Veterinary Antibiotics in Animal Diet: Effects on Waste/Environment

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Bioactive Molecules in Food

Abstract

Residues of veterinary antibiotics in the environment pose a risk for aquatic and terrestrial ecosystems. The degradation of antibiotics in the environment has not been fully characterized in spite of the long periods of persistence of residues in the environment. This chapter reviews the main antibiotics found in water bodies and on land as well as its effects on microbial communities, along with some strategies that have been proposed by global organizations to control the use of antibiotics in the livestock production industry.

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References

  1. FAO. Antimicrobial resistance in food and agriculture. (2017). Available from: http://www.fao.org/antimicrobial-resistance

  2. Kümmerer K (2003) Significance of antibiotics in the environment. J Antimicrob Chemother 52:5–7. https://doi.org/10.1093/jac/dkg293

    Article  CAS  PubMed  Google Scholar 

  3. Kümmerer K (2009) Antibiotics in the aquatic environment – a review – part I. Chemosphere 75:417–434. https://doi.org/10.1016/j.chemosphere.2008.11.086

    Article  CAS  PubMed  Google Scholar 

  4. Food and Drug Administration, FDA (2012) The Green Book – FDA approved products. Food and Drug Administration, Rockville. Available from: http://www.accessdata.fda.gov/scripts/animaldrugsatfda

    Google Scholar 

  5. Kim KR, Owens G, Kwon SI, So KH, Lee DB, Ok YS (2011) Occurrence and environmental fate of veterinary antibiotics in the terrestrial environment. Water Air Soil Pollut 214:163–174. https://doi.org/10.1007/s11270-010-0412-2

    Article  CAS  Google Scholar 

  6. Van Boeckel TP, Brower C, Gilbert M, Grenfell BT, Levin SA, Robinson TP, Laxminarayan R (2015) Global trends in antimicrobial use in food animals. Proc Natl Acad Sci U S A 112(18):5649–5654. https://doi.org/10.1073/pnas.1503141112

    Article  CAS  PubMed  Google Scholar 

  7. Li C, Chen J, Wang J, Ma Z, Han P, Luan Y, Lu A (2015) Occurrence of antibiotics in soils and manures from greenhouse vegetable production bases of Bei**g, China and an associated risk assessment. Sci Total Environ 521:101–107. https://doi.org/10.1016/j.scitotenv.2015.03.070

    Article  CAS  PubMed  Google Scholar 

  8. Solliec M, Roy-Lachapelle A, Gasser MO, Coté C, Genéreux M, Sauvé S (2016) Fractionation and analysis of veterinary antibiotics and their related degradation products in agricultural soils and drainage waters following swine manure amendment. Sci Total Environ 543:524–535. https://doi.org/10.1016/j.scitotenv.2015.11.061

    Article  CAS  PubMed  Google Scholar 

  9. Zuccato E, Castiglioni S, Bagnati R, Melis M, Fanelli R (2010) Source, occurrence and fate of antibiotics in the Italian aquatic environment. J Hazard Mater 179:1042–1048. https://doi.org/10.1016/j.jhazmat.2010.03.110

    Article  CAS  PubMed  Google Scholar 

  10. Cardoso O, Porcher JM, Sanchez W (2014) Factory-discharged pharmaceuticals could be a relevant source of aquatic environment contamination: review of evidence and need for knowledge. Chemosphere 115:20–30. https://doi.org/10.1016/j.chemosphere.2014.02.004

    Article  CAS  PubMed  Google Scholar 

  11. Review on Antimicrobial Resistance (2014) Antimicrobial resistance: tackling a crisis for the health and wealth of nations. Review on Antimicrobial Resistance, London. Available from: https://amr-review.org

    Google Scholar 

  12. Bengtsson-Palme J, Larsson DGJ (2016) Concentrations of antibiotics predicted to select for resistant bacteria: proposed limits for environmental regulation. Environ Int 86:140–149. https://doi.org/10.1016/j.envint.2015.10.015

    Article  CAS  PubMed  Google Scholar 

  13. Tello A, Austin B, Telfer TC (2012) Selective pressure of antibiotic pollution on bacteria of importance to public health. Environ Health Perspect 120:1100–1106. https://doi.org/10.1289/ehp.1104650

    Article  PubMed  Google Scholar 

  14. Dang B, Mao D, Xu Y, Luo Y (2017) Conjugative multi-resistant plasmids in Haihe River and their impacts on the abundance and spatial distribution of antibiotic resistance genes. Water Res 111:81–91. https://doi.org/10.1016/j.watres.2016.12.046

