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Network Pharmacology to Clarify the Effective Substances and Their Action Mechanisms of Traditional Chinese Medicines

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Quality Control of Chinese Medicines

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Abstract

Traditional Chinese medicines (TCMs) were applied to treat various biological diseases with a long history. TCMs are characterized by multiple components corresponding to abundant targets and holistic effects in body. The network pharmacology, as a constructive technology integrating multiple sources of information, not only considers the pharmacology response of TCMs in cellular or phenotypic levels, but also reflects the characterization of chemical material basis in TCMs. It is very crucial to fully consider the source of chemical components representing the whole TCM for expanding its network pharmacology research. More persuasive multi-component network pharmacology would be conducive to elucidate the quality control and therapeutic mechanism of TCMs.

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Abbreviations

TCM:

Traditional Chinese Medicine

KEGG:

Kyoto Encyclopedia of Genes and Genomes

TCMSP:

Traditional Chinese Medicine Systems Pharmacology

POI:

Premature Ovarian Insufficiency

SR:

Scutellariae Radix

RA:

Rheumatoid Arthritis

YBTC:

Yaobitong Capsule

DLT:

Danlou Tablet

NAFLD:

Non-alcoholic Fatty Liver Disease

EGFR:

Epidermal Growth Factor Receptor

NSCLC:

Non-small Cell Lung Cancer

VEGF:

Vascular Endothelial Growth Factor

DQTT:

Danqi Tongmai Tablet

HPLC:

High Performance Liquid Chromatography-Mass Spectrometry

GC-MS:

Gas Chromatography-Mass Spectrometry

PPAR:

Peroxisome Proliferators-Activated Receptors

FXR:

Farnesoid X Receptor

HZTF:

Huzhen Tongfeng Formula

OSPF:

Ontology-based Side effect Prediction Framework

ANN:

Artificial Neural network

AI:

Artificial Intelligence

CNN:

Convolutional Neural Network

References

  1. C. Liu, H. Wu, L. Wang, H. Luo, Y. Lu, Q. Zhang, L. Tang, Z. Wang, Farfarae Flos: a review of botany, traditional uses, phytochemistry, pharmacology, and toxicology. J. Ethnopharmacol. 260, 113038 (2020)

    Article  CAS  PubMed  Google Scholar 

  2. W. Zhang, Q. **e, X. Xu, S. Sun, T. Fan, X. Wu, Y. Qu, J. Che, T. Huang, H. Li, Y. Zheng, C. Jiang, B. Fang, S. Zhou, Baidu Jieduan granules, traditional Chinese medicine, in the treatment of moderate coronavirus disease-2019 (COVID-19): study protocol for an open-label, randomized controlled clinical trial. Trials 22, 476 (2021)

    Google Scholar 

  3. C. Li, C.Z. Sun, Y.H. Yang, N. Ma, Y.J. Wang, F.X. Zhang, Y.H. Pei, A novel strategy by integrating chemical profiling, molecular networking, chemical isolation, and activity evaluation to target isolation of potential anti-ACE2 candidates in Forsythiae Fructus. Phytomedicine 96, 153888 (2022)

    Google Scholar 

  4. R. Qiao, L. Zhou, M. Zhong, M. Zhang, L. Yang, Y. Yang, H. Chen, W. Yang, J. Yuan, Spectrum-effect relationship between UHPLC-Q-TOF/MS fingerprint and promoting gastrointestinal motility activity of Fructus aurantii based on multivariate statistical analysis. J. Ethnopharmacol. 279, 114366 (2021)

    Google Scholar 

  5. Y. Zhang, Y.Y. Zhou, W.Y. Gao, M.Y. Cui, B.L. Bian, L.Q. Ni, K. Wang, H.J. Wang, N. Si, H.Y. Zhao, Identification of chemical constituents of **aoer Chiqiao Qingre Granules based on UHPLC-LTQ-Orbitrap-MS/MS and network pharmacology analysis. Zhongguo Zhong Yao Za Zhi. 46, 6163–6177 (2021)

    Google Scholar 

  6. S. Li, T.P. Fan, W. Jia, A. Lu, W. Zhang, Network pharmacology in traditional chinese medicine. Evid Based Complement Alternat. Med. 2014, 138460 (2014)

    PubMed  PubMed Central  Google Scholar 

  7. L. Zhou, L. Zhang, D. Tao, Investigation on the mechanism of Qubi formula in treating psoriasis based on network pharmacology. Evid Based Complement Alternat. Med.: eCAM 2020, 4683254 (2020)

    Article  PubMed  PubMed Central  Google Scholar 

  8. D. Cheng, G. Murtaza, S. Ma, L. Li, X. Li, F. Tian, J. Zheng, Y. Lu, In Silico prediction of the anti-depression mechanism of a herbal formula (Tiansi Liquid) containing Morinda officinalis and Cuscuta chinensis, Molecules (Basel, Switzerland) 22 (2017)

