67 Result(s)

Article

IFITM3 inhibits virus-triggered induction of type I interferon by mediating autophagosome-dependent degradation of IRF3

Interferon-induced transmembrane protein 3 (IFITM3) is a restriction factor that can be induced by viral infection and interferons (IFNs). It inhibits the entry and replication of many viruses, which are indep...

Li-Qun Jiang, Tian **a, Yun-Hong Hu, Ming-Shun Sun… in Cellular & Molecular Immunology (2018)

Article

Degranulation of mast cells induced by gastric cancer-derived adrenomedullin prompts gastric cancer progression

Mast cells are prominent components of solid tumors and exhibit distinct phenotypes in different tumor microenvironments. However, their precise mechanism of communication in gastric cancer remains largely unc...

Yi-pin Lv, Liu-sheng Peng, Qi-hong Wang, Na Chen, Yong-sheng Teng… in Cell Death & Disease (2018)

Article

PLZF play as an indirect facilitator of thymic retention for the innate-like T-cells to aquire innate-like functions

**n Cao, **ao-xia Ma, Yu-jia Xue, Yan Zeng, **an-yu Zhang, Ying Lu… in Cell Death & Disease (2018)

Article

Loss of oocyte Rps26 in mice arrests oocyte growth and causes premature ovarian failure

Global transcriptional activity increases as oocytes grow and is silenced in fully grown oocytes. Thus, the chromatin configuration varies during oocyte growth, but the molecular mechanisms regulating these ch...

**ao-Man Liu, Ming-Qi Yan, Shu-Yan Ji, Qian-Qian Sha, Tao Huang… in Cell Death & Disease (2018)

Article

Sphingosine 1 phosphate receptor-1 (S1P1) promotes tumor-associated regulatory T cell expansion: leading to poor survival in bladder cancer

Regulatory T cells (Tregs) represent an important contributor to cancer immune escape, but the molecular mechanism responsible for Treg expansion in tumors is heterogeneous and unclear. Here, we investigated t...

Yi-Na Liu, Han Zhang, Lin Zhang, Ting-Ting Cai, Dai-Jia Huang… in Cell Death & Disease (2019)

Article

BAG3 promotes autophagy and glutaminolysis via stabilizing glutaminase

Bcl-2 associated athanogene 3 (BAG3) is an important molecule that maintains oncogenic features of cancer cells via diverse mechanisms. One of the important functions assigned to BAG3 is implicated in selectiv...

Song Zhao, Jia-Mei Wang, **g Yan, Da-Lin Zhang, Bao-Qin Liu… in Cell Death & Disease (2019)

Article

Identification of TC2N as a novel promising suppressor of PI3K-AKT signaling in breast cancer

Although TC2N has proven to be an oncogene in lung cancer, its biological function and molecular mechanisms in other cancer still remains unclear. Here, we investigate in breast cancer that TC2N expression is ...

**ang-lin Hao, Li-yun Gao, **ao-juan Deng, Fei Han, Hong-qiang Chen… in Cell Death & Disease (2019)

Article

Dissecting cell diversity and connectivity in skeletal muscle for myogenesis

Characterized by their slow adhering property, skeletal muscle myogenic progenitor cells (MPCs) have been widely utilized in skeletal muscle tissue engineering for muscle regeneration, but with limited efficac...

Yi-xiao Liu, Bing-bing Wu, Lin Gong, Cheng-rui An, Jun-xin Lin… in Cell Death & Disease (2019)

Article

Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans

Brown adipose tissue (BAT) dissipates metabolic energy and mediates non-shivering thermogenesis, thereby boosting energy expenditure. Increasing BAT mass and activity is expected to be a promising strategy for...

Lingyan Wu, Mingfeng **a, Yanan Duan, Lina Zhang, Haowen Jiang… in Cell Death & Disease (2019)

Article

Author Correction: Identification of TC2N as a novel promising suppressor of PI3K-AKT signaling in breast cancer

After publication of this article, it came to the attention of the authors that their names had been reordered. Professor. Jia Cao and Prof. **-yi Liu are the co-corresponding authors, and Prof. **-yi Liu sh...

**ang-lin Hao, Li-yun Gao, **ao-juan Deng, Fei Han, Hong-qiang Chen… in Cell Death & Disease (2019)

Article

Neurons can upregulate Cav-1 to increase intake of endothelial cells-derived extracellular vesicles that attenuate apoptosis via miR-1290

Extracellular vesicles (EVs) including exosomes can serve as mediators of cell–cell communication under physiological and pathological conditions. However, cargo molecules carried by EVs to exert their functio...