    Article  CAS  PubMed  Google Scholar 

  15. Kemper N (2008) Veterinary antibiotics in the aquatic and terrestrial environment. Ecol Indic 8(1):1–13. https://doi.org/10.1016/j.ecolind.2007.06.002

    Article  CAS  Google Scholar 

  16. Chen YS, Zhang HB, Luo YM, Song J (2012) Occurrence and dissipation of veterinary antibiotics in two typical swine wastewater treatment systems in East China. Environ Monit Assess 184:2205–2217. https://doi.org/10.1007/s10661-011-2110-y

    Article  CAS  PubMed  Google Scholar 

  17. Tasho RP, Cho JY (2016) Veterinary antibiotics in animal waste, its distribution in soil and uptake by plants: a review. Sci Total Environ 563–564:366–376. https://doi.org/10.1016/j.scitotenv.2016.04.140

    Article  CAS  PubMed  Google Scholar 

  18. Alexandrino DAM, Mucha AP, Almeida CMR, Gao W, Jia Z, Carvalho MF (2017) Biodegradation of the veterinary antibiotics enrofloxacin and ceftiofur and associated microbial community dynamics. Sci Total Environ 581–582:359–368. https://doi.org/10.1016/j.scitotenv.2016.12.141

    Article  CAS  PubMed  Google Scholar 

  19. Heuer H, Focks A, Lamshöft M, Smalla K, Matthies M, Spiteller M (2008) Fate of sulfadiazine administered to pigs and its quantitative effect on the dynamics of bacterial resistance genes in manure and manured soil. Soil Biol Biochem 40(7):1892–1900. https://doi.org/10.1016/j.soilbio.2008.03.014

    Article  CAS  Google Scholar 

  20. Jechelke S, Heuer H, Siemens J, Amelung W, Smalla K (2014) Fate and effects of veterinary antibiotics in soil. Trends Microbiol 22(9):536–545. https://doi.org/10.1016/j.tim.2014.05.005

    Article  CAS  Google Scholar 

  21. Dalkmann P, Broszat M, Siebe C, Willaschek E, Sakinc T, Huebner J, Amelung W, Grohmann E, Siemens J (2012) Accumulation of pharmaceuticals, enterococcus, and resistance genes in soils irrigated with wastewater for zero to 100 years in Central Mexico. PLoS One 7:e45397. https://doi.org/10.1371/journal.pone.0045397

    Article  CAS  PubMed  Google Scholar 

  22. Tuan XL, Munekage Y (2004) Residues of selected antibiotics in water and mud from shrimp ponds in mangrove areas in Vietnam. Mar Pollut Bull 49:922–929. PMID: 15556177

    Article  Google Scholar 

  23. Zhao L, Dong YH, Wang H (2010) Residues of veterinary antibiotics in manures from feedlot livestock in eight provinces of China. Sci Total Environ 408:1069–1075. https://doi.org/10.1016/j.scitotenv.2009.11.014

    Article  CAS  PubMed  Google Scholar 

  24. Hu X, Zhou Q, Luo Y (2010) Occurrence and source analysis of typical veterinary antibiotics in manure, soil, vegetables and groundwater from organic vegetable bases, northern China. Environ Pollut 158:2992–2998. https://doi.org/10.1016/j.envpol.2010.05.023

    Article  CAS  PubMed  Google Scholar 

  25. Martínez-Carballo E, González-Barreiro C, Scharf S, Gans O (2009) Environmental monitoring study of selected veterinary antibiotics in animal manure and soils in Austria. Environ Pollut 148:570–579. https://doi.org/10.1016/j.envpol.2006.11.035

    Article  CAS  Google Scholar 

  26. Shi Y, Gao L, Li W, Liu J, Cai Y (2012) Investigation of fluoroquinolones, sulfonamides and macrolides in long-term wastewater irrigation soil in Tian**. China Bull Environ Contam Toxicol 89:857–861. https://doi.org/10.1007/s00128-012-0761-1

    Article  CAS  PubMed  Google Scholar 

  27. Hou J, Wan W, Mao D, Wang C, Mu Q, Qui S, Luo Y (2015) Occurrence and distribution of sulfonamides, tetracyclines, quinolones, macrolides, and nitrofurans in livestock manure and amended soils of northern China. Environ Sci Pollut Res 22:4545–4554. https://doi.org/10.1007/s11356-014-3632-y

    Article  CAS  Google Scholar 

  28. Ma Y, Chen ZL (2007) Measurement of enrofloxacin remained in hog farms and their circumference. J Tradit Chinese Vet Med 6:11–16

