52 Result(s)

Article

Correction to: A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling

An amendment to this paper has been published and can be accessed via the original article.

**ao Zheng, Lujun Chen, You Zhou, Qi Wang, Zhuojun Zheng, Bin Xu… in Molecular Cancer (2021)

Article

Novel therapeutic evaluation biomarkers of lipid metabolism targets in uncomplicated pulmonary tuberculosis patients

Currently, the management of pulmonary tuberculosis (TB) lacks potent medications and accurate efficacy evaluation biomarkers. In view of the fact that the host lipids are the important energy source of Mycobacte...

Jia-** Chen, Yu-Shuai Han, Shan-Qiang Zhang… in Signal Transduction and Targeted Therapy (2021)

Article

Targeting nuclear acid-mediated immunity in cancer immune checkpoint inhibitor therapies

Cancer immunotherapy especially immune checkpoint inhibition has achieved unprecedented successes in cancer treatment. However, there are many patients who failed to benefit from these therapies, highlighting ...

Miaoqin Chen, Shiman Hu, Yiling Li… in Signal Transduction and Targeted Therapy (2020)

Article

Randomized, multicenter, open-label trial of autologous cytokine-induced killer cell immunotherapy plus chemotherapy for squamous non-small-cell lung cancer: NCT01631357

Liang Liu, Quanli Gao, **gting Jiang… in Signal Transduction and Targeted Therapy (2020)

Article

Circulating tumor cells in cancer patients: developments and clinical applications for immunotherapy

Cancer metastasis is the leading cause of cancer-related death. Circulating tumor cells (CTCs) are shed into the bloodstream from either primary or metastatic tumors during an intermediate stage of metastasis....

**aoming Zhong, Hangtian Zhang, Ying Zhu, Yuqing Liang, Zhuolin Yuan… in Molecular Cancer (2020)

Article

High CTHRC1 expression may be closely associated with angiogenesis and indicates poor prognosis in lung adenocarcinoma patients

This study aimed to investigate the prognostic value of the potential biomarker collagen triple helix repeat containing 1 (CTHRC1) in lung adenocarcinoma (LUAD) patients.

Yangshan Chen, Yu Sun, Yongmei Cui, Yiyan Lei, Neng Jiang… in Cancer Cell International (2019)

Article

EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer

Tyrosine kinase inhibitors for epidermal growth factor receptor (EGFR TKIs) greatly improved clinical outcomes of patients with non-small cell lung cancer (NSCLC). Unfortunately, primary and acquired resistanc...

Lixian Yang, Shilong Ying, Shiman Hu… in Signal Transduction and Targeted Therapy (2019)

Article

A germline mutation in Rab43 gene identified from a cancer family predisposes to a hereditary liver-colon cancer syndrome

Hereditary cancer syndromes have inherited germline mutations which predispose to benign and malignant tumors. Understanding of the molecular causes in hereditary cancer syndromes has advanced cancer treatment...

Yanting Jiang, Yue Sun, Jiandong Hu, Nan Yu, Hui Liu, Jiankun Fan… in BMC Cancer (2019)

Article

Over-expression of Nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients

Nectin-4, also known as PVRL4 (poliovirus-receptor-like 4), is specifically expressed in the embryo and placenta. Recent studies have reported that the Nectin-4 is over-expressed in multiple human cancers, and...

Haifeng Deng, Hongbing Shi, Lujun Chen, You Zhou… in Cancer Cell International (2019)

Article

Overexpression of HHLA2 in human clear cell renal cell carcinoma is significantly associated with poor survival of the patients

It is well known that human clear cell renal cell carcinoma (ccRCC) is a highly immunogenic and chemo-resistant tumor. Recently, emerging data suggest that the immune checkpoint blockade therapy is an importan...

Lujun Chen, Dawei Zhu, Jun Feng, You Zhou, Qi Wang… in Cancer Cell International (2019)

Article

A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling

It has been well established that circular RNAs (circRNAs) play an important regulatory role during tumor progression. Recent studies have indicated that even though circRNAs generally regulate gene expression...

**ao Zheng, Lujun Chen, You Zhou, Qi Wang, Zhuojun Zheng, Bin Xu… in Molecular Cancer (2019)

Article

MiR-1180 from bone marrow MSCs promotes cell proliferation and glycolysis in ovarian cancer cells via SFRP1/Wnt pathway

The ovarian cancer microenvironment is responsible for cancer cell growth and disease relapse. Bone marrow mesenchymal stem cells (BM-MSCs) play important roles in ovarian cancer, however, the mechanism of BM-...

**ghui Hu, Wei Zhao, Yujie Huang, Zhe Wang, Tingting Jiang… in Cancer Cell International (2019)

Article

Aberrant fatty acid profile and FFAR4 signaling confer endocrine resistance in breast cancer

Evidence suggests that fatty acid receptor FFAR4 plays a tumor-promoting role in adipose tissue-adjacent malignancies, but its clinical relevance remains unexplored. Here, we investigated the clinical signific...

**ao Chu, Qi Zhou, Yingchun Xu… in Journal of Experimental & Clinical Cancer … (2019)

Article

Circulating tumor cells with karyoty** as a novel biomarker for diagnosis and treatment of nasopharyngeal carcinoma

Circulating tumor cells (CTCs) have been considered great clinical significance in various cancers. However, it remains unknown that how is the role of CTCs in patients with nasopharyngeal carcinoma (NPC). We ...

**g Zhang, Huashan Shi, Tingting Jiang, Zhe Liu, Peter P. Lin, Nianyong Chen in BMC Cancer (2018)

Article

Decreased RIG-I expression is associated with poor prognosis and promotes cell invasion in human gastric cancer

Retinoic acid-induced protein I (RIG-I), known as a cytoplastic pattern recognition receptor, can recognize exogenous viral RNAs, and then initiate immune response. Recently, numerous studies also showed that ...

Lujun Chen, Jun Feng, Shaoxian Wu, Bin Xu, You Zhou… in Cancer Cell International (2018)

Article

Correction to: Expression of B7-H6 expression in human hepatocellular carcinoma and its clinical significance

Following publication of the original article [1], the authors reported a ty** mistake in the title. In this Correction the incorrect and correct titles are shown.

Lujun Chen, Jun Feng, Bin Xu, You Zhou, … in Cancer Cell International (2018)

Article

Expression of B7-H6 expression in human hepatocellular carcinoma and its clinical significance

Recent studies have suggested that B7-H6, a new member of the B7 family of ligands, not only is a crucial regulator of NK cell-mediated immune responses but also has important clinical implications due to its ...

Lujun Chen, Jun Feng, Bin Xu, You Zhou, … in Cancer Cell International (2018)

Article

Function and clinical significance of circRNAs in solid tumors

Circular RNA (circRNA) is a new type of endogenous non-coding RNAs (ncRNAs). circRNA regulates gene expression in many biological processes, and it also participates in the initiation and development of variou...

Yiting Geng, **gting Jiang, Chang** Wu in Journal of Hematology & Oncology (2018)