77 Result(s)

Article

Nicotinamide adenine dinucleotide replenishment rescues colon degeneration in aged mice

Susceptibility of gastrointestinal dysmotility increases with age-associated colonic degeneration. A paucity of remedies reversing colonic degeneration per se hinders the fundamental relief of symptoms. Here we d...

Xudong Zhu, Weiyan Shen, Ying Wang… in Signal Transduction and Targeted Therapy (2017)

Article

Sympathetic transmitters control thermogenic efficacy of brown adipocytes by modulating mitochondrial complex V

Obesity is a worldwide epidemic and results from excessive energy intake or inefficient energy expenditure. It is promising to utilize the thermogenic function of brown adipose tissue for obesity intervention....

Tao-Rong **e, Chun-Feng Liu, Jian-Sheng Kang in Signal Transduction and Targeted Therapy (2017)

Article

History and progress of hypotheses and clinical trials for Alzheimer’s disease

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its main pathological features a...

Pei-Pei Liu, Yi **e, **ao-Yan Meng… in Signal Transduction and Targeted Therapy (2019)

Article

The effect of selective serotonin reuptake inhibitors on cognitive function in patients with Alzheimer’s disease and vascular dementia: focusing on fluoxetine with long follow-up periods

Yi **e, Pei-Pei Liu, Ya-Jun Lian, Hong-Bo Liu… in Signal Transduction and Targeted Therapy (2019)

Article

Author Correction: History and progress of hypotheses and clinical trials for Alzheimer’s disease

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Pei-Pei Liu, Yi **e, **ao-Yan Meng… in Signal Transduction and Targeted Therapy (2019)

Article

Human herpesvirus 4 and adaptive immunity in Alzheimer’s disease

Jian-Sheng Kang, Pei-Pei Liu in Signal Transduction and Targeted Therapy (2020)

Article

Bcl-3 promotes Wnt signaling by maintaining the acetylation of β-catenin at lysine 49 in colorectal cancer

Wnt/β-catenin signaling plays a critical role in colorectal cancer (CRC) tumorigenesis and the homeostasis of colorectal cancer stem cells (CSCs), but its molecular mechanism remains unclear. B-cell lymphoma 3...

** Chen, Chen Wang, Yuhang Jiang, Qi Wang… in Signal Transduction and Targeted Therapy (2020)

Article

Temporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients

Zhi-Sheng Xu, Ting Shu, Liang Kang, Di Wu… in Signal Transduction and Targeted Therapy (2020)

Article

Crystal structure of SARS-CoV-2 nsp10/nsp16 2′-O-methylase and its implication on antiviral drug design

Sheng Lin, Hua Chen, Fei Ye, Zimin Chen… in Signal Transduction and Targeted Therapy (2020)

Article

Identification of a hotspot on PD-L1 for pH-dependent binding by monoclonal antibodies for tumor therapy

Hongchuan Liu, **aoshan Bi, Yuehua Zhou… in Signal Transduction and Targeted Therapy (2020)

Article

IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas

The insulin-like growth factor 1 receptor (IGF-1R) governs several signaling pathways for cell proliferation, survival, and anti-apoptosis. Thus, targeting IGF-1R appears as a reasonable rationale for tumor tr...

Qing Wang, Yan Zhang, Jiang Zhu, Honggang Zheng… in Signal Transduction and Targeted Therapy (2020)

Article

Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial

No effective drug treatments are available for coronavirus disease 2019 (COVID-19). Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage, death, or long...

Fan** Meng, Ruonan Xu, Siyu Wang, Zhe Xu… in Signal Transduction and Targeted Therapy (2020)

Article

Epitranscriptomics and epiproteomics in cancer drug resistance: therapeutic implications

Drug resistance is a major hurdle in cancer treatment and a key cause of poor prognosis. Epitranscriptomics and epiproteomics are crucial in cell proliferation, migration, invasion, and epithelial–mesenchymal ...

Huibin Song, Dongcheng Liu, Shaowei Dong… in Signal Transduction and Targeted Therapy (2020)

Article

Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS

Although stress has been known to increase the susceptibility of pathogen infection, the underlying mechanism remains elusive. In this study, we reported that restraint stress dramatically enhanced the morbidi...

Zhuo Luo, Li-Fang Liu, Ying-Nan Jiang… in Signal Transduction and Targeted Therapy (2020)

Article

Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice

In vertebrates, the type 1 parathyroid hormone receptor (PTH1R) is a critical regulator of skeletal development and homeostasis; however, how it is modulated is incompletely understood. Here we report that del...

Xuekun Fu, Bo Zhou, Qinnan Yan, Chu Tao… in Signal Transduction and Targeted Therapy (2020)

Article

P21-activated kinase 5 potentiates the chemoresistant phenotype of liver cancer

Ding-Guo Zhang, Chan-Chan Gong, **ao-** Wu… in Signal Transduction and Targeted Therapy (2021)

Article

Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients: a randomized, double-blind, placebo-controlled phase 2 trial

Treatment of severe Coronavirus Disease 2019 (COVID-19) is challenging. We performed a phase 2 trial to assess the efficacy and safety of human umbilical cord-mesenchymal stem cells (UC-MSCs) to treat severe C...

Lei Shi, Hai Huang, Xuechun Lu, **aoyan Yan… in Signal Transduction and Targeted Therapy (2021)

Article

SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer

Alternative splicing is a critical process to generate protein diversity. However, whether and how alternative splicing regulates autophagy remains largely elusive. Here we systematically identify the splicing...

Yuesheng Lv, Wen**g Zhang, **yao Zhao… in Signal Transduction and Targeted Therapy (2021)

Article

HLA-mismatched allogeneic adoptive immune therapy in severely immunosuppressed AIDS patients

Severely immunosuppressed AIDS patients with recurrent opportunistic infections (OIs) represent an unmet medical need even in the era of antiretroviral therapy (ART). Here we report the development of a human ...

Ruonan Xu, Ji-Yuan Zhang, Bo Tu, Zhe Xu… in Signal Transduction and Targeted Therapy (2021)

Article

Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Blocking CD147 via anti-CD147 antibody could suppress the in vitro SAR...

Huijie Bian, Zhao-Hui Zheng, Ding Wei… in Signal Transduction and Targeted Therapy (2021)