Synonyms
Jadassohn’s nevus; Nevus sebaceus of Jadassohn; Organoid nevus
Definition
Nevus Sebaceus (NS) is a congenital hamartomatous lesion of the skin of embryonal ectodermal origin. It is thought to derive from postzygotic somatic mutations involving pluripotential cells of the primary epithelial germ. The primary epithelial germ normally gives rise to the folliculo-sebaceous unit and to the apocrine glands. NS is characterized by abnormalities of the epidermis, the hair follicle, and the sebaceous and apocrine glands. The aspect of these changes varies according to the age of the patient (Alessi and Sala 1986; Morioka 1985). Nevus sebaceus is associated with benign and rarer malignant tumors that develop in the lesions, mostly during adulthood, in 5–15 % of the patients (Cribier et al. 2000).
Nevus sebaceus is often isolated and rarely syndromic. In the latter case, it is associated with cutaneous and extracutaneous abnormalities, in various congenital syndromes, among which the...
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References and Further Reading
Alessi, E., & Sala, F. (1986). Nevus sebaceus: A clinicopathologic study of its evolution. American Journal of Dermatopathology, 8, 27–31.
Carlson, J. A., Cribier, B., Nuovo, G., & Rohwedder, A. (2008). Epidermodysplasia verruciformis-associated and genital-mucosal high-risk human papillomavirus DNA are prevalent in nevus sebaceus of jadassohn. Journal of the American Academy of Dermatology, 59, 279–294.
Cribier, B., Scrivener, Y., & Grosshans, E. (2000). Tumors arising in nevus sebaceus: A study of 596 cases. Journal of the American Academy of Dermatology, 42, 263–268.
Eisen, D. B., & Michael, D. J. (2009). Sebaceous lesions and their associated syndromes: Part II. Journal of the American Academy of Dermatology, 61, 563–578.
Morioka, S. (1985). The natural history of nevus sebaceus. Journal of Cutaneous Pathology, 12, 200–213.
Santibanez-Gallerani, A., Marshall, D., Duarte, A. M., Melnick, S. J., & Thaller, S. (2003). Should nevus sebaceus of Jadassohn in children be excised? A study of 757 cases, and literature review. The Journal of Craniofacial Surgery, 14, 658–660.
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Battistella, M., Cribier, B. (2016). Nevus Sebaceus. In: Massi, D. (eds) Dermatopathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-30006-1_459
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DOI: https://doi.org/10.1007/978-3-319-30006-1_459
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