Kang-Yi Yue, Pei-Ran Zhang, Min-Hua Zheng, **u-Li Cao, Yuan Cao… in Cell Death & Disease (2019)

Article

Reciprocal regulation of miR-1205 and E2F1 modulates progression of laryngeal squamous cell carcinoma

The burgeoning functions of many microRNAs (miRs) have been well study in cancer. However, the level and function of miR-1205 in laryngeal squamous cell cancer remains unknown. In the current research, we vali...

Pei Li, **-Jun Lin, Yang Yang, An-Kui Yang, **-Ming Di… in Cell Death & Disease (2019)

Article

TNAP inhibition attenuates cardiac fibrosis induced by myocardial infarction through deactivating TGF-β1/Smads and activating P53 signaling pathways

Tissue nonspecific alkaline phosphatase (TNAP) is expressed widely in different tissues, modulating functions of metabolism and inflammation. However, the effect of TNAP on cardiac fibrosis remains controversi...

Lei Gao, Li-you Wang, Zhi-qiang Liu, Dan Jiang, Shi-yong Wu… in Cell Death & Disease (2020)

Article

Inhibition of soluble epoxide hydrolase attenuates renal tubular mitochondrial dysfunction and ER stress by restoring autophagic flux in diabetic nephropathy

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD), and renal tubular cell dysfunction contributes to the pathogenesis of DN. Soluble epoxide hydrolase (sEH) is an enzyme that can...

Xu-shun Jiang, **ng-yang **ang, Xue-mei Chen, Jun-ling He, Ting Liu… in Cell Death & Disease (2020)

Article

LncRNA CRNDE facilitates epigenetic suppression of CELF2 and LATS2 to promote proliferation, migration and chemoresistance in hepatocellular carcinoma

Our study aimed to investigate the expression, functional significance, and related mechanism of long noncoding RNA CRNDE (colorectal neoplasia differentially expressed) in hepatocellular carcinoma (HCC) patho...

Shu-Cai **e, Jian-Quan Zhang, **-Li Jiang, Yong-Yong Hua… in Cell Death & Disease (2020)

Article

TRIM29 inhibits miR-873-5P biogenesis via CYTOR to upregulate fibronectin 1 and promotes invasion of papillary thyroid cancer cells

Papillary thyroid cancer (PTC) is the most common endocrine tumor with an increasing incidence, has a strong propensity for neck lymph node metastasis. Limited treatment options are available for patients with...

Tong Wu, Da-Lin Zhang, Jia-Mei Wang, **g-Yi Jiang, **n Du… in Cell Death & Disease (2020)

Article

Oxygen glucose deprivation/re-oxygenation-induced neuronal cell death is associated with Lnc-D63785 m6A methylation and miR-422a accumulation

Oxygen glucose deprivation/re-oxygenation (OGD/R) induces neuronal injury via mechanisms that are believed to mimic the pathways associated with brain ischemia. In SH-SY5Y cells and primary murine neurons, we ...

Shu Xu, Ya Li, Ju-** Chen, Da-Zhuang Li, Qin Jiang, Ting Wu… in Cell Death & Disease (2020)

Article

RASSF1A inhibits PDGFB-driven malignant phenotypes of nasopharyngeal carcinoma cells in a YAP1-dependent manner

Nasopharyngeal carcinoma (NPC) is a highly aggressive tumor characterized by distant metastasis. Deletion or down-regulation of the tumor suppressor protein ras-association domain family protein1 isoform A (RASSF...

Ying-Ying Liang, Xu-Bin Deng, **an-Tao Lin, Li-Li Jiang… in Cell Death & Disease (2020)

Article

Genome-wide methylation sequencing identifies progression-related epigenetic drivers in myelodysplastic syndromes

The potential mechanism of myelodysplastic syndromes (MDS) progressing to acute myeloid leukemia (AML) remains poorly elucidated. It has been proved that epigenetic alterations play crucial roles in the pathog...

**g-dong Zhou, Ting-juan Zhang, Zi-jun Xu, Zhao-qun Deng, Yu Gu… in Cell Death & Disease (2020)

Article

Systematic evaluation of IgG responses to SARS-CoV-2 spike protein-derived peptides for monitoring COVID-19 patients

Serological tests play an essential role in monitoring and combating the COVID-19 pandemic. Recombinant spike protein (S protein), especially the S1 protein, is one of the major reagents used for serological t...

Yang Li, Dan-yun Lai, Qing Lei, Zhao-wei Xu, Feng Wang… in Cellular & Molecular Immunology (2021)