    Google Scholar 

  29. Christian T, Schneider RJ, Färber HA, Skutlarek D, Meyer MT, Goldbach HE (2003) Determination of antibiotic residues in manure, soil, and surface waters. Acta Hydrochim Hydrobiol 31:36–44. https://doi.org/10.1002/aheh.200390014

    Article  CAS  Google Scholar 

  30. Pan X, Qiang ZM, Ben WW, Chen MX (2011) Residual veterinary antibiotics in swine manure from concentrated animal feeding operations in Shandong Province, China. Chemosphere 84:695–700. https://doi.org/10.1016/j.chemosphere.2011.03.022

    Article  CAS  PubMed  Google Scholar 

  31. Hamscher G, Sczesny S, Hoper H, Nau H (2002) Determination of persistent tetracycline residues in soil fertilized with liquid manure by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. Anal Chem 74:1509–1518. https://doi.org/10.1021/ac015588m

    Article  CAS  PubMed  Google Scholar 

  32. Awad YM, Kim SC, EI-Azeem SAMA, Kim KH, Kim KR, Kim KJ, Jeon C, Lee SS, Ok YS (2014) Veterinary antibiotics contamination in water, sediment, and soil near a swine manure composting facility. Environ Earth Sci 71:1433–1440. https://doi.org/10.1007/s12665-013-2548-z

    Article  CAS  Google Scholar 

  33. Lin D, Zhou Q, Xu Y, Chen C, Li Y (2012) Physiological and molecular responses of the earthworm (Eisenia fetida) to soil chlortetracycline contamination. Environ Pollut 171:46–51. https://doi.org/10.1016/j.envpol.2012.07.020

    Article  CAS  PubMed  Google Scholar 

  34. **e X, Zhou Q, Lin D, Guo J, Bao Y (2010) Toxic effect of tetracycline exposure on growth, antioxidative and genetic indices of wheat (Triticum aestivum L.). Environ Sci Pollut Res 18(4):566–575. https://doi.org/10.1007/s11356-010-0398-8

    Article  CAS  Google Scholar 

  35. Tang X, Lou C, Wang S, Lu Y, Liu M, Hashmi MZ, Liang X, Li Z, Liao Y, Qin W, Fan F, Xu J, Brookes PC (2015) Effects of long-term manure applications on the occurrence of antibiotics and antibiotic resistance genes (ARGs) in paddy soils: Evidence from four field experiments in south of China. Soil Biol Biochem 90:179–187. https://doi.org/10.1016/j.soilbio.2015.07.027

    Article  CAS  Google Scholar 

  36. Boxall ABA, Johnson P, Smith EJ, Sinclair CJ, Stutt E, Levy LS (2006) Uptake of veterinary medicines from soils into plants. J Agric Food Chem 54:2288–2297

    Article  CAS  PubMed  Google Scholar 

  37. Zhang H, Zhou Y, Huang Y, Wu L, Liu X, Luo Y (2016) Residues and risks of veterinary antibiotics in protected vegetable soils following application of different manures. Chemosphere 152:229–237. https://doi.org/10.1021/jf053041t

    Article  CAS  PubMed  Google Scholar 

  38. De Liguoro M, Cibin V, Capolongo F, Halling-Sørensen B, Montesissa C (2003) Use of oxytetracycline and tylosin in intensive calf farming: evaluation of transfer to manure and soil. Chemosphere 52:203–212. https://doi.org/10.1016/S0045-6535(03)00284-4

    Article  CAS  PubMed  Google Scholar 

  39. Knapp CW, Dolfing J, Ehlert PAI, Graham DW (2010) Evidence of increasing antibiotic resistance gene abundances in archived soils since 1940. Environ Sci Technol 44:580–587. https://doi.org/10.1021/es901221x

    Article  CAS  PubMed  Google Scholar 

  40. Ogle M (2013) In meat we trust: an unexpected history of carnivore America. Houghton Mifflin Harcourt, Boton. ISBN 978-0151013401

    Google Scholar 

  41. Von Nussbaum F, Brands M, Hinzen B (2006) Medicinal chemistry of antibacterial natural products exodus or revival? Angew Chem Int Ed 45:5072–5129. https://doi.org/10.1002/anie.200600350

    Article  CAS  Google Scholar 

  42. Zhang QQ, Ying GG, Pan CG, Liu YS, Zhao JL (2015) Comprehensive evaluation of antibiotics emission and fate in the river basins of China: source analysis, multimedia modeling, and linkage to bacterial resistance. Environ Sci Technol 49:6772–6782. https://doi.org/10.1021/acs.est.5b00729

