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Clinical significance and regulation of the costimulatory molecule B7-H3 in human colorectal carcinoma
B7-H3, a member of the B7-family molecules, plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 was expresse...
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Article
Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer
To establish the prognostic value of B7-H4 expression by tumor cells in gastric cancer patients, we evaluated the association of B7-H4 expression with clinicopathologic factors and overall survival of gastric ...
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Article
Open AccessComputed tomography-guided permanent brachytherapy for locoregional recurrent gastric cancer
Locoregional recurrence is the typical pattern of recurrence in gastric cancer, and cannot be removed by surgery in most of the patients. We aimed to evaluate the feasibility and efficacy of computed tomograph...
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Article
Open AccessEfficacy of adjuvant immunotherapy with cytokine-induced killer cells in patients with locally advanced gastric cancer
To determine the long-term efficacy of adjuvant immunotherapy with autologous cytokine-induced killer (CIK) cells for locally advanced gastric cancer patients.
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Article
Higher numbers of T-bet+ intratumoral lymphoid cells correlate with better survival in gastric cancer
In the present study, we studied the expression of T-bet, a key marker for type 1 immune responses, within the tumor microenvironment of gastric cancer, and analyzed its association with clinicopathological pa...
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Article
Open AccessRETRACTED ARTICLE: Up-regulated miR-199a-5p in gastric cancer functions as an oncogene and targets klotho
Recent studies have shown that miR-199a-5p plays opposite roles in cancer initiation and progression of different cancer types, acting as oncogene for some cancer types but as tumor suppressor gene for others....
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Article
Circulating microRNA Testing for the Early Diagnosis and Follow-up of Colorectal Cancer Patients
Early detection of colorectal cancer (CRC) is key for prevention and the ability to impact long-term survival of CRC patients. However, the compliance rate of recommended colonoscopy for the population aged fr...
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Article
Expression of costimulatory molecules B7-H1, B7-H4 and Foxp3+ Tregs in gastric cancer and its clinical significance
Immune escape plays an important role in tumor progression. In the present study, the expression of B7-H1, B7-H4 and Foxp3 involved in immune escape in gastric carcinoma was investigated and the corresponding ...
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Article
Open AccessLack of association between bovine leukemia virus and breast cancer in Chinese patients
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Article
Open AccessA prediction model for lymph node metastases using pathologic features in patients intraoperatively diagnosed as stage I non-small cell lung cancer
There is little information on which pattern should be chosen to perform lymph node dissection for stage I non-small-cell lung cancer. This study aimed to develop a model for predicting lymph node metastasis u...
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Article
Interleukin-33 Expression does not Correlate with Survival of Gastric Cancer Patients
The aim of the study was to investigate IL-33 expression in gastric cancer (GC) and its association with the clinical characteristics and the prognosis. IL-33 protein in tumor and corresponding adjacent tissue...
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Article
Open AccessCTHRC1 induces non-small cell lung cancer (NSCLC) invasion through upregulating MMP-7/MMP-9
The strong invasive and metastatic nature of non-small cell lung cancer (NSCLC) leads to poor prognosis. Collagen triple helix repeat containing 1 (CTHRC1) is involved in cell migration, motility and invasion....
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Article
Open AccessFunction and clinical significance of circRNAs in solid tumors
Circular RNA (circRNA) is a new type of endogenous non-coding RNAs (ncRNAs). circRNA regulates gene expression in many biological processes, and it also participates in the initiation and development of variou...
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Article
Open AccessExpression of B7-H6 expression in human hepatocellular carcinoma and its clinical significance
Recent studies have suggested that B7-H6, a new member of the B7 family of ligands, not only is a crucial regulator of NK cell-mediated immune responses but also has important clinical implications due to its ...
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Open AccessCorrection to: Expression of B7-H6 expression in human hepatocellular carcinoma and its clinical significance
Following publication of the original article [1], the authors reported a ty** mistake in the title. In this Correction the incorrect and correct titles are shown.
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Article
Open AccessDecreased RIG-I expression is associated with poor prognosis and promotes cell invasion in human gastric cancer
Retinoic acid-induced protein I (RIG-I), known as a cytoplastic pattern recognition receptor, can recognize exogenous viral RNAs, and then initiate immune response. Recently, numerous studies also showed that ...
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Article
Open AccessCirculating tumor cells with karyoty** as a novel biomarker for diagnosis and treatment of nasopharyngeal carcinoma
Circulating tumor cells (CTCs) have been considered great clinical significance in various cancers. However, it remains unknown that how is the role of CTCs in patients with nasopharyngeal carcinoma (NPC). We ...
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Article
Open AccessAberrant fatty acid profile and FFAR4 signaling confer endocrine resistance in breast cancer
Evidence suggests that fatty acid receptor FFAR4 plays a tumor-promoting role in adipose tissue-adjacent malignancies, but its clinical relevance remains unexplored. Here, we investigated the clinical signific...
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Article
Open AccessMiR-1180 from bone marrow MSCs promotes cell proliferation and glycolysis in ovarian cancer cells via SFRP1/Wnt pathway
The ovarian cancer microenvironment is responsible for cancer cell growth and disease relapse. Bone marrow mesenchymal stem cells (BM-MSCs) play important roles in ovarian cancer, however, the mechanism of BM-...
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Open AccessA novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling
It has been well established that circular RNAs (circRNAs) play an important regulatory role during tumor progression. Recent studies have indicated that even though circRNAs generally regulate gene expression...