    Google Scholar 

  9. S. Long, C. Yuan, Y. Wang, J. Zhang, G. Li, Network pharmacology analysis of Damnacanthus indicus C.F.Gaertn in Gene-Phenotype. Evid. Based Complement. Alternat. Med.: eCAM 2019, 1368371 (2019)

    Google Scholar 

  10. Q. Li, C. Bai, R. Yang, W. **ng, X. Pang, S. Wu, S. Liu, J. Chen, T. Liu, X. Gu, Deciphering the pharmacological mechanisms of Ma **ng Shi Gan decoction against COVID-19 through integrating network pharmacology and experimental exploration. Front. Pharmacol. 11, 581691 (2020)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. H.Y. Lin, J.C. Tsai, L.Y. Wu, W.H. Peng, Reveals of new candidate active components in hemerocallis radix and its anti-depression action of mechanism based on network pharmacology approach. Int. J. Mol. Sci. 21 (2020)

    Google Scholar 

  12. F. Liu, Q. Zhao, S. Liu, Y. Xu, D. Zhou, Y. Gao, L. Zhu, Revealing the pharmacological mechanism of Acorus tatarinowii in the treatment of ischemic stroke based on network pharmacology. Evid. Based Complement. Alternat. Med.: eCAM 2020, 3236768 (2020)

    Article  PubMed  PubMed Central  Google Scholar 

  13. X. Tan, W. Pei, C. **e, Z. Wang, T. Mao, X. Zhao, F. Kou, Q. Lu, Z. Sun, X. Xue, J. Li, Network pharmacology identifies the mechanisms of action of Tongxie Anchang decoction in the treatment of irritable bowel syndrome with diarrhea predominant. Evid. Based Complement. Alternat. Med.: eCAM 2020, 2723705 (2020)

    Article  PubMed  PubMed Central  Google Scholar 

  14. R. Zhang, X. Zhu, H. Bai, K. Ning, Network pharmacology databases for traditional Chinese medicine: review and assessment. Front. Pharmacol. 10, 123 (2019)

    Article  PubMed  PubMed Central  Google Scholar 

  15. C. Lu, Z. Bing, Z. Bi, M. Liu, T. Lu, Y. Xun, Z. Wei, K. Yang, Top-100 most cited publications concerning network pharmacology: a bibliometric analysis. Evid. Based Complement. Alternat. Med.: eCAM 2019, 1704816 (2019)

    Article  PubMed  PubMed Central  Google Scholar 

  16. H. Zhao, Y. Shan, Z. Ma, M. Yu, B. Gong, A network pharmacology approach to explore active compounds and pharmacological mechanisms of epimedium for treatment of premature ovarian insufficiency. Drug Des. Dev. Ther. 13, 2997–3007 (2019)

    Article  CAS  Google Scholar 

  17. Y. Qu, X. Yang, J. Li, S. Zhang, S. Li, M. Wang, L. Zhou, Z. Wang, Z. Lin, Y. Yin, J. Liu, N. Wang, Y. Yang, Network pharmacology and molecular docking study of Zhishi-Baizhu Herb Pair in the treatment of gastric cancer. Evid. Based Complement. Alternat. Med. 2311486 (2021)

    Google Scholar 

  18. Q. Zhang, Z. Feng, M. Gao, L. Guo, Determining novel candidate anti-hepatocellular carcinoma drugs using interaction networks and molecular docking between drug targets and natural compounds of SiNiSan. PeerJ 9, e10745 (2021)

    Article  PubMed  PubMed Central  Google Scholar 

  19. C.L. Piao, J.L. Luo, D. **, C. Tang, L. Wang, F.M. Lian, X.L. Tong, Utilizing network pharmacology to explore the underlying mechanism of Radix Salviae in diabetic retinopathy. Chin. Med. 14, 58 (2019)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Q. Wang, Y. Liang, C. Peng, P. Jiang, Network pharmacology-based study on the mechanism of Scutellariae Radix for Hepatocellular Carcinoma treatment. Evid. Based Complement. Alternat. Med. 2020, 8897918 (2020)

    PubMed  PubMed Central  Google Scholar 

  21. M. Wei, H. Li, Q. Li, Y. Qiao, Q. Ma, R. **e, R. Wang, Y. Liu, C. Wei, B. Li, C. Zheng, B. Sun, B. Yu, Based on network pharmacology to explore the molecular targets and mechanisms of Gegen Qinlian decoction for the treatment of ulcerative colitis. Biomed. Res. Int. 2020, 5217405 (2020)