    Article  CAS  PubMed  Google Scholar 

  43. Wang FH, Ma WQ, Dou ZX, Ma L, Liu XL, Xu JX, Zhang FS (2006) The estimation of the production amount of animal manure and its environmental effect in China. China Environ Sci 26:614–617. https://doi.org/10.3321/j.issn:1000-6923.2006.05.024

    Article  Google Scholar 

  44. Välitalo P, Kruglova A, Mikola A, Vahala R (2017) Toxicological impacts of antibiotics on aquatic micro-organisms: a mini-review. Int J Hyg Environ Health 220(3):558–569. https://doi.org/10.1016/j.ijheh.2017.02.003

    Article  CAS  PubMed  Google Scholar 

  45. Mitchell SM, Ullman JL, Teel AL, Watts RJ (2014) pH and temperature effects on the hydrolysis of three β-lactam antibiotics: ampicillin, cefalotin and cefoxitin. Sci Total Environ 466:547–555. https://doi.org/10.1016/j.scitotenv.2013.06.027

    Article  CAS  PubMed  Google Scholar 

  46. Lin JS, Pan HY, Liu SM, Lai HT (2010) Effects of light and microbial activity on the degradation of two fluoroquinolone antibiotics in pond water and sediment. J Environ Sci Health B 45:456–465. https://doi.org/10.1080/03601231003800222

    Article  CAS  PubMed  Google Scholar 

  47. Lamshöft M, Sukul P, Zühlke S, Spiteller M (2010) Behaviour of 14C-sulfadiazine and 14C-difloxacin during manure storage. Sci Total Environ 408:1563–1568. https://doi.org/10.1016/j.scitotenv.2009.12.010

    Article  CAS  PubMed  Google Scholar 

  48. Ramaswamy J, Prasher SO, Patel RM, Hussain SA, Barrington SF (2010) The effect of composting on the degradation of a veterinary pharmaceutical. Bioresour Technol 101(7):2294–2299. https://doi.org/10.1016/j.biortech.2009.10.089

    Article  CAS  PubMed  Google Scholar 

  49. Walters E, McClellan K, Halden RU (2010) Occurrence and loss over three years of 72 pharmaceuticals and personal care products from biosolids–soil mixtures in outdoor mesocosms. Water Res 44:6011–6020. https://doi.org/10.1016/j.watres.2010.07.051

    Article  CAS  PubMed  Google Scholar 

  50. Zarfl C, Klasmeier J, Matthies M (2009) A conceptual model describing the fate of sulfadiazine and its metabolites observed in manure-amended soils. Chemosphere 77:720–726. https://doi.org/10.1016/j.chemosphere.2009.08.035

    Article  CAS  PubMed  Google Scholar 

  51. Pruden A, Arabi M, Storteboom HN (2012) Correlation of upstream human activities with riverine antibiotic resistance genes. Environ Sci Technol 46:11541–11549. https://doi.org/10.1021/es302657r

    Article  CAS  PubMed  Google Scholar 

  52. Aydin S, Ince B, Ince O (2016) Assessment of anaerobic bacterial diversity and its effects on anaerobic system stability and the occurrence of antibiotic resistance genes. Bioresour Technol 207:332–338. https://doi.org/10.1016/j.biortech.2016.01.080

    Article  CAS  PubMed  Google Scholar 

  53. Liu B, Li Y, Zhang X, Wang J, Gao M (2015) Effects of chlortetracycline on soil microbial communities: comparisons of enzyme activities to the functional diversity via biolog EcoPlates™. Eur J Soil Biol 68:69–76. https://doi.org/10.1016/j.ejsobi.2015.01.002

    Article  CAS  Google Scholar 

  54. Yan C, Dinh QT, Chevreuil M, Garnier J, Roose-Amsaleg C, Labadie P, Laverman AM (2013) The effect of environmental and therapeutic concentrations of antibiotics on nitrate reduction rates in river sediment. Water Res 47:3654–3662

    Article  CAS  PubMed  Google Scholar 

  55. Pan M, Chu LM (2015) Adsorption and degradation of five selected antibiotics in agricultural soil. Sci Total Environ 545–546:48–56. https://doi.org/10.1016/j.watres.2013.04.025

    Article  CAS  PubMed  Google Scholar 

  56. Sun M, Ye M, Liu K, Schwab AP, Liu M, Jiao J, Feng Y, Wan J, Tian D, Wu J, Hu F, Jiang X (2017) Dynamic interplay between microbial denitrification and antibiotic resistance under enhanced anoxic denitrification condition in soil. Environ Pollut 222:583–591. https://doi.org/10.1016/j.envpol.2016.10.015

