615 Result(s)
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Open AccessPopulation-based BRCA germline mutation screening in the Han Chinese identifies individuals at risk of BRCA mutation-related cancer: experience from a clinical diagnostic center from greater Shanghai area
Deleterious BRCA1/2 (BRCA) mutation raises the risk for BRCA mutation-related malignancies, including breast, ovarian, prostate, and pancreatic cancer. Germline variation of BRCA exhibits substantial ethnical div...
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Comparison of the predictive values of MRI-based vertebral bone quality scores for the determination of osteoporosis in different diseases
The study aimed to examine the consistency of vertebral bone quality (VBQ) scores for assessing osteoporosis across different etiologies and explore the predictive value of various VBQ scores for fragility ver...
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Tricarboxylic acid cycle metabolites: new players in macrophage
Metabolic remodeling is a key feature of macrophage activation and polarization. Recent studies have demonstrated the role of tricarboxylic acid (TCA) cycle metabolites in the innate immune system. In the curr...
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AGV indoor localization: a high fidelity positioning and map building solution based on drawstring displacement sensors
The rapid evolution of artificial intelligence (AI) and robotics technologies are bringing drastic changes to society and industry in these recent years. The impressive progress in facilitating smart manufactu...
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Open AccessA prospective phase II clinical trial of total neoadjuvant therapy for locally advanced gastric cancer and gastroesophageal junction adenocarcinoma
To investigate the safety and efficacy of the neoadjuvant chemoradiotherapy (NCRT) followed by neoadjuvant consolidation chemotherapy (NCCT) and surgery for locally advanced gastric cancer (GC) or gastroesopha...
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Open AccessTailoring d-band center of high-valent metal-oxo species for pollutant removal via complete polymerization
Polymerization-driven removal of pollutants in advanced oxidation processes (AOPs) offers a sustainable way for the simultaneous achievement of contamination abatement and resource recovery, supporting a low-c...
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Open AccessMulti-modal molecular determinants of clinically relevant osteoporosis subtypes
Due to a rapidly aging global population, osteoporosis and the associated risk of bone fractures have become a wide-spread public health problem. However, osteoporosis is very heterogeneous, and the existing s...
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Investigating the Loess Plateau’s coevolution of precipitation and natural vegetation cover
The Chinese government’s program of reverting agriculture to forests and grasslands has largely been responsible for the phenomenon of the Loess Plateau becoming green, which has attracted the attention of the...
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Open AccessAssociation of dietary live microbe intake with various cognitive domains in US adults aged 60 years or older
The purpose of this study was to explore whether dietary live microbe intake is associated with various cognitive domains using data from the National Health and Nutrition Examination Survey (NHANES) from 2011...
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Comparing robotic and open surgical techniques in gallbladder cancer management: a detailed systematic review and meta-analysis
This meta-analysis aims to evaluate the safety and oncological outcomes of robotic surgery compared to open surgery in treating gallbladder cancer (GBC). In October 2023, we performed a literature search acros...
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Open AccessGenome-wide identification of GA2ox genes family and analysis of PbrGA2ox1-mediated enhanced chlorophyll accumulation by promoting chloroplast development in pear
Chlorophyll (Chl) is an agronomic trait associated with photosynthesis and yield. Gibberellin 2-oxidases (GA2oxs) have previously been shown to be involved in Chl accumulation. However, whether and how the Pbr...
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Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated TLE1 m6A modification
N6-methyladenosine (m6A) modification is a prevalent RNA epigenetic modification, which plays a crucial role in tumor progression including metastasis. Isothiocyanates (ITCs) are natural compounds and inhibit the...
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ZIF-8-functionalized polymer electrolyte with enhanced performance for high-temperature solid-state lithium metal batteries
Solid polymer electrolytes (SPEs) with high ionic conductivity are desirable for solid-state lithium metal batteries (SSLMBs) to achieve enhanced safety and energy density. Incorporating nanofillers into a pol...
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Research on the knee region of cosmic ray by using a novel type of electron–neutron detector array
By accurately measuring composition and energy spectrum of cosmic ray, the origin problem of so called “knee” region (energy >one PeV) can be solved. However, up to the present, the results of the spectrum in ...
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Open AccessAddendum: Cellular differentiation into hyphae and spores in halophilic archaea
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Structures and diversities of bacterial communities in oil-contaminated soil at shale gas well site assessed by high-throughput sequencing
Currently, there is limited understanding of the structures and variabilities of bacterial communities in oil-contaminated soil within shale gas development. The Changning shale gas well site in Sichuan provin...
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Open AccessMulti-omics and Multi-VOIs to predict esophageal fistula in esophageal cancer patients treated with radiotherapy
This study aimed to develop a prediction model for esophageal fistula (EF) in esophageal cancer (EC) patients treated with intensity-modulated radiation therapy (IMRT), by integrating multi-omics features from...
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Human microbiota from drug-naive patients with obsessive-compulsive disorder drives behavioral symptoms and neuroinflammation via succinic acid in mice
Emerging evidence suggests that the gut microbiota is closely related to psychiatric disorders. However, little is known about the role of the gut microbiota in the development of obsessive-compulsive disorder...
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Open AccessA compact multi-pixel superconducting nanowire single-photon detector array supporting gigabit space-to-ground communications
Classical and quantum space-to-ground communications necessitate highly sensitive receivers capable of extracting information from modulated photons to extend the communication distance from near-earth orbits ...
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Open AccessIn vivo assembly enhanced binding effect augments tumor specific ferroptosis therapy
Emerging evidence indicates that the activation of ferroptosis by glutathione peroxidase 4 (GPX4) inhibitors may be a prominent therapeutic strategy for tumor suppression. However, the wide application of GPX4...