    Article  PubMed  PubMed Central  Google Scholar 

  22. J.L. Gu, G.L. Wei, Y.Z. Ma, J.Z. Zhang, Y. Ji, L.C. Li, J.L. Yu, C.H. Hu, J.G. Huo, Exploring the possible mechanism and drug targets of Huang-Qi-Gui-Zhi-Wu-Wu decoction for the treatment of chemotherapy-induced peripheral neuropathy on network pharmacology. Evid. Based Complement. Alternat. Med.: eCAM 2020, 2363262 (2020)

    Article  PubMed  PubMed Central  Google Scholar 

  23. R.F. Hu, X.B. Sun, Design of new traditional Chinese medicine herbal formulae for treatment of type 2 diabetes mellitus based on network pharmacology. Chin. J. Nat. Med. 15, 436–441 (2017)

    PubMed  Google Scholar 

  24. J. Gao, T. Wang, X. Yao, W. **e, X. Shi, S. He, T. Zhao, C. Wang, Y. Zhu, Clinical evidence-guided network pharmacology analysis reveals a critical contribution of β1-adrenoreceptor upregulation to bradycardia alleviation by Shenxian-Shengmai. BMC Complement. Altern. Med. 19, 357 (2019)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. D. Wu, X. Zhang, L. Liu, Y. Guo, Key CMM combinations in prescriptions for treating mastitis and working mechanism analysis based on network pharmacology. Evid. Based Complement. Alternat. Med. 2019, 8245071 (2019)

    Article  PubMed  PubMed Central  Google Scholar 

  26. H. **ong, Z. Dong, G. Lou, Q. Gan, J. Wang, Q. Huang, Analysis of the mechanism of Shufeng Jiedu capsule prevention and treatment for COVID-19 by network pharmacology tools. European J. Integrat. Med. 40, 101241 (2020)

    Article  Google Scholar 

  27. Z. Chen, P. Chen, H. Wu, R. Shi, W. Su, Y. Wang, P. Li, Evaluation of Naringenin as a promising treatment option for COPD based on literature review and network pharmacology. Biomolecules 10 (2020)

    Google Scholar 

  28. X. Lv, H. Wang, R. Wu, X. Shen, G. Ye, The active compounds of Yixin Ningshen tablet and their potential action mechanism in treating coronary heart disease—A network pharmacology and proteomics approach. Evid. Based Complement Alternat. Med.: eCAM 2020, 4912395 (2020)

    Article  PubMed  PubMed Central  Google Scholar 

  29. L. Pan, Z. Li, Y. Wang, B. Zhang, G. Liu, J. Liu, Network pharmacology and metabolomics study on the intervention of traditional Chinese medicine Huanglian Decoction in rats with type 2 diabetes mellitus. J. Ethnopharmacol. 258, 112842 (2020)

    Article  CAS  PubMed  Google Scholar 

  30. J. Yang, S. Tian, J. Zhao, W. Zhang, Exploring the mechanism of TCM formulae in the treatment of different types of coronary heart disease by network pharmacology and machining learning. Pharmacol. Res. 159, 105034 (2020)

    Article  CAS  PubMed  Google Scholar 

  31. J. Zuo, X. Wang, Y. Liu, J. Ye, Q. Liu, Y. Li, S. Li, Integrating network pharmacology and metabolomics study on anti-rheumatic mechanisms and antagonistic effects against methotrexate-induced toxicity of Qing-Luo-Yin. Front. Pharmacol. 9, 1472 (2018)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. S. Huang, Z. Zhang, W. Li, F. Kong, P. Yi, J. Huang, D. Mao, W. Peng, S. Zhang, Network pharmacology-based prediction and verification of the active ingredients and potential targets of Zuo**wan for treating colorectal cancer. Drug Des. Dev. Ther. 14, 2725–2740 (2020)

    Article  CAS  Google Scholar 

  33. H.Z. Liang, Z.Y. Du, S. Yuan, M.Q. Lu, J.Y. **ng, Q. Ma, Z.Z. Han, P.F. Tu, Y. Jiang, Comparison of Murraya exotica and Murraya paniculata by fingerprint analysis coupled with chemometrics and network pharmacology methods, Chin. J. Nat. Med. 19, 713–720 (2021)

    CAS  Google Scholar 

  34. M. Zhao, M. Hao, H. Tong, L. Su, C. Fei, W. Gu, J. Mao, T. Lu, C. Mao, Screening of blood-activating active components from Curcuma wenyu** Y.H. Chen et C. Ling rhizome based on spectrum-effect relationship analysis and network pharmacology, J. Chromatogr. B Analyt. Technol. Biomed. Life. Sci. 1188, 123022 ((2022))

    Google Scholar 

  35. M. Ding, W. Ma, X. Wang, S. Chen, S. Zou, J. Wei, Y. Yang, J. Li, X. Yang, H. Wang, Y. Li, Q. Wang, H. Mao, X.M. Gao, Y.X. Chang, A network pharmacology integrated pharmacokinetics strategy for uncovering pharmacological mechanism of compounds absorbed into the blood of Dan-Lou tablet on coronary heart disease. J. Ethnopharmacol. 242, 112055 (2019)