    Article  CAS  PubMed  Google Scholar 

  57. Oszaki N, Bester K, Møldruo P, Henriksen K, Komatsu T (2011) Photodegradation of the synthetic fragrance OTNE and the bactericide triclosan adsorbed on dried loamy sand – results from models and experiments. Chemosphere 83:1475–1479. https://doi.org/10.1016/j.chemosphere.2011.03.006

    Article  CAS  Google Scholar 

  58. Joy SR, Bartelt-Hunt SL, Snow DD, Gilley JE, Woodbury BL, Parker DB, Marx DB, Li X (2013) Fate and transport of antimicrobials and antimicrobial resistance genes in soil and runoff following land application of swine manure slurry. Environ Sci Technol 47:12081–12088. https://doi.org/10.1021/es4026358

    Article  CAS  PubMed  Google Scholar 

  59. Popova IE, Bair DA, Tate KW, Parikh SJ (2013) Sorption, leaching, and surface runoff of beef cattle veterinary pharmaceuticals under simulated irrigated pasture conditions. J Environ Qual 42:1167–1175. https://doi.org/10.2134/jeq2013.01.0012

    Article  CAS  PubMed  Google Scholar 

  60. Blackwell PA, Kay P, Ashauer R, Boxall ABA (2009) Effects of agricultural conditions on the leaching behaviour of veterinary antibiotics in soils. Chemosphere 75:13–19. https://doi.org/10.1016/j.chemosphere.2008.11.070

    Article  CAS  PubMed  Google Scholar 

  61. Ostermann A, Siemens J, Welp G, Xue Q, Lin X, Liu X, Amelung W (2013) Leaching of veterinary antibiotics in calcareous Chinese croplands. Chemosphere 91:928–934. https://doi.org/10.1016/j.chemosphere.2013.01.110

    Article  CAS  PubMed  Google Scholar 

  62. Kumar K, Gupta SC, Baidoo SK, Chander Y, Rosen CJ (2005) Antibiotic uptake by plants from soil fertilized with animal manure. J Environ Qual 34:2082–2085. https://doi.org/10.2134/jeq2005.0026

    Article  CAS  PubMed  Google Scholar 

  63. Grote M, Schwake-Anduschus C, Michel R, Stevens H, Heyser W, Langenkämper G, Betsche T, Freitag M (2007) Incorporation of veterinary antibiotics into crops from manured soil. Landbauforschung Völkenrode FAL Agric Res 57(1):25–32

    CAS  Google Scholar 

  64. Rosendahl I, Siemens J, Groeneweg J, Linzbach E, Laabs V, Herrmann C, Vereecken H, Amelung W (2011) Dissipation and sequestration of the veterinary antibiotic sulfadiazine and its metabolites under field conditions. Environ Sci Technol 45:5216–5222. https://doi.org/10.1021/es200326t

    Article  CAS  PubMed  Google Scholar 

  65. Rosendahl I, Siemens J, Kindler R, Groeneweg J, Zimmermann J, Czerwinski S, Lamshöft M, Laabs V, Wilke BM, Vereecken H, Amelung W (2012) Persistence of the fluoroquinolone antibiotic difloxacin in soil and lacking effects on nitrogen turnover. J Environ Qual 41:1275–1283. https://doi.org/10.2134/jeq2011.0459

    Article  CAS  PubMed  Google Scholar 

  66. Migliore L, Rotini A, Cerioli NL, Cozzolino S, Fiori M (2010) Phytotoxic sulfadimethoxine elicits a complex hormetic response in the weed Lythrum salicaria L. Dose-Response 8(4):414–427. https://doi.org/10.2203/dose-response.09-033.Migliore

    Article  CAS  PubMed  Google Scholar 

  67. Migliore L, Civitareale C, Brambilla G, Cozzolino S, Casoria P, Gaudio L (1997) Effect of sulphadimethoxine on cosmopolitan weeds (Amaranthus retroflexus L., Plantago major L., and Rumex acetosella L.). Agric Ecosyst Environ 65:163–168. https://doi.org/10.1016/S0167-8809(97)00062-5

    Article  CAS  Google Scholar 

  68. Wang J, Lin H, Sun W, **a Y, Ma J, Fu J, Zhang Z, Wu H, Qian M (2016) Variations in the fate and biological effects of sulfamethoxazole, norfloxacin and doxycycline in different vegetable-soil systems following manure application. J Hazard Mater 304:49–57. https://doi.org/10.1016/j.jhazmat.2015.10.038

