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Disorders of Keratinization

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Atlas of Dermatology, Dermatopathology and Venereology

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Abstract

Hereditary keratinization disorders are inherited skin diseases characterized by abnormal keratinization. The formation of an abnormal stratum corneum and hyperkeratotic skin lesions are the common characteristics of this group of diseases. In some of these disorders, the mechanism of hyperkeratosis has been elucidated. Increased production (proliferation hyperkeratosis) and increased adhesiveness of the stratum corneum (retention hyperkeratosis) define the two main pathophysiologic subdivisions of scaling diseases.

Acquired cases of keratinization disorders are seen in association with inflammatory disorders, systemic disorders, infectious disorders, and medication.

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Authors and Affiliations

  1. Faculty of Medicine, Department of Dermatology, Al Manar 2 University, La Rabta hospital, Tunis, Tunisia

    Asmahane Souissi, Nourchène Toukebri, Ines Chelly, Wissem Hafsi & Mourad Mokni

  2. Pasteur Institute, Laboratory of Biomedical Genomics and Onco-genetics (LR11IPT05), Tunis, Tunisia

    Nadia Laaroussi, Sonia Abdelhak & Samir Boubaker

  3. Higher Institute of Biotechnology of Sidi-Thabet, Molecular and GeneticBiology, Tunis, Tunisia

    Cherine Charfeddine

Authors
  1. Asmahane Souissi
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  2. Nourchène Toukebri
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  3. Ines Chelly
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  4. Nadia Laaroussi
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Correspondence to Mourad Mokni .

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Editors and Affiliations

  1. Department of Pathology, Univ of Rochester School of Med, Rochester, NY, USA

    Bruce Smoller

  2. Khorramshahr, Iran

    Nooshin Bagherani

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Souissi, A. et al. (2021). Disorders of Keratinization. In: Smoller, B., Bagherani, N. (eds) Atlas of Dermatology, Dermatopathology and Venereology . Springer, Cham. https://doi.org/10.1007/978-3-319-45134-3_23-1

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  • DOI: https://doi.org/10.1007/978-3-319-45134-3_23-1

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