    Article  CAS  PubMed  Google Scholar 

  36. Y. Deng, X. Gao, T. Feng, Z. Wang, W. **ao, Z. **ong, L. Zhao, Systematically characterized mechanism of treatment for lumbar disc herniation based on Yaobitong capsule ingredient analysis in rat plasma and its network pharmacology strategy by UPLC-MS/MS. J. Ethnopharmacol. 260, 113097 (2020)

    Article  CAS  PubMed  Google Scholar 

  37. S.M. Ren, Q.Z. Zhang, M. Jiang, M.L. Chen, X.J. Xu, D.M. Wang, Y.N. Pan, X.Q. Liu, Systematic characterization of the metabolites of defatted walnut powder extract in vivo and screening of the mechanisms against NAFLD by UPLC-Q-Exactive Orbitrap MS combined with network pharmacology. J. Ethnopharmacol. 285, 114870 (2022)

    Article  CAS  PubMed  Google Scholar 

  38. Q.D. **a, Y. Xun, J.L. Lu, Y.C. Lu, Y.Y. Yang, P. Zhou, J. Hu, C. Li, S.G. Wang, Network pharmacology and molecular docking analyses on Lianhua Qingwen capsule indicate Akt1 is a potential target to treat and prevent COVID-19. Cell Prolif. 53, e12949 (2020)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. G. Yu, W. Wang, X. Wang, M. Xu, L. Zhang, L. Ding, R. Guo, Y. Shi, Network pharmacology-based strategy to investigate pharmacological mechanisms of Zuo**wan for treatment of gastritis. BMC Complement. Altern. Med. 18, 292 (2018)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. B. Yin, Y.M. Bi, G.J. Fan, Y.Q. **a, Molecular mechanism of the effect of Huanglian Jiedu decoction on type 2 diabetes mellitus based on network pharmacology and molecular docking. J. Diabetes Res. 2020, 5273914 (2020)

    Article  PubMed  PubMed Central  Google Scholar 

  41. X. Zhang, T. Shen, X. Zhou, X. Tang, R. Gao, L. Xu, L. Wang, Z. Zhou, J. Lin, Y. Hu, Network pharmacology based virtual screening of active constituents of Prunella vulgaris L. and the molecular mechanism against breast cancer. Sci. Rep. 10, 15730 (2020)

    Google Scholar 

  42. C. Yuan, M.H. Wang, F. Wang, P.Y. Chen, X.G. Ke, B. Yu, Y.F. Yang, P.T. You, H.Z. Wu, Network pharmacology and molecular docking reveal the mechanism of Scopoletin against non-small cell lung cancer. Life Sci. 270, 119105 (2021)

    Article  CAS  PubMed  Google Scholar 

  43. A.L. Yang, Q. Wu, Z.D. Hu, S.P. Wang, Y.F. Tao, A.M. Wang, Y.X. Sun, X.L. Li, L. Dai, J. Zhang, A network pharmacology approach to investigate the anticancer mechanism of cinobufagin against hepatocellular carcinoma via downregulation of EGFR-CDK2 signaling. Toxicol. Appl. Pharmacol. 431, 115739 (2021)

    Article  CAS  PubMed  Google Scholar 

  44. L. Min, Y. Wu, G. Cao, D. Mi, C. Chen, A network pharmacology strategy to investigate the anti-osteoarthritis mechanism of main lignans components of Schisandrae Fructus. Int. Immunopharmacol. 98, 107873 (2021)

    Article  CAS  PubMed  Google Scholar 

  45. Q. Gao, D. Tian, Z. Han, J. Lin, Z. Chang, D. Zhang, D. Ma, Network pharmacology and molecular docking analysis on molecular targets and mechanisms of Buyang Huanwu decoction in the treatment of Ischemic Stroke. Evid. Based Complement. Alternat. Med. 2021, 8815447 (2021)

    Article  PubMed  PubMed Central  Google Scholar 

  46. Z. Chen, T. Lin, X. Liao, Z. Li, R. Lin, X. Qi, G. Chen, L. Sun, L. Lin, Network pharmacology based research into the effect and mechanism of Yinchenhao decoction against Cholangiocarcinoma. Chin. Med. 16, 13 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. M. Tang, X. **e, P. Yi, J. Kang, J. Liao, W. Li, F. Li, Integrating network pharmacology with molecular docking to unravel the active compounds and potential mechanism of Simiao Pill treating Rheumatoid Arthritis. Evid. Based Complement. Alternat. Med. 2020, 5786053 (2020)

