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Cancer Stem Cells in Therapy Resistance of Colorectal Cancer

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide, and therapy resistance is one of the most common reasons for treatment failure in CRC. Cancer stem cells (CSCs) are a minor subpopulation of tumor cells with the capacity of self-renewal and differentiation, which play an important role in the progression, recurrence, and therapy resistance of cancer. Recent studies have shown that CSCs induce cancer resistance to conventional treatments through a variety of mechanisms, including targeting signaling pathways, regulating level of microRNAs, DNA damage repair, maintaining low levels of reactive oxygen species (ROS), and maintaining a relatively quiescent state. Therefore, therapeutic strategies targeting CSCs may be able to reverse therapy resistance of CRC, but the lack of specific CSC markers also confuses this therapeutic strategy. In this chapter, we will discuss the effect of CSCs on CRC therapy resistance and its potential mechanism, the current research progress of the strategy of targeting CSCs, and their existing problems in order to provide a reference for the selection of therapeutic strategies for CRC.

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Abbreviations

ABCG2:

ATP-binding cassette super-family G member 2

ABCB5:

ATP-binding cassette member B5

ABC:

ATP-binding cassette proteins

AML:

Acute myeloid leukemia

APC:

Adenomatous polyposis coli

BCC:

Basal cell carcinoma

BCL2:

B-cell lymphoma 2

CRC:

Colorectal cancer

CSCs:

Cancer stem cells

CD133:

Cluster of differentiation 133

CD44:

Cluster of differentiation 44

COX-2:

Cyclooxygenase-2

FOXO3a:

Forkhead transcription factor forkhead box O3a

GSK3:

Glycogen synthase kinase 3

5-FU:

5-Fluorouracil

IGF1-R:

Growth factor 1 receptor

LGR5:

Leucine-rich repeat-containing G-protein-coupled receptor 5

miRNA:

MicroRNAs

MTX:

Methotrexate

MMP16:

Matrix metalloproteinase 16

MDR:

Multidrug resistance

MRP-2:

MDR-associated protein 2

ROS:

Reactive oxygen species

SMO:

Smoothened

SP:

Side population

TDX:

Tomudex

TUSC3:

Tumor suppressor candidate 3

3'UTR:

3' untranslated region

YAP:

Yes-associated protein

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Authors and Affiliations

  1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China

    Ying Yang, Wen-Jian Meng & Zi-Qiang Wang

Authors
  1. Ying Yang
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  2. Wen-Jian Meng
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  3. Zi-Qiang Wang
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Editor information

Editors and Affiliations

  1. Dept Biochem & Biophysics, C-Block, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. Cellular Stress and Immune Response Laboratory, Centre for Cancer Biology, University of South Australia, Adelaide, South Australia, Australia

    Nirmal Robinson

  2. Department of Morphofunctional Sciences, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania

    Cornelia Amalinei

  3. Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana State, India

    Amitava Das

  4. Biological Sciences, Academy of Scientific and Innovative Research, Ghaziabad,, UP, India

    Amitava Das

  5. Chettinad Hospital & Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Chennai, Tamil Nadu, India

    Surajit Pathak

  6. Stem Cell Facility, DBT-Centre of Excellence for Stem Cell Research, All India Institute of Medical Sciences, New Delhi, India

    Sujata Mohanty

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Yang, Y., Meng, WJ., Wang, ZQ. (2021). Cancer Stem Cells in Therapy Resistance of Colorectal Cancer. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-1247-3_102-1

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  • DOI: https://doi.org/10.1007/978-981-16-1247-3_102-1

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-16-1247-3

  • Online ISBN: 978-981-16-1247-3

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