180 Result(s)

Article

The functional change of the P2X7R containing the Ala³⁴⁸ to Thr polymorphism is associated with the pathogenesis of gout

Our previous study has shown that ATP action on P2X7R could be the second signal to induce the onset of gouty arthritis. However, the functional changes of P2X7R single nucleotide polymorphisms (SNPs) on the e...

Man-Yun Li, Xuan Fang, Yan Ma, **an-Yang Pan, **ao-Juan Dai… in Scientific Reports (2023)

Article

Effect of serum progesterone on human chorionic gonadotropin trigger day / metaphase II oocyte ratio on pregnancy and neonatal outcomes in women undergoing ICSI cycle

The serum progesterone on human chorionic gonadotropin trigger day / metaphase II oocyte (P/MII) ratio might be a more predictable indicator of pregnancy and neonatal outcomes as compare to P/estradiol (E2) or...

Li-Juan Huang, Qi Wan, Tian Li, **ng-Yu Lv, Li-Hong Geng… in BMC Pregnancy and Childbirth (2023)

Article

The spatiotemporal matching pattern of Ezrin/Periaxin involved in myoblast differentiation and fusion and Charcot-Marie-Tooth disease-associated muscle atrophy

Clinically, Charcot-Marie-Tooth disease (CMT)-associated muscle atrophy still lacks effective treatment. Deletion and mutation of L-periaxin can be involved in CMT type 4F (CMT4F) by destroying the myelin shea...

Ruo-nan Zhang, **n Bao, Yun Liu, Yan Wang… in Journal of Translational Medicine (2023)

Article

3′ UTR is critical for viral RNA accumulation of jasmine virus H

Jasmine virus H (JaVH) is a newly reported viral pathogen of jasmine in China and USA. To study the viral gene function and pathogenic mechanism, a full-length infectious clone of JaVH (pXT-JaVH^FJ) was constructe...

Li-Juan Zhu, Chong-Tao Zhang, Ya-Ni Bai, Chao-Yang Jiang… in Phytopathology Research (2023)

Article

A modified renal risk score for Chinese patients with antineutrophil cytoplasmic antibody-associated vasculitis

The renal risk score (RRS) is a useful tool to predict end-stage renal disease (ESRD) in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The current study aimed to validat...

Rui-Xue Wang, **-Wei Wang, Zhi-Ying Li, Su-Fang Chen, **ao-Juan Yu… in BMC Medicine (2023)

Article

Continuous exposure to isoprenaline reduced myotube size by delaying myoblast differentiation and fusion through the NFAT-MEF2C signaling pathway

We aimed to explore whether superfluous sympathetic activity affects myoblast differentiation, fusion, and myofiber types using a continuous single-dose isoprenaline exposure model in vitro and to further conf...

**g Yue, Wei Xu, Li **ang, Shao-juan Chen, **n-yuan Li, Qian Yang… in Scientific Reports (2023)

Article

Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma

The patients with relapsed and refractory diffuse large B-cell lymphoma (DLBCL) have poor prognosis, and a novel and effective therapeutic strategy for these patients is urgently needed. Although ubiquitin-spe...

**-Ya Li, Ji-Chuan Wu, ** Liu, Zi-Juan Li, Yong Wang, Bing-Yi Chen… in Leukemia (2023)

Article

Diversity of Trichoderma species associated with soil in the Zoige alpine wetland of Southwest China

The ecology of soil fungi is poorly understood, and recent comprehensive reports on Trichoderma are unavailable for any region, including the Zoige alpine wetland ecological region in China. One hundred soil samp...

Gui-Ting Tang, Ying Li, You Zhou, Yu-Hang Zhu, **ao-Juan Zheng… in Scientific Reports (2022)

Article

Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia

Aberrant self-renewal of leukemia initiation cells (LICs) drives aggressive acute myeloid leukemia (AML). Here, we report that UHRF1, an epigenetic regulator that recruits DNMT1 to methylate DNA, is highly exp...

Cheng-Long Hu, Bing-Yi Chen, Zijuan Li, Tianbiao Yang, Chun-Hui Xu… in Cell Research (2022)

Article

E2F1-initiated transcription of PRSS22 promotes breast cancer metastasis by cleaving ANXA1 and activating FPR2/ERK signaling pathway

Breast cancer (BC) is the most common malignant tumor in women worldwide. Metastasis is the main cause of BC-related death. The specific mechanism underlying BC metastasis remains obscure. Recently, PRSS22 was...