    Article  PubMed  PubMed Central  Google Scholar 

  48. Z. Huang, X. Shi, X. Li, L. Zhang, P. Wu, J. Mao, R. **ng, N. Zhang, P. Wang, Network pharmacology approach to uncover the mechanism governing the effect of Simiao powder on Knee Osteoarthritis. Biomed. Res. Int. 2020, 6971503 (2020)

    Article  PubMed  PubMed Central  Google Scholar 

  49. X. Liao, Y. Bu, Q. Jia, Traditional Chinese medicine as supportive care for the management of liver cancer: past, present, and future. Genes Dis. 7, 370–379 (2020)

    Article  CAS  PubMed  Google Scholar 

  50. S. He, C. Zhang, P. Zhou, X. Zhang, T. Ye, R. Wang, G. Sun, X. Sun, Herb-induced liver injury: phylogenetic relationship, structure-toxicity relationship, and herb-ingredient network analysis. Int. J. Mol. Sci. 20 (2019)

    Google Scholar 

  51. Y.Y. Wang, J. Li, Z.R. Wu, B. Zhang, H.B. Yang, Q. Wang, Y.C. Cai, G.X. Liu, W.H. Li, Y. Tang, Insights into the molecular mechanisms of Polygonum multiflorum Thunb-induced liver injury: a computational systems toxicology approach. Acta Pharmacol. Sin. 38, 719–732 (2017)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Z.J. Zhuang, T. Lin, L.X. Luo, W.X. Zhou, J.M. Wen, H.F. Huang, Z.H. Liu, L.Z. Lin, Exploring the mechanism of aidi injection for lung cancer by network pharmacology approach and molecular docking validation. Bioscience Reports 41 (2021)

    Google Scholar 

  53. H. Xu, Y. Zhang, P. Wang, J. Zhang, H. Chen, L. Zhang, X. Du, C. Zhao, D. Wu, F. Liu, H. Yang, C. Liu, A comprehensive review of integrative pharmacology-based investigation: A paradigm shift in traditional Chinese medicine. Acta pharmaceutica Sinica. B 11, 1379–1399 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. N.Q. Zhu, J.Y. Hou, G.Y. Ma, J.X. Liu, Network pharmacology identifies the mechanisms of action of Shaoyao Gancao Decoction in the treatment of Osteoarthritis medical science monitor. Int. Med. J. Exp. Clin. Res. 25, 6051–6073 (2019)

    CAS  Google Scholar 

  55. J.H. Zuo, H.B. Ye, H. Lin, G.F. Lv, Y.C. Wang, X.W. Huang, Z. Lin, Study on the antipyretic mechanism of baihu decoction: network pharmacology prediction and experimental verification. J. Biobased Mater. Bioenergy 15, 334–341 (2021)

    Article  CAS  Google Scholar 

  56. S. Sigismund, D. Avanzato, L. Lanzetti, Emerging functions of the EGFR in cancer. Mol. Oncol. 12, 3–20 (2018)

    Article  PubMed  Google Scholar 

  57. R.S. Apte, D.S. Chen, N. Ferrara, VEGF in signaling and disease: beyond discovery and development. Cell 176, 1248–1264 (2019)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. B. Dong, C. Peng, P. Ma, X. Li, An integrated strategy of MS-network-based offline 2DLC-QTOF-MS/MS coupled with UHPLC-QTRAP®-MS/MS for the characterization and quantification of the non-polysaccharides in Sijunzi decoction. Anal. Bioanal. Chem. 413, 3511–3527 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. F. **a, C. Liu, J.B. Wan, Characterization of the cold and hot natures of raw and processed Rehmanniae Radix by integrated metabolomics and network pharmacology. Phytomed.: Int. J. Phytotherapy Phytopharmacol. 74, 153071 (2020)

    Article  CAS  Google Scholar 

  60. Y.L. Bai, J.F. Zhang, Z.J. Sha, N. Zhu, X.L. Huang, Z.Y. Li, Study on potential molecular mechanism of Mongolian medicine Bawei Sanxiang San in treatment of chronic heart failure based on network pharmacology and molecular docking. Zhongguo Zhong Yao Za Zhi 46, 2392–2402 (2021)

    PubMed  Google Scholar 

  61. J. van den Anker, M.D. Reed, K. Allegaert, G.L. Kearns, Developmental changes in Pharmacokinetics and Pharmacodynamics. J. Clin. Pharmacol. 58(Suppl 10), S10–S25 (2018)

    Google Scholar 

  62. L. Zhang, Y. **ao, R. Yang, S. Wang, S. Ma, J. Liu, W. **ao, Y. Wang, Systems pharmacology to reveal multi-scale mechanisms of traditional Chinese medicine for gastric cancer. Sci. Rep. 11, 22149 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. F.X. Zhang, Z.T. Li, X. Yang, Z.N. **e, M.H. Chen, Z.H. Yao, J.X. Chen, X.S. Yao, Y. Dai, Discovery of anti-flu substances and mechanism of Shuang-Huang-Lian water extract based on serum pharmaco-chemistry and network pharmacology. J. Ethnopharmacol. 268, 113660 (2021)

