Synopsis
The nucleotide excision repair (NER) pathway is a highly efficient and versatile mechanism for the repair of bulky DNA lesions. The majority of such lesions arise exogenously, such as those inflicted by UV light exposure or DNA-alkylating carcinogens. The NER pathway consists of sequential steps of damage recognition, helix unwinding, introduction of dual incisions, and repair resynthesis. A total of 26 gene products are directly involved in the removal of a bulky adduct lesion and the restoration of the damaged portion of the genome. Mutations in NER genes lead to the recessively inherited and highly cancer-prone syndrome xeroderma pigmentosum (XP).
Introduction
The basic building blocks of DNA are deoxyribonucleotides. Each deoxyribonucleotides consists of a phosphate, a deoxyribose, and a nitrogenous base. The chemical natures of these basic components and the phosphodiester bond that joint them to form the DNA strand dictate that DNA is highly reactive. Not only does DNA...
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Li, L. (2018). Nucleotide Excision Repair. In: Wells, R.D., Bond, J.S., Klinman, J., Masters, B.S.S. (eds) Molecular Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1531-2_62
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DOI: https://doi.org/10.1007/978-1-4614-1531-2_62
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