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Clinical Immunology in Diagnoses of Maxillofacial Disease

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Contemporary Oral Medicine

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Abstract

There is an immunological basis for a wide spectrum of oral medicine conditions, ranging from autoimmunity to infection. While patient history and physical examination serve as the cornerstones for clinical diagnosis, in many situations additional laboratory testing is necessary in order to arrive at a definitive diagnosis. As such, a comprehensive understanding of clinical immunology and its relevance to the pathogenesis and diagnosis of oral medicine conditions is essential. This chapter provides an overview of the immune system, indications for immunological work-up, a summary of clinical immunology tests relevant to the practice of oral medicine, and a discussion of the oral medicine conditions for which clinical immunological testing may be indicated.

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References

  • Abeles AM, Abeles M. The clinical utility of a positive antinuclear antibody test result. Am J Med. 2013;126(4):342–8.

    Article  PubMed  Google Scholar 

  • Abraham RS. Relevance of antibody testing in patients with recurrent infections. J Allergy Clin Immunol. 2012;130(2):558–9. e6

    Article  PubMed  Google Scholar 

  • Abraham DJ, Krieg T, Distler J, Distler O. Overview of pathogenesis of systemic sclerosis. Rheumatology (Oxford). 2009;48(Suppl 3):iii3–7.

    Google Scholar 

  • Aggarwal A. Role of autoantibody testing. Best Pract Res Clin Rheumatol. 2014;28(6):907–20.

    Article  PubMed  Google Scholar 

  • Agmon-Levin N, Damoiseaux J, Kallenberg C, Sack U, Witte T, Herold M, et al. International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies. Ann Rheum Dis. 2014;73(1):17–23.

    Article  PubMed  Google Scholar 

  • Agostoni A, Aygoren-Pursun E, Binkley KE, Blanch A, Bork K, Bouillet L, et al. Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond. J Allergy Clin Immunol. 2004;114(3 Suppl):S51–131.

    Article  PubMed  PubMed Central  Google Scholar 

  • Al-Hashimi I, Schifter M, Lockhart PB, Wray D, Brennan M, Migliorati CA, et al. Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103(Suppl:S25):e1–12.

    Google Scholar 

  • Ambrose M, Gatti RA. Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions. Blood. 2013;121:4036.

    Article  PubMed  PubMed Central  Google Scholar 

  • American College of Rheumatology Position Statement: Methodology of Testing for Antinuclear Antibodies. https://www.rheumatology.org/Portals/0/Files/Methodology%20of%20Testing%20Antinuclear%20Antibodies%20Position%20Statement.pdf.

  • Anderson NW, Buchan BW, Ledeboer NA. Light microscopy, culture, molecular, and serologic methods for detection of herpes simplex virus. J Clin Microbiol. 2014;52(1):2–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ashley RL. Sorting out the new HSV type specific antibody tests. Sex Transm Infect. 2001;77(4):232–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ausukua M, Dublin I, Echebarria MA, Aguirre JM. Oral allergy syndrome (OAS). General and stomatological aspects. Med Oral Patol Oral Cir Bucal. 2009;14(11):e568–72.

    Article  PubMed  Google Scholar 

  • Aydemir S, Tekin NS, Aktunc E, Numanoglu G, Ustundag Y. Celiac disease in patients having recurrent aphthous stomatitis. Turk J Gastroenterol. 2004;15(3):192–5.

    PubMed  Google Scholar 

  • Baumgart DC, Sandborn WJ. Crohn’s disease. Lancet. 2012;380(9853):1590–605.

    Article  PubMed  Google Scholar 

  • Bhagat M, Sehra ST, Shahane A, Kwan M. Utility of immunologic testing in suspected rheumatologic disease. Curr Allergy Asthma Rep. 2014;14(1):405.

    Article  PubMed  Google Scholar 

  • Bhol KC, Ahmed AR. Production of non-pathogenic human monoclonal antibodies to desmoglein 3 from pemphigus vulgaris patient. Autoimmunity. 2002;35(2):87–91.

    Article  PubMed  Google Scholar 

  • Bonilla FA, Oettgen HC. Adaptive immunity. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S33–40.

    Article  PubMed  Google Scholar 

  • Burnside RD. 22q11.21 deletion syndromes: a review of proximal, central, and distal deletions and their associated features. Cytogenet Genome Res. 2015;146(2):89–99.

