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Prostate Cancer Targeted Therapy

  • Reference work entry
  • First Online:
Encyclopedia of Cancer

  • 103 Accesses

Definition

Targeted therapy represents an attractive option for cancer patients. It is designed specifically to target the hallmark or active pathway of cancer cells without toxicity to normal cells, through which the patients can be expected to benefit from improved outcomes with minimized treatment related side effects.

Characteristics

Prostate cancer is the leading type of cancer and second leading cause of cancer related death among men in Western world. Initially, the conventional treatment involving androgen deprivation therapy alleviates the disease temporarily but eventually results in recurrence of highly aggressive and castration-resistant metastatic cancer, for which no curative therapy exists currently. Thus, there is an urgent need for new therapeutic approaches to be developed for patients with castration-resistant prostate cancer.

In the last decade, much has been learned about molecular pathways and biological mechanisms of prostate cancer progression and this provides...

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References

  • Antonarakis ES, Carducci MA, Eisenberger MA (2010) Novel targeted therapeutics for metastatic castration-resistant prostate cancer. Cancer Lett 291(1):1–13

    Article  CAS  PubMed  Google Scholar 

  • Elsässer-Beile U, Bühler P, Wolf P (2009) Targeted therapies for prostate cancer against the prostate specific membrane antigen. Curr Drug Targets 10(2):118–125

    Article  PubMed  Google Scholar 

  • Horoszewicz JS, Kawinski E, Murphy GP (2009) Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients. Anticancer Res 7(5B):927–935

    Google Scholar 

  • Morgan TM, Koreckij TD, Corey E (2009) Targeted therapy for advanced prostate cancer: inhibition of the PI3K/Akt/mTOR pathway. Curr Cancer Drug Targets 9(2):237–249

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ramsay AK, Leung HY (2009) Signalling pathways in prostate carcinogenesis: potentials for molecular-targeted therapy. Clin Sci (Lond) 117(6):209–228

    Article  CAS  Google Scholar 

  • Stavridi F, Karapanagiotou EM, Syrigos KN (2010) Targeted therapeutic approaches for hormone-refractory prostate cancer. Cancer Treat Rev 36(2):122–130

    Article  CAS  PubMed  Google Scholar 

  • Sun A, Tang J, Terranova PF, Zhang X, Thrasher JB, Li B (2010) Adeno-associated virus-delivered short hairpin-structured RNA for androgen receptor gene silencing induces tumor eradication of prostate cancer xenografts in nude mice: a preclinical study. Int J Cancer 126(3):764–774

    Article  CAS  PubMed  Google Scholar 

  • Thorpe PE (2004) Vascular targeting agents as cancer therapeutics. Clin Cancer Res 10(2):415–427

    Article  PubMed  Google Scholar 

See Also

  • (2012) AKT. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 115. doi:10.1007/978-3-642-16483-5_163

    Google Scholar 

  • (2012) Basic fibroblast Growth Factor. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 349. doi:10.1007/978-3-642-16483-5_539

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  • (2012) Estramustine. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 1327. doi:10.1007/978-3-642-16483-5_2013

    Google Scholar 

  • (2012) Monoclonal Antibody. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2367. doi:10.1007/978-3-642-16483-5_6842

    Google Scholar 

  • (2012) Monoclonal Antibody Therapy. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, pp 2367–2368. doi:10.1007/978-3-642-16483-5_3823

    Google Scholar 

  • (2012) MTOR. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 2384. doi:10.1007/978-3-642-16483-5_3867

    Google Scholar 

  • (2012) Prostatic Acid Phosphatase. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 3072. doi:10.1007/978-3-642-16483-5_6777

    Google Scholar 

  • (2012) Renal cancer. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, pp 3225–3226. doi:10.1007/978-3-642-16483-5_6575

    Google Scholar 

  • (2012) Sipuleucel-T. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 3413. doi:10.1007/978-3-642-16483-5_6776

    Google Scholar 

  • (2012) Sunitinib. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 3562. doi:10.1007/978-3-642-16483-5_5575

    Google Scholar 

  • (2012) Targeted Therapy. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 3610. doi:10.1007/978-3-642-16483-5_5677

    Google Scholar 

  • (2012) Transcription. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3752. doi:10.1007/978-3-642-16483-5_5899

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Urology, The University of Kansas Medical Center, Kansas City, KS, USA

    Benyi Li

Authors
  1. Benyi Li
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Corresponding author

Correspondence to Benyi Li .

Editor information

Editors and Affiliations

  1. German Cancer Research Center (DKFZ), Tumorgenetik, Heidelberg, Germany

    Manfred Schwab

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Li, B. (2016). Prostate Cancer Targeted Therapy. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46875-3_6826

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