    Article  CAS  PubMed  Google Scholar 

  64. Y. Yin, K. Zhang, L. Wei, D. Chen, Q. Chen, M. Jiao, X. Li, J. Huang, Z. Gong, N. Kang, F. Li, The molecular mechanism of antioxidation of Huolisu oral liquid based on serum analysis and network analysis. Front. Pharmacol. 12, 710976 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. W. Yang, X. Jiang, J. Liu, D. Qi, Z. Luo, G. Yu, X. Li, M. Sen, H. Chen, W. Liu, Y. Liu, G. Wang, Integrated strategy from In Vitro In Situ, In Vivo to In Silico for predicting active constituents and exploring molecular mechanisms of Tongfengding capsule for treating gout by inhibiting inflammatory responses. Front. Pharmacol. 12, 759157 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. H. Zhi, Z. Zhang, Y. Deng, B. Yan, Z. Li, W. Wu, Z. Feng, M. Lei, H. Long, J. Hou, D. Guo, W. Wu, Restoring perturbed oxylipins with Danqi Tongmai Tablet attenuates acute myocardial infarction. Phytomed.: Int. J. Phytother. Phytopharmacol. 90, 153616 (2021)

    Article  CAS  Google Scholar 

  67. C.X. Liu, S.L. Chen, X.H. **ao, T.J. Zhang, W.B. Hou, M.L. Liao, A new concept on quality marker of Chinese materia medica: quality control for Chinese medicinal products. Chin. Traditional Herbal Drugs 47, 1443–1457 (2016)

    Google Scholar 

  68. Y. Zhang, S. Li, Y. Liang, R. Liu, X. Lv, Q. Zhang, H. Xu, K. Bi, Z. Li, Q. Li, A systematic strategy for uncovering quality marker of Asari Radix et Rhizoma on alleviating inflammation based chemometrics analysis of components. J. Chromatogr. A 1642, 461960 (2021)

    Article  CAS  PubMed  Google Scholar 

  69. D. Xu, J. Wang, W. Chen, X. Yang, J. Zhou, H. Ma, L. Di, J. Duan, Evaluation of analgesic and anti-inflammatory actions of indolealkylamines from toad venom in mice using lipidomics and molecular docking. J. Ethnopharmacol. 269, 113677 (2021)

    Article  CAS  PubMed  Google Scholar 

  70. L. Wu, Q. Zhang, W. Liang, Y. Ma, L. Niu, L. Zhang, Phytochemical analysis using UPLC-MS(n) combined with network pharmacology approaches to explore the biomarkers for the quality control of the anticancer Tannin fraction of Phyllanthus emblica L. habitat in Nepal. Evid. Based Complement. Alternat. Med.: eCAM 2021, 6623791 (2021)

    PubMed  PubMed Central  Google Scholar 

  71. B. Yang, N. Yang, Y. Chen, M. Zhu, Y. Lian, Z. **ong, B. Wang, L. Feng, X. Jia, An integrated strategy for effective-component discovery of Astragali Radix in the treatment of lung cancer. Front. Pharmacol. 11, 580978 (2020)

    Article  CAS  PubMed  Google Scholar 

  72. W.L. Wei, Y.L. An, Y.Z. Zhang, Z.W. Li, Y. Zhou, M. Lei, J.Q. Zhang, H. Qu, J. Da, W.Y. Wu, D.A. Guo, Quantitative analysis of fourteen bufadienolides in Venenum Bufonis crude drug and its Chinese patent medicines by ultra-high performance liquid chromatography coupled with tandem mass spectrometry. J. Ethnopharmacol. 251, 112490 (2020)

    Article  CAS  PubMed  Google Scholar 

  73. B.L. Zhang, X.H. Fan, Y. Liu, H.B. Qu, J.H. Zhang, Y.Y. Cheng, Strategy and core technologies for the secondary development of Chinese patent medicine. China J. Chin. Materia Med. 38, 3797–3800 (2013)

    Google Scholar 

  74. X. Zhang, Y. Wang, K. Zhang, H. Sheng, Y. Wu, H. Wu, Y. Wang, J. Guan, Q. Meng, H. Li, Z. Li, G. Fan, Y. Wang, Discovery of tetrahydropalmatine and protopine regulate the expression of dopamine receptor D2 to alleviate migraine from Yuanhu Zhitong formula. Phytomed.: Int. J. Phytother. Phytopharmacol. 91, 153702 (2021)

