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Open AccessCRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer
Resistance to chemotherapy has been a major hurdle that limits therapeutic benefits for many types of cancer. Here we systematically identify genetic drivers underlying chemoresistance by performing 30 genome-...
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Article
Open AccessA real-world pharmacovigilance study of FDA adverse event reporting system events for Capmatinib
Capmatinib is a potent selective mesenchymal-epithelial transition inhibitor approved in 2020 for the treatment of metastatic non-small cell lung cancer. As real-world evidence is very limited, this study eval...
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Open AccessMechanoelectronic stimulation of autologous extracellular vesicle biosynthesis implant for gut microbiota modulation
Pathogenic gut microbiota is responsible for a few debilitating gastrointestinal diseases. While the host immune cells do produce extracellular vesicles to counteract some deleterious effects of the microbiota...
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Open AccessAuthor Correction: A comprehensive analysis and experimental validation of TK1 in uterine corpus endometrial carcinoma
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Open AccessLogistic analysis of delayed reporting of emergency blood potassium and comparison of improved outcomes
Potassium testing is an essential test in emergency medicine. Turnaround time (TAT) is the time between specimen receipt by the laboratory and the release of the test report. A brief in-laboratory TAT increase...
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Open AccessA comprehensive analysis and experimental validation of TK1 in uterine corpus endometrial carcinoma
Uterine corpus endometrial carcinoma (UCEC) is becoming a main malignant cancer that threaten to women's health. Thymidine kinase 1 (TK1) is considering to be associated with tumorigenesis and development. Nev...
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Open AccessInorganic perovskite-based active multifunctional integrated photonic devices
The development of highly efficient active integrated photonic circuits is crucial for advancing information and computing science. Lead halide perovskite semiconductors, with their exceptional optoelectronic ...
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Article
Open AccessDownregulation of Roundabout guidance receptor 2 suppresses hepatocellular carcinoma progression by interacting with Y-box binding protein 1
Roundabout guidance receptor 2 (Robo2) is closely related to malignant tumors such as pancreatic cancer and liver fibrosis, but there is no relevant research on the role of Robo2 in HCC. The study will further...
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Open AccessNeutrophil activation and clonal CAR-T re-expansion underpinning cytokine release syndrome during ciltacabtagene autoleucel therapy in multiple myeloma
Cytokine release syndrome (CRS) is the most common complication of chimeric antigen receptor redirected T cells (CAR-T) therapy. CAR-T toxicity management has been greatly improved, but CRS remains a prime saf...
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Open AccessIdentification of a cancer associated fibroblasts-related index to predict prognosis and immune landscape in ovarian cancer
Cancer-associated fibroblasts (CAFs) play a role in ovarian cancer (OV) evolution, immunosuppression and promotion of drug resistance. Exploring the value of CAFs-related biomarker in OV is of great importance...
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Open AccessResearch on blasting mechanism and blasting effect of aqueous media in open pit coal mines
Surface coal mining procedures include piercing—blasting—mining and loading—transportation—discharging, blasting link exists due to the poor blasting effect leads to low loading efficiency, blasting dust cause...
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Open AccessAuthor Correction: Sustained antidepressant effect of ketamine through NMDAR trap** in the LHb
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Open AccessSustained antidepressant effect of ketamine through NMDAR trap** in the LHb
Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist1, has revolutionized the treatment of depression because of its potent, rapid and sustained antidepressant effects2–4. Although the elimination half-l...
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Open AccessEstimating residual undifferentiated cells in human chemically induced pluripotent stem cell derived islets using lncRNA as biomarkers
Human pluripotent stem cells (hPSCs) can generate insulin-producing beta cells for diabetes treatment, but residual undifferentiated cells may cause tumors. We developed a highly sensitive assay to detect thes...
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Open AccessControl of arbuscule development by a transcriptional negative feedback loop in Medicago
Most terrestrial plants establish a symbiosis with arbuscular mycorrhizal fungi (AMF), which provide them with lipids and sugars in exchange for phosphorus and nitrogen. Nutrient exchange must be dynamically c...
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Open AccessNon cancer causes of death after gallbladder cancer diagnosis: a population-based analysis
Mortality from non cancer causes in patients with gallbladder cancer (GBC) still unclear. This study evaluated the causes and risk factors of non cancer death during different follow-up periods after GBC diagn...
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Open AccessEvaluation on coupling coordinated development of population economy and eco-geological environment in the twin-city economic circle of Chengdu–Chongqing region
Using the CRITIC method, comprehensive index evaluation method, VAR model, coupling coordination model and other methods, this paper evaluates the comprehensive development of the population economy and eco-ge...
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Open AccessPXL1 and SERKs act as receptor–coreceptor complexes for the CLE19 peptide to regulate pollen development
Gametophyte development in angiosperms occurs within diploid sporophytic structures and requires coordinated development; e.g., development of the male gametophyte pollen depends on the surrounding sporophytic...
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Open AccessCombination of Lactobacillus fermentum NS9 and aronia anthocyanidin extract alleviates sodium iodate-induced retina degeneration
It is important to explore the effective approaches to prevent dry age-related macular degeneration (AMD). In this study, significantly decreased full-field electroretinograms wave amplitudes and disordered re...
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Open AccessPolarization-directed growth of spiral nanostructures by laser direct writing with vector beams
Chirality is pivotal in nature which attracts wide research interests from all disciplines and creating chiral matter is one of the central themes for chemists and material scientists. Despite of significant e...