectomy and a major cause of death. The current criteria for PHLF diagnosis (ISGLS consensus) require laboratory data of elevated INR l...

Dong-Dong Wang, Meng-Meng Dong, Ya-Ming **e, Fei-Qi Xu, Tian-Wei Fu… in Discover Oncology (2024)

Article

A CT-based radiomics nomogram involving the cystic fluid area for differentiating appendiceal mucinous neoplasms from appendicitis with intraluminal fluid

To develop and validate a radiomics nomogram based on computed tomography (CT) to distinguish appendiceal mucinous neoplasms (AMNs) from appendicitis with intraluminal fluid (AWIF).

**nbin Wang, Na Feng, Yonggang Qiu, Hao Dong… in Journal of Cancer Research and Clinical On… (2024)

Article

Alpha5 nicotine acetylcholine receptor subunit promotes intrahepatic cholangiocarcinoma metastasis

Neurotransmitter-initiated signaling pathway were reported to play an important role in regulating the malignant phenotype of tumor cells. Cancer cells could exhibit a “neural addiction” property and build up ...

Yan Fu, Keyu Shen, Hao Wang, Shun Wang… in Signal Transduction and Targeted Therapy (2024)

Article

Tertiary lymphoid structures predict survival and response to neoadjuvant therapy in locally advanced rectal cancer

Tertiary lymphoid structure (TLS) contributes to the anti-tumor immune response, and predicts the prognosis of colorectal cancer patients. However, the potential impact of TLS in sha** the immune status of r...

Qianyu Wang, Wentao Zhong, **aofei Shen, Zechen Hao, Meng Wan… in npj Precision Oncology (2024)

Article

Study on the effect and mechanism of Zhenzhu Tongluo pills in treating diabetic peripheral neuropathy injury

As a traditional Mongolian medicine, Zhenzhu Tongluo pills has played a good neuroprotective function in clinic. However, the key mechanisms by which it works are poorly studied.

Pengfei Dong, Lin Zhou, **aohui Wang, Lian** Xue… in European Journal of Medical Research (2024)

Article

Metabolic memory: mechanisms and diseases

Metabolic diseases and their complications impose health and economic burdens worldwide. Evidence from past experimental studies and clinical trials suggests our body may have the ability to remember the past ...

Hao Dong, Yuezhang Sun, Lulingxiao Nie… in Signal Transduction and Targeted Therapy (2024)

Article

Cirrhotic-extracellular matrix attenuates aPD-1 treatment response by initiating immunosuppressive neutrophil extracellular traps formation in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is closely associatedwith chronic liver diseases, particularly liver cirrhosis, which has an altered extracellular matrix (ECM) composition. The influence and its mechanism of th...

**ao-Tian Shen, Sun-Zhe **e, **n Zheng, Tian-Tian Zou… in Experimental Hematology & Oncology (2024)

Article

TEP RNA: a new frontier for early diagnosis of NSCLC

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer (LC), which is the leading cause of tumor mortality. In recent years, compared with tissue biopsy, which is the diagnostic gold standar...

Yuan Wang, Ai** Dong, Minhan **… in Journal of Cancer Research and Clinical On… (2024)

Article

The role of dynamic, static, and delayed total-body PET imaging in the detection and differential diagnosis of oncological lesions

Commercialized total-body PET scanners can provide high-quality images due to its ultra-high sensitivity. We compared the dynamic, regular static, and delayed 18F-fluorodeoxyglucose (FDG) scans to detect lesio...

Ya** Wu, Fangfang Fu, Nan Meng, Zhenguo Wang, **aochen Li, Yan Bai… in Cancer Imaging (2024)

Article

Regulated secretion of mutant p53 negatively affects T lymphocytes in the tumor microenvironment

Several studies have demonstrated the role of the oncogenic mutant p53 in promoting tumor progression; however, there is limited information on the effects of secreted oncogenic mutant p53 on the tumor microen...

**ang Dong, Chunlu Li, Chengsi Deng, **gwei Liu, Danni Li, Tingting Zhou… in Oncogene (2024)