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Chapter
Dynamics of Spray Granulation in Continuously Operated Horizontal Fluidized Beds
This chapter presents new findings on process and product design in continuous spray layering granulation in horizontal fluidized beds. The results are achieved by a multi-scale approach, combining single-part...
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Article
Dual-energy electron beams from a compact laser-driven accelerator
Ultrafast pump–probe experiments open the possibility to track fundamental material behaviour, such as changes in electronic configuration, in real time. To date, most of these experiments are performed using ...
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Article
Open AccessPosition statement on radiopharmaceutical production for clinical trials
The EU regulation 536/2014 aims to facilitate the experimental use of diagnostic radiopharmaceuticals in particular for GMP requirements and needs to be applied in EU countries. As definitely clarified by this...
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Article
A rapid ex vivo tissue model for optimising drug detection and ionisation in MALDI imaging studies
The aim of this study was to establish an ex vivo model for a faster optimisation of sample preparation procedures, for example matrix choice, in matrix-assisted laser desorption/ionisation (MALDI) drug imagin...
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Article
Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression
The cysteine protease cathepsin B (CTSB) is frequently overexpressed in human breast cancer and correlated with a poor prognosis. Genetic deficiency or pharmacological inhibition of CTSB attenuates tumor growt...
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Article
Smoking but not cocaine use is associated with lower cerebral metabotropic glutamate receptor 5 density in humans
Long-lasting neuroadaptations in the glutamatergic corticostriatal circuitry have been suggested to be responsible for the persisting nature of drug addiction. In particular, animal models have linked the meta...
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Article
Moyamoya disease and Moyamoya syndrome: experience in Europe; choice of revascularisation procedures
To present our clinical experience in terms of disease presentation and choice of revascularisation procedure in our first group of 23 European Moyamoya angiopathy (disease and syndrome) patients.
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Chapter and Conference Paper
Intensification of the Conditioning Regimen for Patients with high-risk AML and MDS: 3 year Experience of using an188 Re — Labelled anti — CD 66 Monoclonal Antibody
We have intensified the conditioning regimen prior to stem cell transplantation in 42 patients with high-risk AML and MDS by treating patients with a 188 Re — labeled anti — CD 66 monoclonal antibody. Dosimetry w...
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Article
PET attenuation coefficients from CT images: experimental evaluation of the transformation of CT into PET 511-keV attenuation coefficients
The CT data acquired in combined PET/CT studies provide a fast and essentially noiseless source for the correction of photon attenuation in PET emission data. To this end, the CT values relating to attenuatio...
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Article
Initial results in the assessment of multiple myeloma using 18F-FDG PET
This prospective study was undertaken to investigate the appearance of multiple myeloma on fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET). Furthermore, the accuracy of FDG-PET in detect...
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Article
Whole-body positron emission tomography using fluorodeoxyglucose for staging of lymphoma: effectiveness and comparison with computed tomography
The purpose of this study was to evaluate whole-body positron emission tomography (WB-PET) as a staging modality in Hodgkin’s disease (HD) and non-Hodgkin lymphoma (NHL) and to compare it with computed tomogr...
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Article
Quantitative evaluation of manganese-52m as a myocardial perfusion tracer in pigs using positron emission tomography
There is a need for a quantitative myocardial perfusion agent that does not require an on-site cyclotron. Early studies with manganese demonstrated that this trace metal is of potential use for myocardial imag...
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Chapter and Conference Paper
Expression von C-erbB Rezeptoren (EGF-R, C-erbB2), TGFα und P53 während der experimentellen Karzinogenese des primären Leberkarzinoms
Die Hepatokarzinogenese ist ein über mehrere Jahre verlaufender, auf morphologisch unterscheidbaren, präneoplastischen Läsionen aufbauender Prozess. Auf molekularer Ebene wurden bisher verschiedene, diesen Pro...
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Chapter
Effect of Transmeridian Flights: Objective and Subjective Sleep Parameters
Present-day aircraft operating around northern and southern latitudes cross time zones almost at the same rate as the earth rotates. Journeys between continents can be completed within a few hours, and a shift...
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Chapter and Conference Paper
Impaired Myocardial Ultrastructure and Cytoskeleton in Cardiomyopathic Human Myocardium
In dilated cardiomyopathy the principal morphologic changes are hypertrophy of myocytes, increased content of connective tissue, i. e., fibrosis, and degeneration of subcellular myocardial components. In recen...
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Article
Buchbesprechungen
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Article
Peter Grassmann zum 75. Geburtstag
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Article
Orally administered melatonin stimulates the 3α/β-hydroxysteroid oxidoreductase but not the 5α-reductase in the ventral prostate and seminal vesicles of pinealectomized rats
Pinealectomized rats were treated orally with melatonin (MEL) for 14 days. Prostates and seminal vesicles were investigated for the activity of the δ 4-3-ketosteroid-5α-oxidoreductase (5α-R) and of the 3α/β-hy...
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Article
Nachweis spezifischer cytophiler antikörper bei penicillin-allergikern mit einem modifizierten rosettentest
Penicillin allergies can be verified only to a limited extent by means of the present test methods. In order to enlarge the number of immunologically traceable penicillin allergies, the rosette technique (Boyd...
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Article
Zum Nachweis cytophiler heterophiler Antikörper bei Psoriatikern
Incubation of washed sheep erythrocytes (Behring-Werke, Marburg) with leucocytes and serum was performed in psoriatic patients and a control group. On microscopic slides an adherence of erythrocytes to leucocy...