    Article  CAS  PubMed  Google Scholar 

  69. Johnson AC, Keller V, Dumont E, Sumpter JP (2015) Assessing the concentrations and risks of toxicity from the antibiotics ciprofloxacin, sulfamethoxazole, trimethoprim and erythromycin in European rivers. Sci Total Environ 1(511):747–755. https://doi.org/10.1016/j.scitotenv.2014.12.055

    Article  CAS  Google Scholar 

  70. Venkatesan AK, Halden RU (2014) Wastewater treatment plants as chemical observatories to forecast ecological and human health risks of manmade chemicals. Sci Rep 4:37–31. https://doi.org/10.1038/srep03731

    Article  CAS  Google Scholar 

  71. Zhang R, Tang J, Li J, Cheng Z, Chaemfa C, Liu D, Zheng Q, Song M, Luo C, Zhang G (2013) Occurrence and risks of antibiotics in the coastal aquatic environment of the yellow sea, North China. Sci Total Environ 450-451:197–204. https://doi.org/10.1016/j.scitotenv.2013.02.024

    Article  CAS  PubMed  Google Scholar 

  72. Verlicchi P, Al Aukidy M, Zambello E (2012) Occurrence of pharmaceutical compounds in urban wastewater: Removal, mass load and environmental risk after a secondary treatment – a review. Sci Total Environ 429:123–155. https://doi.org/10.1016/j.scitotenv.2012.04.028

    Article  CAS  PubMed  Google Scholar 

  73. Berman-Frank I, Lundgren P, Falkowski P (2003) Nitrogen fixation and photosynthetic oxygen evolution in cyanobacteria. Res Microbiol 154(3):157–164. https://doi.org/10.1016/S0923-2508(03)00029-9

    Article  CAS  PubMed  Google Scholar 

  74. Brandt KK, Amézquita A, Backhaus T, Boxall A, Coors A, Heberer T, Lawrence JR, Lazorchak J, Schönfeld J, Snape JR, Zhu YG, Topp E (2015) Ecotoxicological assessment of antibiotics: a call for improved consideration of microorganisms. Environ Int 85:189–205. https://doi.org/10.1016/j.envint.2015.09.013

    Article  CAS  PubMed  Google Scholar 

  75. Guo J, Selby K, Boxall AB (2016) Effects of antibiotics on the growth and physiology of chlorophytes, cyanobacteria, and a diatom. Arch Environ Contam Toxicol 71:589–602. https://doi.org/10.1007/s00244-016-0305-5

    Article  CAS  PubMed  Google Scholar 

  76. Carvalho IT, Santos L (2016) Antibiotics in the aquatic environments: a review of the European scenario. Environ Int 94:736–757. https://doi.org/10.1016/j.envint.2016.06.025

    Article  PubMed  Google Scholar 

  77. Gonzalez-Pleiter M, Gonzalo S, Rodea-Palomares I, Leganes F, Rosal R, Boltes K, Marco E, Fernandez-Piñas F (2013) Toxicity of five antibiotics and their mixtures towards photosynthetic aquatic organisms: implications for environmental risk assessment. Water Res 47:2050–2064. https://doi.org/10.1016/j.watres.2013.01.020

    Article  CAS  PubMed  Google Scholar 

  78. Directive 2008/105/EC (2008) Environmental quality standards in the field of water policy, amending and subsequently repealing Council Directives 82/176/EEC, 83/513/EEC, 84/156/EEC, 84/491/EEC, 86/280/EEC and Amending Directive 2000/60/EC. Off J Eur Union L 348: 84–97

    Google Scholar 

  79. Grenni P, Ancona V, Anna Barra AC (2017) Ecological effects of antibiotics on natural ecosystems: A review. Microchem J 136:25–39. https://doi.org/10.1016/j.microc.2017.02.006

    Article  CAS  Google Scholar 

  80. Wei R, Ge F, Chen M, Wang R (2012) Occurrence of ciprofloxacin, enrofloxacin, and florfenicol in animal wastewater and water resources. J Environ Qual 41(5):1481–1486. https://doi.org/10.2134/jeq2012.0014

    Article  CAS  PubMed  Google Scholar 

  81. Watkinson AJ, Murby EJ, Kolpin DW, Costanzo SD (2009) The occurrence of antibiotics in an urban watershed: from wastewater to drinking water. Sci Total Environ 407:2711–2723. https://doi.org/10.1016/j.scitotenv.2008.11.059

