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Bleeding Disorders

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Textbook of Clinical Pediatrics

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Familial bleeding disorders affecting males have been described in religious and historical texts for thousands of years. Hemophilia A (classic hemophilia) and B (Christmas Disease) are clinically indistinguishable and discussed together in this chapter. Some of most famous individuals affected with hemophilia have been the descendents of Queen Victoria of England and the Empress of the Indies, including Czar Alexis. The downfall of the Russian aristocracy is partially attributed to the poor health of Czar Alexis and the royal family’s dependence upon their physician, Rasputin, for advice. Analysis of Czar Alexis’ DNA revealed a substitution in exon 4 of the factor IX gene. Schonlein termed the disease hemophilia in the 1820s. In the early twentieth century, experiments by several investigators determined that the plasma and, more specifically, the “globulin fraction” of blood plasma could correct the clotting defect of the blood of affected patients in vivo and in vitro, leading to...

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Authors and Affiliations

  1. Department of Pediatrics, Primary Children Hospital, University of Utah, 100 N. Mario Capecchi Dr, Salt Lake City, UT, 84113, USA

    Hassan M. Yaish M.D. (Professor)

  2. St. Luke’s Mountain States Tumor and Medical Research Institute, Boise, ID, USA

    Dr. Eugenia Chang

Authors
  1. Hassan M. Yaish M.D.
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  2. Dr. Eugenia Chang
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Correspondence to Hassan M. Yaish M.D. .

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Editors and Affiliations

  1. Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia

    Abdelaziz Y. Elzouki (Professor of Pediatrics) (Professor of Pediatrics)

  2. National Center of Allergy, Asthma & Immunology (NCAAI), Riyadh, Saudi Arabia

    Harb A. Harfi (Director) (Director)

  3. Consultant Pediatric Gastroenterology & Hepatology, Islamic Hospital, Amman, Jordan

    Hisham M. Nazer

  4. Seattle Children's Hospital University of Washington, School of Medicine, Seattle, WA, USA

    F. Bruder Stapleton (Professor and Chair Department of Pediatrics) (Professor and Chair Department of Pediatrics)

  5. Alpert Medical School of Brown University, Woman and Infants Hospital, Providence, RI, USA

    William Oh (Professor of Pediatrics) (Professor of Pediatrics)

  6. University of Alabama, Birmingham, AL, USA

    Richard J. Whitley (Professor of Pediatrics) (Professor of Pediatrics)

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Yaish, H.M., Chang, E. (2012). Bleeding Disorders. In: Elzouki, A.Y., Harfi, H.A., Nazer, H.M., Stapleton, F.B., Oh, W., Whitley, R.J. (eds) Textbook of Clinical Pediatrics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02202-9_335

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  • DOI: https://doi.org/10.1007/978-3-642-02202-9_335

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