    Article  CAS  Google Scholar 

  75. H. Zhang, R. Chen, C. Xu, G. Zhang, Y. Guan, Q. Feng, J. Yao, J. Yan, An integrated approach to discriminate the quality markers of traditional Chinese medicine preparation based on multi-dimensional characteristic network: Shenqi Jiangtang Granule as a case. J. Ethnopharmacol. 278, 114277 (2021)

    Article  CAS  PubMed  Google Scholar 

  76. G. Xue, M. Zhu, N. Meng, J. Guan, J. Zhang, J. Yang, Y. Wang, Y. Cui, X. Chai, Integrating study on qualitative and quantitative characterization of the major constituents in Shuanghuanglian injection with UHPLC/Q-Orbitrap-MS and UPLC-PDA. J. Anal. Methods Chem. 2021, 9991363 (2021)

    Article  PubMed  PubMed Central  Google Scholar 

  77. B. Wang, Z. Wu, J. Wang, W. Li, G. Liu, B. Zhang, Y. Tang, Insights into the mechanism of Arnebia euchroma on leukemia via network pharmacology approach. BMC Complement. Med. Ther. 20, 322 (2020)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. R. Yang, H. Liu, C. Bai, Y. Wang, X. Zhang, R. Guo, S. Wu, J. Wang, E. Leung, H. Chang, P. Li, T. Liu, Y. Wang, Chemical composition and pharmacological mechanism of Qingfei Paidu decoction and Ma **ng Shi Gan decoction against coronavirus disease 2019 (COVID-19): In silico and experimental study. Pharmacol. Res. 157, 104820 (2020)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Y. Gao, K.X. Wang, P. Wang, X. Li, J.J. Chen, B.Y. Zhou, J.S. Tian, D.G. Guan, X.M. Qin, A.P. Lu, A novel network pharmacology strategy to decode mechanism of Lang Chuang Wan in treating Systemic Lupus Erythematosus. Front. Pharmacol. 11, 512877 (2020)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. J. Li, Y. Huang, S. Zhao, Q. Guo, J. Zhou, W. Han, Y. Xu, Based on network pharmacology to explore the molecular mechanisms of astragalus membranaceus for treating T2 diabetes mellitus. Annals Transl. Med. 7, 633 (2019)

    Article  CAS  Google Scholar 

  81. L. He, H. Jiang, T. Lan, Y. Qiu, K. Yang, K. Chen, X. Yao, Z. Yao, W. Lu, Chemical profile and potential mechanisms of Huo-Tan-Chu-Shi decoction in the treatment of coronary heart disease by UHPLC-Q/TOF-MS in combination with network pharmacology analysis and experimental verification. J. Chromatogr. B, Anal. Technol. Biomed. Life Sci. 1175, 122729 (2021)

    Article  CAS  Google Scholar 

  82. Y. Xu, J. Huang, N. Wang, H.Y. Tan, C. Zhang, S. Li, G. Tang, Y. Feng, Network pharmacology-based analysis and experimental exploration of antidiabetic mechanisms of Gegen Qinlian decoction. Front. Pharmacol. 12, 649606 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. H. Nie, Y. Deng, C. Zheng, M. Pan, J. **e, Y. Zhang, Q. Yang, A network pharmacology-based approach to explore the effects of Chaihu Shugan powder on a non-alcoholic fatty liver rat model through nuclear receptors. J. Cell Mol. Med. 24, 5168–5184 (2020)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. J. Deng, Z. Wu, C. Chen, Z. Zhao, Y. Li, Z. Su, Y. Lin, Y. Wang, Z. Wang, Chinese Medicine Huzhen Tongfeng formula effectively attenuates Gouty Arthritis by inhibiting arachidonic acid metabolism and inflammatory mediators. Mediators Inflamm. 2020, 6950206 (2020)

    Article  PubMed  PubMed Central  Google Scholar 

  85. L. Wang, H. Wu, Y. Deng, S. Zhang, Q. Wei, Q. Yang, S. Piao, W. Bei, X. Rong, J. Guo, FTZ Ameliorates diabetic cardiomyopathy by inhibiting inflammation and cardiac fibrosis in the Streptozotocin-induced model. Evid. Based Complement. Alternat. Med.: eCAM 2021, 5582567 (2021)

    PubMed  PubMed Central  Google Scholar 

  86. D. Zhang, B. Liu, X. Jie, J. Deng, Z. Lu, F. Lu, X. Liu, Uncovering Bupi Yishen Formula pharmacological mechanisms against chronic kidney disease by network pharmacology and experimental validation. Front. Pharmacol. 12, 761572 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  87. Z. Zhuang, J. Wen, L. Zhang, M. Zhang, X. Zhong, H. Chen, C. Luo, Can network pharmacology identify the anti-virus and anti- inflammatory activities of Shuanghuanglian oral liquid used in Chinese medicine for respiratory tract infection? Eur. J. Integr. Med. 37, 101139 (2020)

