Synonyms
Structural vascular stabilization; Functional vascular stabilization; Vascular maturation; Vascular remodeling
Definition
Vascular stabilization stands for the basic steps of the morphogenetic processes, finally leading to vascular maturation such as establishment of inter-endothelial contacts, development of a regularly structured basement membrane envelo** both endothelial cells and pericytes, and integration of one layer of peri-endothelial cells (pericytes or smooth muscle cells) into the vascular wall.
Characteristics
Normal Vascular Hierarchy
The adult vascular system is hierarchically organized in large, middle sized, and micro vessels at both the arterial and venous sides. The lumen of all blood vessels is lined by endothelial cells (EC). EC are of mesodermal/mesenchymal origin and differentiate from hemangioblasts; they are probably the common precursor of endothelial and hematopoietic cells. The first hemangioblasts are visible in the blood islands of...
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References
Bazzoni G, Dejana E (2004) Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev 84:869–901
Ergun S, Tilki D, Oliveira-Ferrer L et al (2005) Significance of vascular stabilization for tumor growth and metastasis. Cancer Lett 18:180–187
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Thurston G, Rudge JS, Ioffe E et al. (2000) Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med 6:460–463
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© 2008 Springer-Verlag Berlin Heidelberg New York
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Ergün, S., Tilki, D., Kilic, N. (2008). Vascular Stabilization. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-47648-1_6160
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DOI: https://doi.org/10.1007/978-3-540-47648-1_6160
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-36847-2
Online ISBN: 978-3-540-47648-1
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