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Transcranial Direct Current Stimulation to Reduce Addiction-Related Behaviors in Mice

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Methods for Preclinical Research in Addiction

Part of the book series: Neuromethods ((NM,volume 174))

Abstract

Transcranial direct current stimulation (tDCS) is a neuromodulation method used in humans to increase or decrease cortical excitability in a noninvasive and painless manner. A weak electric current flows between two electrodes, an anode and a cathode, placed on the scalp. This technique has gained considerable interest recently as a tool for the treatment of several psychiatric disorders, including depression and addiction. However, the mechanisms underlying its beneficial effects remain poorly understood, requiring further investigations in human as well as animal models. In Besançon (Laboratoire de Recherches Intégratives en Neurosciences et Psychologie Cognitive, Université Bourgogne Franche-Comté), we have developed a mouse model of tDCS to study its mechanisms of action, using a stimulation protocol similar to those in clinical trials. In this chapter, we will describe this model and its different variants (i.e., tDCS on awake restrained mice; tDCS on anesthetized mice; tDCS in freely moving mice).

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Authors and Affiliations

  1. Laboratoire de Recherches Intégratives en Neurosciences et Psychologie Cognitive, Université Bourgogne Franche-Comté, Besançon, France

    Stéphanie Dumontoy, Adeline Etievant & Vincent Van Waes

  2. Department of Pharmaceutical Sciences, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium

    Andries Van Schuerbeek

Authors
  1. Stéphanie Dumontoy
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  2. Adeline Etievant
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  3. Andries Van Schuerbeek
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  4. Vincent Van Waes
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Corresponding author

Correspondence to Vincent Van Waes .

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Editors and Affiliations

  1. Unit of Research “Neurobehavioral Mechanisms and Endophenotypes of Addictive Behavior” Department of Psychobiology, Faculty of Psychology, University of Valencia, Valencia, Spain

    María A. Aguilar

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Dumontoy, S., Etievant, A., Van Schuerbeek, A., Van Waes, V. (2022). Transcranial Direct Current Stimulation to Reduce Addiction-Related Behaviors in Mice. In: Aguilar, M.A. (eds) Methods for Preclinical Research in Addiction. Neuromethods, vol 174. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1748-9_12

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  • DOI: https://doi.org/10.1007/978-1-0716-1748-9_12

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1747-2

  • Online ISBN: 978-1-0716-1748-9

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