Lin Song, Hui Li, Ran-Ran Ma, Sen Liu, Guo-Hao Zhang, **ang-Yu Guo… in Cell Death & Disease (2022)

Article

Systematic analysis of expression profiles and prognostic significance for MMDS-related iron–sulfur proteins in renal clear cell carcinoma

Mitochondrial metabolism disorders play an important role in the occurrence and development of tumors, and iron–sulfur protein is an important molecule for maintaining the normal function of mitochondria. Howe...

Ling Yang, Yu-**n Chen, Ying-Ying Li, **ao-Juan Liu, Yong-Mei Jiang… in Scientific Reports (2022)

Article

The purine metabolite inosine monophosphate accelerates myelopoiesis and acute pancreatitis progression

Hyperglycemia-induced myelopoiesis and atherosclerotic progression occur in mice with type I diabetes. However, less is known about the effects of metabolites on myelopoesis in type 2 diabetes. Here, we use fl...

**ao-Min Luo, Sin Man Lam, Yuan Dong, **ao-Juan Ma, Cen Yan… in Communications Biology (2022)

Article

Association between new onset type 1 diabetes and real-world antibiotics and neonicotinoids’ exposure-related gut microbiota perturbation

The real-world exposure levels of non-therapeutic antibiotics and neonicotinoids in type 1 diabetes (T1D) children and their associations as environmental triggers through gut microbiota shifts remained unknow...

Zhen-Ran Xu, **ao-**ao Yuan, Rui-Min Chen, Hai-Yan Wei… in World Journal of Pediatrics (2022)

Article

Metagenomic and metatranscriptomic insights into sulfate-reducing bacteria in a revegetated acidic mine wasteland

The widespread occurrence of sulfate-reducing microorganisms (SRMs) in temporarily oxic/hypoxic aquatic environments indicates an intriguing possibility that SRMs can prevail in constantly oxic/hypoxic terrest...

**-tian Li, Pu Jia, **ao-juan Wang, Shu-ning Ou… in npj Biofilms and Microbiomes (2022)

Article

Comparative genome anatomy reveals evolutionary insights into a unique amphitriploid fish

Triploids are rare in nature because of difficulties in meiotic and gametogenic processes, especially in vertebrates. The Carassius complex of cyprinid teleosts contains sexual tetraploid crucian carp/goldfish (C...

Yang Wang, **-Yin Li, Wen-Jie Xu, Kun Wang, Bin Wu, Meng Xu… in Nature Ecology & Evolution (2022)

Article

Short term outcomes of extremely low birth weight infants from a multicenter cohort study in Guangdong of China

With the increase in extremely low birth weight (ELBW) infants, their outcome attracted worldwide attention. However, in China, the related studies are rare. The hospitalized records of ELBW infants discharged...

Chun-Hong Jia, Zhou-Shan Feng, **ao-Jun Lin, Qi-Liang Cui… in Scientific Reports (2022)

Article

Correction to: Matrine Treatment Blocks NogoA-Induced Neural Inhibitory Signaling Pathway in Ongoing Experimental Autoimmune Encephalomyelitis

Quan-Cheng Kan, Hui-Jun Zhang, Yuan Zhang, **ng Li, Yu-Ming Xu… in Molecular Neurobiology (2022)

Article

Implementation of sodium alginate-Fe₃O₄ to localize undiagnosed small pulmonary nodules for surgical management in a preclinical rabbit model

Many methods are used to locate preoperative small pulmonary nodules. However, deficiencies of complications and success rates exist. We introduce a novel magnetic gel for small pulmonary nodules localization ...

Zhi-xuan Zhang, Lu Lv, Ai-hua Shi, Yun-hao Li, Tian-ren Wang… in Scientific Reports (2022)

Article

Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder

The nucleus accumbens (NAc) is considered a hub of reward processing and a growing body of evidence has suggested its crucial role in the pathophysiology of major depressive disorder (MDD). However, inconsiste...

Yu-Dan Ding, **ao Chen, Zuo-Bing Chen, Le Li, Xue-Ying Li… in Translational Psychiatry (2022)

Article

Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress

Many studies about depression have focused on the dysfunctional synaptic signaling in the hippocampus that drives the pathophysiology of depression. Radix Bupleuri has been used in China for over 2000 years to re...

Chen-Yue Liu, Jian-Bei Chen, Yue-Yun Liu, Xue-Ming Zhou, Man Zhang… in Chinese Medicine (2022)