    Article  PubMed  Google Scholar 

  • Caprioli F, Marafini I, Facciotti F, Pallone F, Monteleone G. Targeting T cells in chronic inflammatory bowel diseases. J Clin Cell Immunol. 2013;4:1–6.

    Article  Google Scholar 

  • Chan EL, Brandt K, Horsman GB. Comparison of Chemicon SimulFluor direct fluorescent antibody staining with cell culture and shell vial direct immunoperoxidase staining for detection of herpes simplex virus and with cytospin direct immunofluorescence staining for detection of varicella-zoster virus. Clin Diagn Lab Immunol. 2001;8(5):909–12.

    PubMed  PubMed Central  Google Scholar 

  • Cottom H, Mighell AJ, High A, Bateman AC. Are plasma cell-rich inflammatory conditions of the oral mucosa manifestations of IgG4-related disease? J Clin Pathol. 2015;68(10):802–7.

    Article  PubMed  Google Scholar 

  • Cummins DL, Mimouni D, Tzu J, Owens N, Anhalt GJ, Meyerle JH. Lichenoid paraneoplastic pemphigus in the absence of detectable antibodies. J Am Acad Dermatol. 2007;56(1):153–9.

    Article  PubMed  Google Scholar 

  • Dahl H, Marcoccia J, Linde A. Antigen detection: the method of choice in comparison with virus isolation and serology for laboratory diagnosis of herpes zoster in human immunodeficiency virus-infected patients. J Clin Microbiol. 1997;35(2):347–9.

    PubMed  PubMed Central  Google Scholar 

  • Dawes C, Pedersen AM, Villa A, Ekstrom J, Proctor GB, Vissink A, et al. The functions of human saliva: a review sponsored by the World workshop on oral medicine VI. Arch Oral Biol. 2015;60(6):863–74.

    Article  PubMed  Google Scholar 

  • D'Cruz D. Testing for autoimmunity in humans. Toxicol Lett. 2002;127(1–3):93–100.

    Article  PubMed  Google Scholar 

  • De Marie S. Diseases and drug-related interventions affecting host defence. Eur J Clin Microbiol Infect Dis. 1993;12(Suppl 1):S36–41.

    Article  PubMed  Google Scholar 

  • De Rossi SS, Ciarrocca K. Oral lichen planus and lichenoid mucositis. Dent Clin N Am. 2014;58(2):299–313.

    Article  PubMed  Google Scholar 

  • Dreborg S, Foucard T. Allergy to apple, carrot and potato in children with birch pollen allergy. Allergy. 1983;38(3):167–72.

    Article  PubMed  Google Scholar 

  • Dropulic LK, Cohen JI. Severe viral infections and primary immunodeficiencies. Clin Infect Dis. 2011;53(9):897–909.

    Article  PubMed  PubMed Central  Google Scholar 

  • Dunkelberger JR, Song WC. Complement and its role in innate and adaptive immune responses. Cell Res. 2010;20(1):34–50.

    Article  PubMed  Google Scholar 

  • Egan CA, Lazarova Z, Darling TN, Yee C, Yancey KB. Anti-epiligrin cicatricial pemphigoid: clinical findings, immunopathogenesis, and significant associations. Medicine (Baltimore). 2003;82(3):177–86.

    Google Scholar 

  • Elliott K, McQuaid S, Salto-Tellez M, Maxwell P. Immunohistochemistry should undergo robust validation equivalent to that of molecular diagnostics. J Clin Pathol. 2015;68(10):766–70.

    Article  PubMed  Google Scholar 

  • Farkas H, Veszeli N, Kajdacsi E, Cervenak L, Varga L. “Nuts and Bolts” of Laboratory Evaluation of Angioedema. Clin Rev Allergy Immunol. 2016;51:140–51.

    Article  PubMed  Google Scholar 

  • Feller L, Altini M, Khammissa RA, Chandran R, Bouckaert M, Lemmer J. Oral mucosal immunity. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116(5):576–83.

    Article  PubMed  Google Scholar 

  • Ferri C, Bernini L, Cecchetti R, Latorraca A, Marotta G, Pasero G, et al. Cutaneous and serologic subsets of systemic sclerosis. J Rheumatol. 1991;18(12):1826–32.

    PubMed  Google Scholar 

  • Franceschini F, Cavazzana I. Anti-Ro/SSA and La/SSB antibodies. Autoimmunity. 2005;38(1):55–63.