    Article  CAS  PubMed  Google Scholar 

  82. Leung HW, Minh TB, Murphy MB, Lam JC, So MK, Martin M, Lam KSP, Richardson BJ (2012) Distribution, fate and risk assessment of antibiotics in sewage treatment plants in Hong Kong, South China. Environ Int 42:1–9. https://doi.org/10.1016/j.envint.2011.03.004

    Article  CAS  PubMed  Google Scholar 

  83. Dinh QT, Alliot F, Moreau-Guigon E, Eurin J, Chevreuil M, Labadie P (2011) Measurement of trace levels of antibiotics in river water using on-line enrichment and triple-quadrupole LC–MS/MS. Talanta 85(3):1238–1245. https://doi.org/10.1016/j.talanta.2011.05.013

    Article  CAS  PubMed  Google Scholar 

  84. Alygizakis NA, Gago-Ferrero P, Borova VL, Pavlidou A, Hatzianestis I, Thomaidis NS (2016) Occurrence and spatial distribution of 158 pharmaceuticals, drugs of abuse and related metabolites in offshore seawater. Sci Total Environ 541:1097–1105. https://doi.org/10.1016/j.scitotenv.2015.09.145

    Article  CAS  PubMed  Google Scholar 

  85. Giang CND, Sebesvari Z, Renaud F, Rosendahl I, Minh QH, Amelung W (2015) Occurrence and dissipation of the antibiotics sulfamethoxazole, sulfadiazine, trimethoprim, and Enrofloxacin in the Mekong Delta. Vietnam PloS one 10(7):e0131855. https://doi.org/10.1371/journal.pone.0131855

    Article  CAS  Google Scholar 

  86. Gao L, Shi Y, Li W, Niu H, Liu J, Cai Y (2012) Occurrence of antibiotics in eight sewage treatment plants in Bei**g. China Chemosphere 86(6):665–671. https://doi.org/10.1016/j.chemosphere.2011.11.019

    Article  CAS  PubMed  Google Scholar 

  87. Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ (2009) The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters. Water Res 43:363–380. https://doi.org/10.1016/j.watres.2008.10.047

    Article  CAS  PubMed  Google Scholar 

  88. Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ (2008) The occurrence of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs in surface water in South Wales, UK. Water Res 42:3498–3518. https://doi.org/10.1016/j.watres.2008.04.026

    Article  CAS  PubMed  Google Scholar 

  89. Barnes KK, Kolpin DW, Furlong ET, Zaugg SD, Meyer MT, Barber LB (2008) A national reconnaissance of pharmaceuticals and other organic wastewater contaminants in the United States – (I) groundwater. Sci Total Environ 402(2):192–200. https://doi.org/10.1016/j.scitotenv.2008.04.028

    Article  CAS  PubMed  Google Scholar 

  90. Bartelt-Hunt SL, Snow DD, Damon T, Shockley J, Hoagland K (2009) The occurrence of illicit and therapeutic pharmaceuticals in wastewater effluent and surface waters in Nebraska. Environ Pollut 157(3):786–791. https://doi.org/10.1016/j.envpol.2008.11.025

    Article  CAS  PubMed  Google Scholar 

  91. Dong H, Yuan X, Wang W, Qiang Z (2016) Occurrence and removal of antibiotics in ecological and conventional wastewater treatment processes: a field study. J Environ Manag 178:11–19. https://doi.org/10.1016/j.jenvman.2016.04.037

    Article  CAS  Google Scholar 

  92. Pailler JY, Krein A, Pfister L, Hoffmann L, Guignard C (2009) Solid phase extraction coupled to liquid chromatography-tandem mass spectrometry analysis of sulfonamides, tetracyclines, analgesics and hormones in surface water and wastewater in Luxembourg. Sci Total Environ 407(16):4736–4743. https://doi.org/10.1016/j.scitotenv.2009.04.042

    Article  CAS  PubMed  Google Scholar 

  93. Yang S, Carlson K (2003) Evolution of antibiotic occurrence in a river through pristine, urban and agricultural landscapes. Water Res 37:4645–4656. https://doi.org/10.1016/S0043-1354(03)00399-3

    Article  CAS  PubMed  Google Scholar 

  94. Ngumba E, Gachanja A, Tuhkanen T (2016) Occurrence of selected antibiotics and antiretroviral drugs in Nairobi River basin, Kenya. Sci Total Environ 539:206–213. https://doi.org/10.1016/j.scitotenv.2015.08.139

