Synonyms
Abrikossoff’s tumor, Granular cell myoblastoma
Definition
Granular cell tumor (GCT) is a rare tumor, of neurogenic derivation, composed of cells with pale and granular cytoplasm.
Clinical Features
Incidence
GCT usually arises in the tongue, but all the organs can be affected. About 6% of GCT arises in the breast (Damiani et al. 1992; Sanguinetti et al. 2016; Rexeena et al. 2015).
Age
Breast GCT most frequently presents in middle aged women, but age can vary from puberty to elderly ladies aged more than 70 years (Torous et al. 2017).
Sex
Breast GCT affects more frequently female patients, but rare cases have been reported in males (Damiani et al. 1992). African-American women are more frequently affected than Caucasian women (Torous et al. 2017).
Site
GCT is usually located in the upper-internal quadrant of the breast, even if all the breast quadrants can be affected, comprising the axillary tail (Damiani et al. 1992, Torous et al. 2017). GCT of the breast can be located both...
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References
Damiani, S., Koerner, F. C., Dickersin, G. R., Cook, M. G., & Eusebi, V. (1992). Granular cell tumour of the breast. Virchows Archiv. A, Pathological Anatomy and Histopathology, 420(3), 219–226.
Damiani, S., Dina, R., & Eusebi, V. (1999). Eosinophilic and granular cell tumors of the breast. Seminars in Diagnostic Pathology, 16(2), 117–125.
Eusebi, V., Foschini, M. P., Bussolati, G., & Rosen, P. P. (1995). Myoblastomatoid (histiocytoid) carcinoma of the breast. A type of apocrine carcinoma. The American Journal of Surgical Pathology, 19(5), 553–562.
Rexeena, B., Paul, A., Nitish, R. A., Kurian, C., & Anila, R. K. (2015). Granular cell tumor of breast: A case report and review of literature. Indian Journal of Surgical Oncology, 6(4), 446–448.
Sanguinetti, A., Polistena, A., Lucchini, R., Monacelli, M., Galasse, S., Avenia, S., Bugiantella, W., Triola, R., Cirocchi, R., Rondelli, R., & Avenia, N. (2016). Myoblastoma of the breast: Our experience and review of literature. International Journal of Surgery Case Reports, 20S, 5–7.
Schrader, K. A., Nelson, T. N., De Luca, A., Huntsman, D. G., & McGillivray, B. C. (2009). Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11. Clinical Genetics, 75(2), 185–189.
Tavassoli, F. A., & Eusebi, V. (2009). Benign soft tissue lesions. In Tumors of the mammary gland (FIP Atlas of tumor pathology, series 4, p. 281). Washington, DC: American Registry of Pathology in collaboration with the Armed Forces Institute of Pathology.
Torous, V., Schnitt, S. J., & Collins, L. C. (2017). Benign breast lesions that mimic malignancy. Pathology, 49(2), 181–196.
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Foschini, M.P., Morandi, L. (2020). Granular Cell Tumor. In: Sapino, A., Kulka, J. (eds) Breast Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-62539-3_4709
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DOI: https://doi.org/10.1007/978-3-319-62539-3_4709
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