    Article  PubMed  Google Scholar 

  • Franch A, Soriano YJ, Sarrion Perez MG. Dental management of patients with inflammatory bowel disease. J Clin Exp Dent. 2010;2:191–5.

    Article  Google Scholar 

  • Fritz T, Niederreiter L, Adolph T, Blumberg RS, Kaser A. Crohn’s disease: NOD2, autophagy and ER stress converge. Gut. 2011;60(11):1580–8.

    Article  PubMed  Google Scholar 

  • Grutters JC, Fellrath JM, Mulder L, Janssen R, van den Bosch JM, van Velzen-Blad H. Serum soluble interleukin-2 receptor measurement in patients with sarcoidosis: a clinical evaluation. Chest. 2003;124(1):186–95.

    Article  PubMed  Google Scholar 

  • Habash-Bseiso DE, Yale SH, Glurich I, Goldberg JW. Serologic testing in connective tissue diseases. Clin Med Res. 2005;3(3):190–3.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hayashi T. Dysfunction of lacrimal and salivary glands in Sjogren's syndrome: nonimmunologic injury in preinflammatory phase and mouse model. J Biomed Biotechnol. 2011;2011:407031.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hepburn A, Charles P. Antinuclear Factor. Rheumatology (Oxford). 2002;41(3):343–345.

    Article  PubMed  Google Scholar 

  • Ho KT, Reveille JD. The clinical relevance of autoantibodies in scleroderma. Arthritis Res Ther. 2003;5(2):80–93.

    Article  PubMed  PubMed Central  Google Scholar 

  • Holland SM. Chronic granulomatous disease. Hematol Oncol Clin North Am. 2013;27(1):89–99.

    Article  PubMed  Google Scholar 

  • Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. N Engl J Med. 2007;357(21):2153–65.

    Article  PubMed  Google Scholar 

  • Ion D, Stevenson K, Woo SB, Ho VT, Soiffer R, Antin JH, et al. Characterization of oral involvement in acute graft-versus-host disease. Biol Blood Marrow Transplant. 2014;20(11):1717–21.

    Article  PubMed  Google Scholar 

  • Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, et al. National Institutes of Health Consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 diagnosis and staging working group report. Biol Blood Marrow Transplant. 2015;21(3):389–401. e1

    Article  PubMed  Google Scholar 

  • Kalfa VC, Roberts RL, Stiehm ER. The syndrome of chronic mucocutaneous candidiasis with selective antibody deficiency. Ann Allergy Asthma Immunol. 2003;90(2):259–64.

    Article  PubMed  Google Scholar 

  • Kampgen E, Burg G, Wank R. Association of herpes simplex virus-induced erythema multiforme with the human leukocyte antigen DQw3. Arch Dermatol. 1988;124(9):1372–5.

    Article  PubMed  Google Scholar 

  • Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 2008;134(5):743–56.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kerr DA, McClatchey KD, Regezi JA. Allergic gingivostomatitis (due to gum chewing). J Periodontol. 1971;42(11):709–12.

    Article  PubMed  Google Scholar 

  • Kneisel A, Hertl M. Autoimmune bullous skin diseases. Part 2: diagnosis and therapy. J German Soc Dermatol. 2011;9(11):927–47.

    Google Scholar 

  • Lankarani KB, Sivandzadeh GR, Hassanpour S. Oral manifestation in inflammatory bowel disease: a review. World J Gastroenterol. 2013;19(46):8571–9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lee SJ. New approaches for preventing and treating chronic graft-versus-host disease. Blood. 2005;105(11):4200–6.

    Article  PubMed  PubMed Central  Google Scholar 

  • LeGoff J, Pere H, Belec L. Diagnosis of genital herpes simplex virus infection in the clinical laboratory. Virol J. 2014;11:83.

    Article  PubMed  PubMed Central  Google Scholar 

  • Loke WS, Herbert C, Thomas PS. Sarcoidosis: immunopathogenesis and immunological markers. Int J Chronic Dis. 2013;2013:928601.

    PubMed  PubMed Central  Google Scholar 

  • Lonial S, Durie B, Palumbo A, San-Miguel J. Monoclonal antibodies in the treatment of multiple myeloma: current status and future perspectives. Leukemia. 2016;30(3):526–35.

    Article  PubMed  Google Scholar 

  • Maeno N, Takei S, Imanaka H, Oda H, Yanagi K, Hayashi Y, et al. Anti-alpha-fodrin antibodies in Sjogren’s syndrome in children. J Rheumatol. 2001;28(4):860–4.

    PubMed  Google Scholar 

  • Mantovani A, Cassatella MA, Costantini C, Jaillon S. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol. 2011;11(8):519–31.

    Article  PubMed  Google Scholar 

  • Mattoo H, Mahajan VS, Della-Torre E, Sekigami Y, Carruthers M, Wallace ZS, et al. De novo oligoclonal expansions of circulating plasmablasts in active and relapsing IgG4-related disease. J Allergy Clin Immunol. 2014;134(3):679–87.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mehta TY, Prajapati LM, Mittal B, Joshi CG, Sheth JJ, Patel DB, Dave DM, Goyal RK. Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians. Indian J Dermatol Venereol Leprol. 2009;75(6):579–82.

    Article  PubMed  Google Scholar 

  • Migliorini P, Baldini C, Rocchi V, Bombardieri S. Anti-Sm and anti-RNP antibodies. Autoimmunity. 2005;38(1):47–54.

    Article  PubMed  Google Scholar 

  • Mihai S, Sitaru C. Immunopathology and molecular diagnosis of autoimmune bullous diseases. J Cell Mol Med. 2007;11(3):462–81.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mokhtarifar A, Ganji A, Sadrneshin M, Bahari A, Esmaeilzadeh A, Ghafarzadegan K, et al. Diagnostic value of ASCA and atypical p-ANCA in differential diagnosis of inflammatory bowel disease. Middle East J Dig Dis. 2013;5(2):93–7.

    PubMed  PubMed Central  Google Scholar 

  • Mowad CM, Anderson B, Scheinman P, Pootongkam S, Nedorost S, Brod B. Allergic contact dermatitis: patient management and education. J Am Acad Dermatol. 2016;74(6):1043–54.

    Article  PubMed  Google Scholar 

  • Nelson JL. Microchimerism and the pathogenesis of systemic sclerosis. Curr Opin Rheumatol. 1998;10(6):564–71.

    Article  PubMed  Google Scholar 

  • Ortolani C, Ispano M, Pastorello E, Bigi A, Ansaloni R. The oral allergy syndrome. Ann Allergy. 1988;61(6 Pt 2):47–52.

    PubMed  Google Scholar 

  • Ortolani C, Ispano M, Pastorello EA, Ansaloni R, Magri GC. Comparison of results of skin prick tests (with fresh foods and commercial food extracts) and RAST in 100 patients with oral allergy syndrome. J Allergy Clin Immunol. 1989;83(3):683–90.

    Article  PubMed  Google Scholar 

  • Pappalardo E, Cicardi M, Duponchel C, Carugati A, Choquet S, Agostoni A, et al. Frequent de novo mutations and exon deletions in the C1inhibitor gene of patients with angioedema. J Allergy Clin Immunol. 2000;106(6):1147–54.

    Article  PubMed  Google Scholar 

  • Park MA, Li JT, Hagan JB, Maddox DE, Abraham RS. Common variable immunodeficiency: a new look at an old disease. Lancet. 2008;372(9637):489–502.

    Article  PubMed  Google Scholar 

  • Perez-Aguilar MC, Goncalves L, Bonfante-Cabarcas R. Adenosine deaminase in severe combined immunodeficiency syndrome. Investig Clin. 2012;53:315–24.

    Google Scholar 

  • Popescu FD. Cross-reactivity between aeroallergens and food allergens. World J Methodol. 2015;5(2):31–50.

    Article  PubMed  PubMed Central  Google Scholar 

  • Preeti L, Magesh K, Rajkumar K, Karthik R. Recurrent aphthous stomatitis. J Oral Maxillofac Pathol. 2011;15(3):252–6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Prince HE, Ernst CE, Hogrefe WR. Evaluation of an enzyme immunoassay system for measuring herpes simplex virus (HSV) type 1-specific and HSV type 2-specific IgG antibodies. J Clin Lab Anal. 2000;14(1):13–6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Rodriguez J, Crespo JF, Lopez-Rubio A, De La Cruz-Bertolo J, Ferrando-Vivas P, Vives R, et al. Clinical cross-reactivity among foods of the Rosaceae family. J Allergy Clin Immunol. 2000;106(1 Pt 1):183–9.

    Article  PubMed  Google Scholar 

  • Sakaguchi S, Wing K, Miyara M. Regulatory T cells – a brief history and perspective. Eur J Immunol. 2007;37(Suppl 1):S116–23.

    Article  PubMed  Google Scholar 

  • Sakane T, Takeno M, Suzuki N, Inaba G. Behcet’s disease. N Engl J Med. 1999;341(17):1284–91.

    Article  PubMed  Google Scholar 

  • Savige J, Gillis D, Benson E, Davies D, Esnault V, Falk RJ, et al. International Consensus statement on testing and reporting of antineutrophil cytoplasmic antibodies (ANCA). Am J Clin Pathol. 1999;111(4):507–13.

    Article  PubMed  Google Scholar 

  • Savige J, Dimech W, Fritzler M, Goeken J, Hagen EC, Jennette JC, et al. Addendum to the international Consensus statement on testing and reporting of antineutrophil cytoplasmic antibodies. Quality control guidelines, comments, and recommendations for testing in other autoimmune diseases. Am J Clin Pathol. 2003;120(3):312–8.

    Article  PubMed  Google Scholar 

  • Schroeder HW Jr, Cavacini L. Structure and function of immunoglobulins. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S41–52.

    Article  PubMed  PubMed Central  Google Scholar 

  • Self SE. Autoantibody testing for autoimmune disease. Clin Chest Med. 2010;31(3):415–22.

    Article  PubMed  Google Scholar 

  • Sharfe N, Nahum A, Newell A, Dadi H, Ngan B, Pereira SL, et al. Fatal combined immunodeficiency associated with heterozygous mutation in STAT1. J Allergy Clin Immunol. 2014;133(3):807–17.

    Article  PubMed  Google Scholar 

  • Sherer Y, Gorstein A, Fritzler MJ, Shoenfeld Y. Autoantibody explosion in systemic lupus erythematosus: more than 100 different antibodies found in SLE patients. Semin Arthritis Rheum. 2004;34(2):501–37.

    Article  PubMed  Google Scholar 

  • Shiohara T, Moriya N, Nagashima M. Induction and control of lichenoid tissue reactions. Springer Semin Immunopathol. 1992;13(3–4):369–85.

    PubMed  Google Scholar 

  • Singh A, Preiksaitis J, Ferenczy A, Romanowski B. The laboratory diagnosis of herpes simplex virus infections. Can J Infect Dis Med Microbiol. 2005;16(2):92–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sinico RA, Radice A. Antineutrophil cytoplasmic antibodies (ANCA) testing: detection methods and clinical application. Clin Exp Rheumatol. 2014;32(3 Suppl 82):S112–7.

    PubMed  Google Scholar 

  • Smetana GW, Landon BE, Bindman AB, Burstin H, Davis RB, Tjia J, et al. A comparison of outcomes resulting from generalist vs specialist care for a single discrete medical condition: a systematic review and methodologic critique. Arch Intern Med. 2007;167(1):10–20.

    Article  PubMed  Google Scholar 

  • Sokumbi O, Wetter DA. Clinical features, diagnosis, and treatment of erythema multiforme: a review for the practicing dermatologist. Int J Dermatol. 2012;51(8):889–902.

    Article  PubMed  Google Scholar 

  • Somkrua R, Eickman EE, Saokaew S, Lohitnavy M, Chaiyakunapruk N. Association of HLA-B*5801 allele and allopurinol-induced Stevens Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis. BMC Med Genet. 2011;12:118.

    Article  PubMed  PubMed Central  Google Scholar 

  • Stinton LM, Fritzler MJ. A clinical approach to autoantibody testing in systemic autoimmune rheumatic disorders. Autoimmun Rev. 2007;7(1):77–84.

    Article  PubMed  Google Scholar 

  • Stojanov IJ, Woo SB. Human papillomavirus and Epstein-Barr virus associated conditions of the oral mucosa. Semin Diagn Pathol. 2015;32(1):3–11.

    Article  PubMed  Google Scholar 

  • Stone JH, Khosroshahi A, Deshpande V, Chan JK, Heathcote JG, Aalberse R, Azumi A, Bloch DB, Brugge WR, Carruthers MN, Cheuk W, Cornell L, Castillo CF, Ferry JA, Forcione D, Klöppel G, Hamilos DL, Kamisawa T, Kasashima S, Kawa S, Kawano M, Masaki Y, Notohara K, Okazaki K, Ryu JK, Saeki T, Sahani D, Sato Y, Smyrk T, Stone JR, Takahira M, Umehara H, Webster G, Yamamoto M, Yi E, Yoshino T, Zamboni G, Zen Y, Chari S. Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations. Arthritis Rheum. 2012;64(10):3061–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Stukus DR, Mikhail I. Pearls and pitfalls in diagnosing IgE-mediated food allergy. Curr Allergy Asthma Rep. 2016;16(5):34.

    Article  PubMed  Google Scholar 

  • Tan EM, Feltkamp TE, Smolen JS, Butcher B, Dawkins R, Fritzler MJ, et al. Range of antinuclear antibodies in “healthy” individuals. Arthritis Rheum. 1997;40(9):1601–11.

    Article  PubMed  Google Scholar 

  • Teo EC, Chew Y, Phipps C. A review of monoclonal antibody therapies in lymphoma. Crit Rev Oncol Hematol. 2016 Jan;97:72–84.

    Article  PubMed  Google Scholar 

  • Turvey SE, Broide DH. Innate immunity. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S24–32.

    Article  PubMed  Google Scholar 

  • van de Veerdonk FL, Plantinga TS, Hoischen A, Smeekens SP, Joosten LA, Gilissen C, et al. STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis. N Engl J Med. 2011;365(1):54–61.

    Article  PubMed  Google Scholar 

  • Virgo PF, Gibbs GJ. Flow cytometry in clinical pathology. Ann Clin Biochem. 2012;49(Pt 1):17–28.

    Article  PubMed  Google Scholar 

  • Vivier E, Tomasello E, Baratin M, Walzer T, Ugolini S. Functions of natural killer cells. Nat Immunol. 2008;9(5):503–10.

    Article  PubMed  Google Scholar 

  • Voehringer D. Protective and pathological roles of mast cells and basophils. Nat Rev Immunol. 2013;13(5):362–75.

    Article  PubMed  Google Scholar 

  • Warrington R, Watson W, Kim HL, Antonetti FR. An introduction to immunology and immunopathology. Allergy, Asthma Clin Immunol. 2011;1(7 Suppl):S1.

    Article  Google Scholar 

  • Williams V, Gershon A, Brunell PA. Serologic response to varicella-zoster membrane antigens measured by direct immunofluorescence. J Infect Dis. 1974;130(6):669–72.

    Article  PubMed  Google Scholar 

  • Woo SB. Oral pathology: a comprehensive atlas and text 2012.

    Google Scholar 

  • Workowski KA. Centers for Disease Control and Prevention sexually transmitted diseases treatment guidelines. Clin Infect Dis. 2015;61(Suppl 8):S759–62.

    Article  PubMed  Google Scholar 

  • Yuan A, Woo SB. Adverse drug events in the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119(1):35–47.

    Article  PubMed  Google Scholar 

  • Zuraw BL, Bernstein JA, Lang DM, Craig T, Dreyfus D, Hsieh F, et al. A focused parameter update: hereditary angioedema, acquired C1 inhibitor deficiency, and angiotensin-converting enzyme inhibitor-associated angioedema. J Allergy Clin Immunol. 2013;131(6):1491–3.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA

    Nathaniel Treister & Alessandro Villa

  2. Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Arturo Saavedra

  3. Division of Oral Medicine and Dentistry, Brigham and Women’s Hospital, Boston, MA, USA

    Alessandro Villa

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  1. Nathaniel Treister
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  2. Arturo Saavedra
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  3. Alessandro Villa
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Corresponding author

Correspondence to Nathaniel Treister .

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Editors and Affiliations

  1. UWA Dental School and Oral Health Centre of Western Australia, Faculty of Health and Medical Sciences University of Western Australia, Perth, WA, Australia

    Camile S. Farah

  2. UWA Dental School and Oral Health Centre of Western Australia, Faculty of Health and Medical Sciences University of Western Australia, Perth, WA, Australia

    Ramesh Balasubramaniam

  3. Oral Anatomy, Medicine, and Surgery Section Melbourne Dental School, Faculty of Medicine, Dentistry and Health Sciences The University of Melbourne, Carlton, VIC, Australia

    Michael J. McCullough

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Treister, N., Saavedra, A., Villa, A. (2019). Clinical Immunology in Diagnoses of Maxillofacial Disease. In: Farah, C., Balasubramaniam, R., McCullough, M. (eds) Contemporary Oral Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-72303-7_5

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