Definition
SWEET transporters = a family of transporters for glycosides that typically use a uniport transport mechanism. Their physiological function is often in cellular efflux, for example, as the first step in phloem loading in plants, but can also be in cellular import, for example, into the endosperm in maize:
Soluble carbohydrates, principally derived from photosynthesis, serve as the preferred form of carbon nutrient for many unicellular organisms and as the dominant transport form for carbon and energy in multicellular organisms. Almost all cells from all kingdoms use carrier proteins to transport soluble carbohydrates across the lipid bilayers that enclose their cytoplasm (Chen et al. 2015a). Today, at least five classes of carriers...
References
Antony G, Zhou J, Huang S, Li T, Liu B, White F, Yang B (2010) Rice xa13 recessive resistance to bacterial blight is defeated by induction of the disease susceptibility gene Os-11N3. Plant Cell 22:3864–3876. https://doi.org/10.1105/tpc.110.078964
Chen LQ, Hou BH, Lalonde S, Takanaga H, Hartung ML, Qu XQ, Guo WJ, Kim JG, Underwood W, Chaudhuri B, Chermak D, Antony G, White FF, Somerville SC, Mudgett MB, Frommer WB (2010) Sugar transporters for intercellular exchange and nutrition of pathogens. Nature 468:527–532. https://doi.org/10.1038/nature09606
Chen LQ, Qu XQ, Hou BH, Sosso D, Osorio S, Fernie AR, Frommer WB (2012) Sucrose efflux mediated by SWEET proteins as a key step for phloem transport. Science 335:207–211. https://doi.org/10.1126/science.1213351
Chen L-Q, Cheung LS, Feng L, Tanner W, Frommer WB (2015a) Transport of sugars. Annu Rev Biochem 84:865–894. https://doi.org/10.1146/annurev-biochem-060614-033904
Chen L-Q, Lin IW, Qu X-Q, Sosso D, McFarlane HE, Londoño A, Samuels AL, Frommer WB (2015b) A cascade of sequentially expressed sucrose transporters in the seed coat and endosperm provides nutrition for the Arabidopsis embryo. Plant Cell 27:607–619. https://doi.org/10.1105/tpc.114.134585
Cohn M, Bart RS, Shybut M, Dahlbeck D, Gomez M, Morbitzer R, Hou B-H, Frommer WB, Lahaye T, Staskawicz BJ (2014) Xanthomonas axonopodis virulence is promoted by a transcription activator-like effector-mediated induction of a SWEET sugar transporter in cassava. Mol Plant-Microbe Interact 27:1186–1198. https://doi.org/10.1094/MPMI-06-14-0161-R
Cox KL, Meng F, Wilkins KE, Li F, Wang P, Booher NJ, Carpenter SCD, Chen L-Q, Zheng H, Gao X, Zheng Y, Fei Z, Yu JZ, Isakeit T, Wheeler T, Frommer WB, He P, Bogdanove AJ, Shan L (2017) TAL effector driven induction of a SWEET gene confers susceptibility to bacterial blight of cotton. Nat Commun 8:15588. https://doi.org/10.1038/ncomms15588
Feng L, Frommer WB (2015) Structure and function of SemiSWEET and SWEET sugar transporters. Trends Biochem Sci 40:480–486. https://doi.org/10.1016/j.tibs.2015.05.005
Han L, Zhu Y, Liu M, Zhou Y, Lu G, Lan L, Wang X, Zhao Y, Zhang XC (2017) Molecular mechanism of substrate recognition and transport by the AtSWEET13 sugar transporter. Proc Natl Acad Sci U S A. https://doi.org/10.1073/pnas.1709241114