    Article  CAS  PubMed  Google Scholar 

  95. Wille K, Noppe H, Verheyden K, Bussche JV, De Wulf E, Van Caeter P, Janssen CR, De Brabander HF, Vanhaecke L (2010) Validation and application of an LC-MS/MS method for the simultaneous quantification of 13 pharmaceuticals in seawater. Anal Bioanal Chem 397(5):1797–1808. https://doi.org/10.1007/s00216-010-3702-z

    Article  CAS  PubMed  Google Scholar 

  96. Calamari D, Zuccato E, Castiglioni S, Bagnati R, Fanelli R (2003) Strategic survey of therapeutic drugs in the rivers Po and Lambro in northern Italy. Environ Sci Technol 37:1241–1248. https://doi.org/10.1021/es020158e

    Article  CAS  Google Scholar 

  97. Birošová L, Mackulak T, Bodík I, Ryba J, Škubák J, Grabic R (2014) Pilot study of seasonal occurrence and distribution of antibiotics and drug resistant bacteria in wastewater treatment plants in Slovakia. Sci Total Environ 490:440–444. https://doi.org/10.1016/j.scitotenv.2014.05.030

    Article  CAS  PubMed  Google Scholar 

  98. Rodríguez-Gil JL, Catalá M, Alonso SG, Maroto RR, Valcárcel Y, Segura Y, Molina R, Melero JA, Martínez F (2010) Heterogeneous photo-Fenton treatment for the reduction of pharmaceutical contamination in Madrid rivers and ecotoxicological evaluation by a miniaturized fern spores bioassay. Chemosphere 80(4):381–388. https://doi.org/10.1016/j.chemosphere.2010.04.045

    Article  CAS  PubMed  Google Scholar 

  99. Kimosop SJ, Getenga ZM, Orata F, Okello VA, Cheruiyot JK (2016) Residue levels and discharge loads of antibiotics in wastewater treatment plants (WWTPs), hospital lagoons, and rivers within Lake Victoria Basin. Kenya Environ Monit Assess 188(9):532. https://doi.org/10.1007/s10661-016-5534-6

    Article  CAS  PubMed  Google Scholar 

  100. Magdaleno A, Saenz ME, Juárez AB, Moretton J (2015) Effects of six antibiotics and their binary mixtures on growth of Pseudokirchneriella subcapitata. Ecotoxicol Environ Saf 113:72–78. https://doi.org/10.1016/j.ecoenv.2014.11.021

    Article  CAS  PubMed  Google Scholar 

  101. Long X, Wang D, Lin Z, Qin M, Song C, Liu Y (2016) The mixture toxicity of environmental contaminants containing sulfonamides and other antibiotics in Escherichia coli: differences in both the special target proteins of individual chemicals and their effective combined concentration. Chemosphere 158:193–203. https://doi.org/10.1016/j.chemosphere.2016.05.048

    Article  CAS  PubMed  Google Scholar 

  102. Hao H, Cheng G, Iqbal Z, Ai X, Hussain HI, Huang L, Dai M, Wang Y, Liu Z, Yuan Z (2014) Benefits and risks of antimicrobial use in foodproducing animals. Front Microbiol 5:288. https://doi.org/10.3389/fmicb.2014.00288

    Article  PubMed  Google Scholar 

  103. Economou V, Gousia P (2015) Agriculture and food animals as a source of antimicrobial resistant bacteria. Infect Drug Resist 8:49–61. https://doi.org/10.2147/IDR.S55778

    Article  PubMed  Google Scholar 

  104. Knoblock-Hahn A, Brown K, Medrow L (2016) A balanced approach to understanding the science of antibiotics in animal agriculture. J Acad Nutr Diet 116(8):1332–1335

    Article  PubMed  Google Scholar 

  105. Guillou D (2017) Key issues in designing feed for antibiotic-free pork. Pig Progress. Available from: https://www.pigprogress.net/…/Key-issues-in-designing-feed-for-antibiotic-%20free-pork-117625E/

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Acknowledgments

This study was supported by the Red de Investigación en cambio climático, producción y salud del ganado bovino, and UAEM-CA-193-Ciencia e Innovación Tecnológica Pecuaria. Miss Robles Jimenez and Angeles Hernandez held a grant from the Consejo Nacional de Ciencia y Tecnologia (CONACyT).

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Correspondence to Manuel Gonzalez Ronquillo .

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Robles Jimenez, L.E. et al. (2019). Veterinary Antibiotics in Animal Diet: Effects on Waste/Environment. In: Mérillon, JM., Ramawat, K.G. (eds) Bioactive Molecules in Food. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-78030-6_41

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