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Long Non-coding RNAs in Cancer

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Handbook of Oncobiology: From Basic to Clinical Sciences

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Abstract

Long non-coding RNAs (lncRNAs) are emerging as cardinal biomarkers for diagnosis, prognosis, and therapy of cancers as well as precise therapeutic targets against cancers. Through their interactions with multiple macromolecules in the cell, they regulate diverse array of cellular responses. Dysregulated expression and functional regulation of the lncRNAs have been associated with the genesis and progression of many cancers. Their potential to form vast network of interactomes involving DNA, RNA, and proteins enables them to have a complex functional repertoire. LncRNAs localize within the nucleus, cytosol, and other subcellular compartments to execute their functions in regulating tumor genesis and progression. LncRNAs act as molecular signals, guides, scaffolds, and decoys in executing either the tumor-promoting or -suppressing roles within the cancer cells. However, further advancements are required for pre-clinical validations that can warrant lncRNA-based therapeutics for the clinical trials. This book chapter reviews the diverse mechanisms of action, both within the nucleus and the cytoplasm, that enables them to regulate tumorigenesis.

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Acknowledgments

Funding: The present research was supported by the Department of Defense Ovarian Cancer Research Program Award (grant no. W81XWH-18-1-0066). Computational services were supported by the National Institute of General Medical Sciences P20 (NIGMS P20 GM103639) and The National Cancer Institute of the National Institutes of Health (NCI P30 CA225520). The figures were created by the authors using BioRender.com under academic license.

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Authors and Affiliations

  1. Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    Revathy Nadhan & Danny N. Dhanasekaran

  2. Laboratory of Molecular Pathology and NanoBioImaging, Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy

    Ciro Isidoro

  3. Department of Obstetrics and Gynecology, Cancer Research Institute, College of Medicine, Seoul National University, Seoul, South Korea

    Yong Sang Song

  4. Department of Cell Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    Danny N. Dhanasekaran

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  1. Revathy Nadhan
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  4. Danny N. Dhanasekaran
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Correspondence to Danny N. Dhanasekaran .

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Editors and Affiliations

  1. Dept. Biotechnology, Panjab University, Chandigarh, Chandigarh, India

    R. C. Sobti

  2. NCR Biotech Science Cluster, Translational Health Sci & Tech Inst, Faridabad, Haryana, India

    Nirmal K. Ganguly

  3. Cancer Research Institute, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India

    Rakesh Kumar

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  1. Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, India

    Siddharth Sharma

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Nadhan, R., Isidoro, C., Song, Y.S., Dhanasekaran, D.N. (2023). Long Non-coding RNAs in Cancer. In: Sobti, R.C., Ganguly, N.K., Kumar, R. (eds) Handbook of Oncobiology: From Basic to Clinical Sciences. Springer, Singapore. https://doi.org/10.1007/978-981-99-2196-6_37-1

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