Hu Y-B, Sosso D, Qu X-Q, Chen L-Q, Ma L, Chermak D, Zhang D-C, Frommer WB (2016) Phylogenetic evidence for a fusion of archaeal and bacterial SemiSWEETs to form eukaryotic SWEETs and identification of SWEET hexose transporters in the amphibian chytrid pathogen Batrachochytrium dendrobatidis. J Off Publ Fed Am Soc Exp Biol 30:3644–3654. https://doi.org/10.1096/fj.201600576R
Kanno Y, Oikawa T, Chiba Y, Ishimaru Y, Shimizu T, Sano N, Koshiba T, Kamiya Y, Ueda M, Seo M (2016) AtSWEET13 and AtSWEET14 regulate gibberellin-mediated physiological processes. Nat Commun 7:13245. https://doi.org/10.1038/ncomms13245
Latorraca NR, Fastman NM, Venkatakrishnan AJ, Frommer WB, Dror RO, Feng L (2017) Mechanism of substrate translocation in an alternating access transporter. Cell 169:96–107.e12. https://doi.org/10.1016/j.cell.2017.03.010
Lee Y, Nishizawa T, Yamashita K, Ishitani R, Nureki O (2015) Structural basis for the facilitative diffusion mechanism by SemiSWEET transporter. Nat Commun 6:6112. https://doi.org/10.1038/ncomms7112
Li T, Liu B, Spalding MH, Weeks DP, Yang B (2012) High-efficiency TALEN-based gene editing produces disease-resistant rice. Nat Biotechnol 30:390–392. https://doi.org/10.1038/nbt.2199
Lin IW, Sosso D, Chen L-Q, Gase K, Kim S-G, Kessler D, Klinkenberg PM, Gorder MK, Hou B-H, Qu X-Q, Carter CJ, Baldwin IT, Frommer WB (2014) Nectar secretion requires sucrose phosphate synthases and the sugar transporter SWEET9. Nature 508:546–549. https://doi.org/10.1038/nature13082
Sosso D, Luo D, Li Q-B, Sasse J, Yang J, Gendrot G, Suzuki M, Koch KE, McCarty DR, Chourey PS, Rogowsky PM, Ross-Ibarra J, Yang B, Frommer WB (2015) Seed filling in domesticated maize and rice depends on SWEET-mediated hexose transport. Nat Genet 47:1489–1493. https://doi.org/10.1038/ng.3422
Tao Y, Cheung LS, Li S, Eom J-S, Chen L-Q, Xu Y, Perry K, Frommer WB, Feng L (2015) Structure of a eukaryotic SWEET transporter in a homotrimeric complex. Nature 527:259–263. https://doi.org/10.1038/nature15391
Wang J, Yan C, Li Y, Hirata K, Yamamoto M, Yan N, Hu Q (2014) Crystal structure of a bacterial homologue of SWEET transporters. Cell Res 24:1486–1489. https://doi.org/10.1038/cr.2014.144
Xu Y, Tao Y, Cheung LS, Fan C, Chen L-Q, Xu S, Perry K, Frommer WB, Feng L (2014) Structures of bacterial homologues of SWEET transporters in two distinct conformations. Nature 515:448–452. https://doi.org/10.1038/nature13670
Zhou J, Peng Z, Long J, Sosso D, Liu B, Eom J-S, Huang S, Liu S, Vera Cruz C, Frommer WB, White FF, Yang B (2015) Gene targeting by the TAL effector PthXo2 reveals cryptic resistance gene for bacterial blight of rice. Plant J Cell Mol Biol 82:632–643. https://doi.org/10.1111/tpj.12838
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Section Editor information
Rights and permissions
Copyright information
© 2018 European Biophysical Societies' Association (EBSA)
About this entry
Cite this entry
Sosso, D., Chen, LQ., Frommer, W.B. (2018). SemiSWEET-SWEET Glucoside Transporter Superfamily (SLC50). In: Roberts, G., Watts, A. (eds) Encyclopedia of Biophysics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35943-9_685-1
Download citation
DOI: https://doi.org/10.1007/978-3-642-35943-9_685-1
Received:
Accepted:
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-35943-9
Online ISBN: 978-3-642-35943-9
eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences