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Influence of Social Defeat Stress on the Rewarding Effects of Drugs of Abuse

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Methods for Preclinical Research in Addiction

Part of the book series: Neuromethods ((NM,volume 174))

Abstract

Drug addiction is a serious problem in our society. Some individuals develop dependence to different substances very accessible in the market, mainly young people. It is known that different biological and environmental variables facilitate the initiation, maintenance and relapse to drug use. In this sense, social stress is an important factor involved in the development of drug addiction and animal models are an optimal tool to study neurobiological systems associated with stress and addictive disorders. Among the main paradigms of social stress, the social defeat in an agonistic encounter with a conspecific male rodent has a notable ethological validity. Two main procedures, “acute” or “repeated” social defeat, may be distinguished, being the main differences between both the duration and intensity of the social defeat episodes and the evaluation of their short/long-term effects. Indeed, it has been demonstrated that the effects of both types of stress on the self-administration or conditioned place preference induced by different drugs are different. Although acute and repeated social defeat procedures have some limitations, in general terms both paradigms can help us to draw conclusions about the relationship between stress and drug addiction.

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  • 02 March 2022

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Authors and Affiliations

  1. Department of Psychology and Sociology, Faculty of Social Sciences, University of Zaragoza (Campus Teruel), Teruel, Spain

    María Pilar García-Pardo

  2. Unit of Research ‘Neurobehavioral Mechanisms and Endophenotypes of Addictive Behavior,’ Department of Psychobiology, Faculty of Psychology, University of Valencia, Valencia, Spain

    Claudia Calpe-López, M. Ángeles Martínez-Caballero & María A. Aguilar

  3. Faculty of Nursing, Catholic University of Valencia, Valencia, Spain

    José Enrique De la Rubia-Ortí, Claudia Calpe-López, M. Ángeles Martínez-Caballero & María A. Aguilar

Authors
  1. María Pilar García-Pardo
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  2. José Enrique De la Rubia-Ortí
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  3. Claudia Calpe-López
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  4. M. Ángeles Martínez-Caballero
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  5. María A. Aguilar
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Correspondence to María Pilar García-Pardo .

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  1. Unit of Research “Neurobehavioral Mechanisms and Endophenotypes of Addictive Behavior” Department of Psychobiology, Faculty of Psychology, University of Valencia, Valencia, Spain

    María A. Aguilar

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García-Pardo, M.P., De la Rubia-Ortí, J.E., Calpe-López, C., Martínez-Caballero, M.Á., Aguilar, M.A. (2022). Influence of Social Defeat Stress on the Rewarding Effects of Drugs of Abuse. In: Aguilar, M.A. (eds) Methods for Preclinical Research in Addiction. Neuromethods, vol 174. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1748-9_8

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  • DOI: https://doi.org/10.1007/978-1-0716-1748-9_8

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