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**fa Guan
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Life Sciences
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Article
Open AccessHippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity
Natural killer (NK) cells play a crucial role in immune response against viral infections and tumors. However, further investigation is needed to better understand the key molecules responsible for determining...
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A climate sensitive nonlinear mixed-effects height to crown base model: a study focuses on Phyllostachys pubescens
A climate-sensitive height to crown base (HCB) model developed by combining a nonlinear mixed-effects model and dummy variable approach led to higher prediction accuracy of HCB than those without climatic vari...
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Effect of wogonin, an active ingredient of Scutellariae Radix, on fish infected with Aeromonas hydrophila
Exposure to pathogens induces hyperactivate inflammatory immune responses, oxidative stress and even death in fish. Therefore, suppressing excessive inflammatory responses is a means of treating fish diseases....
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Open AccessEnvironment influences the genetic structure and genetic differentiation of Sassafras tzumu (Lauraceae)
Sassafras tzumu, an elegant deciduous arboreal species, belongs to the esteemed genus Sassafras within the distinguished family Lauraceae. With its immense commercial value, escalating market demands and unforese...
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Open AccessThe mRNA surveillance factor Pelo restricts rice virus propagation in insect vectors and host plants
Many devastating plant viruses are transmitted by insect vectors among plant hosts in a persistent-propagative manner. Pelota (Pelo) is an evolutionarily conserved protein involved in the mRNA surveillance sys...
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Efficient production of polyhydroxybutyrate using lignocellulosic biomass derived from oil palm trunks by the inhibitor-tolerant strain Burkholderia ambifaria E5-3
Lignocellulosic biomass is a valuable, renewable substrate for the synthesis of polyhydroxybutyrate (PHB), an ecofriendly biopolymer. In this study, bacterial strain E5-3 was isolated from soil in Japan; it wa...
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Open AccessCrowd-sourced benchmarking of single-sample tumor subclonal reconstruction
Subclonal reconstruction algorithms use bulk DNA sequencing data to quantify parameters of tumor evolution, allowing an assessment of how cancers initiate, progress and respond to selective pressures. We launc...
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Open AccessGenome-wide association analysis and transgenic characterization for amylose content regulating gene in tuber of Dioscorea zingiberensis
Amylose, a prebiotic found in yams is known to be beneficial for the gut microflora and is particularly advantageous for diabetic patients’ diet. However, the genetic machinery underlying amylose production re...
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Open AccessIdentification and analysis of short-term and long-term salt-associated lncRNAs in the leaf of Avicennia marina
As a highly salt-resistant mangrove, Avicennia marina can thrive in the hypersaline water. The leaves of Avicennia marina play a crucial role in salinity stress adaptability by secreting salt. Although the functi...
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Open AccessBacteria colonization and gene expression related to immune function in colon mucosa is associated with growth in neonatal calves regardless of live yeast supplementation
As Holstein calves are susceptible to gastrointestinal disorders during the first week of life, understanding how intestinal immune function develops in neonatal calves is important to promote better intestina...
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Author Correction: Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos
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Author Correction: Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing
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Open AccessGenome editing toward biofortified soybean with minimal trade-off between low phytic acid and yield
Phytic acid (PA) in grain seeds reduces the bioavailability of nutrient elements in monogastric animals, and an important objective for crop seed biofortification is to decrease the seed PA content. Here, we e...
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Unveiling Characteristics of Woody Biomass Torrefaction Through Kinetic Modeling
The direct use of biomass for energy generation is usually unfavorable due to its unsatisfied characteristics. Those characteristics could be eliminated by a mild temperature pre-treatment such as torrefaction...
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Open AccessGerm cell-specific gene 2 accelerates cell cycle in epithelial ovarian cancer by inhibiting GSK3α-p27 cascade
Epithelial ovarian cancer (EOC) is one of the most common malignant gynecological tumors with rapid growth potential and poor prognosis, however, the molecular mechanism underlying its outgrowth remained elusi...
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Genome-wide identification of thaumatin-like protein family genes in Panax notoginseng and analysis of their responses to Fusarium solani infection
Panax notoginseng (Burke) F. H. Chen, which is commonly referred as ''Sanqi'', is the most widely used Chinese medicinal herb. Root rot can have deleterious effects on the success of Sanqi cultivation, including ...
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Mammalian IRE1α dynamically and functionally coalesces with stress granules
Upon endoplasmic reticulum (ER) stress, activation of the ER-resident transmembrane protein kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1) initiates a key branch of the unfolded protein response (U...
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Factors contributing to China’s carbon stock change in the harvested wood products trade
Trade in harvested wood products (HWPs) induces carbon stock changes between different countries. Carbon stock change significantly influences a country’s contribution to carbon removals. China is a net import...
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Food web restoration lags behind biological communities: a case study from a floodplain wetland
Conservation and restoration of wetlands have become a global priority as awareness of their importance increases. At present, efforts to restore wetlands have primarily focused on enhancing water quality and ...
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Treatment of Syringomyelia Characterized by Focal Dilatation of the Central Canal Using Mesenchymal Stem Cells and Neural Stem Cells
Syringomyelia is a progressive chronic disease that leads to nerve pain, sensory dissociation, and dyskinesia. Symptoms often do not improve after surgery. Stem cells have been widely explored for the treatmen...
