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Mice as Experimental Models for Cancer Research

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Handbook of Animal Models and its Uses in Cancer Research

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Abstract

Cancer is a devastating disease affecting a large number of people worldwide. There has been relentless effort to learn various aspects of the development of the disease as well as how to combat it in various ways. In that process, ideal models for cancer research were first in harness. Because of several advantages, inbred mouse strain (Mus musculus) has proved to be an ideal animal model to investigate changes in different tissues during and after development of cancer induced by different carcinogens or by genetic manipulation, yielding possibilities of intercepting it at specific steps preventing advancement of the disease by modulating physiological and tissue-specific regulation of genes. Carcinogen-induced cancer models are most suited and generally used to assess the therapeutic properties of drugs, explore precautionary actions for carcinogenicity, and understand molecular mechanisms involved in various types of cancer. Initial manipulation of gene expression in mouse genome resulted in production of transgenic mice categorized by the constitutive expression of a particular gene and knockout mice characterized by the ablation of a specific gene. These planned mouse models are projected to serve as a foundation for additional exploration of the molecular basis of human diseases. The present chapter is mainly focused on the principles, advancement, and application of currently conducted researches deployed in the conditional regulation of gene expression in the investigation of cancer.

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Authors and Affiliations

  1. Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani, West Bengal, India

    Anisur Rahman Khuda-Bukhsh, Jayeeta Das & Asmita Samadder

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  1. Anisur Rahman Khuda-Bukhsh
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  2. Jayeeta Das
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  3. Asmita Samadder
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Editors and Affiliations

  1. Allied Health Sciences, CARE, Chennai, Tamil Nadu, India

    Surajit Pathak

  2. Fac of Allied Health Sciences, CHRI, Chettinad Acad of Res & Education, Kelambakkam, Chennai, Tamil Nadu, India

    Antara Banerjee

  3. AGENTEM, Cukurova University, Adana, Turkey

    Atil Bisgin

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Khuda-Bukhsh, A.R., Das, J., Samadder, A. (2022). Mice as Experimental Models for Cancer Research. In: Pathak, S., Banerjee, A., Bisgin, A. (eds) Handbook of Animal Models and its Uses in Cancer Research. Springer, Singapore. https://doi.org/10.1007/978-981-19-1282-5_5-1

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  • DOI: https://doi.org/10.1007/978-981-19-1282-5_5-1

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