    Article  PubMed  PubMed Central  Google Scholar 

  88. J. Zhao, S. Tian, D. Lu, J. Yang, H. Zeng, F. Zhang, D. Tu, G. Ge, Y. Zheng, T. Shi, X. Xu, S. Zhao, Y. Yang, W. Zhang, Systems pharmacological study illustrates the immune regulation, anti-infection, anti-inflammation, and multi-organ protection mechanism of Qing-Fei-Pai-Du decoction in the treatment of COVID-19. Phytomed.: Int. J. Phytother. Phytopharmacol. 85, 153315 (2021)

    Article  CAS  Google Scholar 

  89. S. Zheng, J.P. Baak, S. Li, W. **ao, H. Ren, H. Yang, Y. Gan, C. Wen, Network pharmacology analysis of the therapeutic mechanisms of the traditional Chinese herbal formula Lian Hua Qing Wen in Corona virus disease 2019 (COVID-19), gives fundamental support to the clinical use of LHQW. Phytomed.: Int. J. Phytother. Phytopharmacol. 79, 153336 (2020)

    Article  CAS  Google Scholar 

  90. M.X. Yu, X. Song, X.Q. Ma, C.X. Hao, J.J. Huang, W.H. Yang, Investigation into molecular mechanisms and high-frequency core TCM for pulmonary fibrosis secondary to COVID-19 based on network pharmacology and data mining. Annals Palliative Med. 10, 3960–3975 (2021)

    Article  Google Scholar 

  91. Z. Wang, L. Li, M. Song, J. Yan, J. Shi, Y. Yao, Evaluating the traditional chinese medicine (TCM) officially recommended in China for COVID-19 using ontology-based side-effect prediction framework (OSPF) and deep learning. J. Ethnopharmacol. 272, 113957 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  92. X. Wang, Y. Gao, Y. Tian, X. Liu, G. Zhang, Q. Wang, W. **e, K. Liu, Q. Qian, Q. Wang, Integrative serum metabolomics and network analysis on mechanisms exploration of Ling-Gui-Zhu-Gan Decoction on doxorubicin-induced heart failure mice. J. Ethnopharmacol. 250, 112397 (2020)

    Article  CAS  PubMed  Google Scholar 

  93. W.N. Zhang, L. Yang, S.S. He, X.M. Qin, A.P. Li, Metabolomics coupled with integrative pharmacology reveal the protective effect of FangjiHuangqi decoction against adriamycin-induced rat nephropathy model. J. Pharm. Biomed. Anal. 174, 525–533 (2019)

    Article  CAS  PubMed  Google Scholar 

  94. Y.Q. Wang, S.J. Li, Y.H. Man, G. Zhuang, Serum metabonomics coupled with HPLC-LTQ/orbitrap MS and multivariate data analysis on the ameliorative effects of Bidens bipinnata L. in hyperlipidemic rats. J. Ethnopharmacol. 262, 113196 (2020)

    Google Scholar 

  95. P.Y. Ge, Y.Y. Qi, S.Y. Qu, X. Zhao, S.J. Ni, Z.Y. Yao, R. Guo, N.Y. Yang, Q.C. Zhang, H.X. Zhu, Potential mechanism of S. baicalensis on lipid metabolism explored via network pharmacology and utargeted Lipidomics. Drug Des. Dev. Ther. 15, 1915–1930 (2021)

    Google Scholar 

  96. T. Xu, P. Wang, X. Zheng, Z. Yan, K. Li, J. Xu, C. Jiang, F. Zhu, The therapeutic effects and mechanisms of Long Chai Fang on chronic hepatitis B. Annals Transl. Med. 9, 865 (2021)

    Article  CAS  Google Scholar 

  97. S. Ma, L. Zheng, X. Lin, Y. Feng, M. Yang, L. Shen, Network pharmacology and metabolomics studies on antimigraine mechanisms of Da Chuan **ong Fang (DCXF). Evid. Based Complement. Alternat. Med.: eCAM 2021, 6665137 (2021)

    Article  PubMed  PubMed Central  Google Scholar 

  98. H. Fang, A. Zhang, X. Zhou, J. Yu, Q. Song, X. Wang, High-throughput metabolomics reveals the perturbed metabolic pathways and biomarkers of Yang Huang syndrome as potential targets for evaluating the therapeutic effects and mechanism of geniposide. Front. Med. 14, 651–663 (2020)

    Article  PubMed  Google Scholar 

  99. S.Y. Qu, X.Y. Li, X. Heng, Y.Y. Qi, P.Y. Ge, S.J. Ni, Z.Y. Yao, R. Guo, N.Y. Yang, Y. Cao, Q.C. Zhang, H.X. Zhu, Analysis of antidepressant activity of Huang-Lian Jie-Du decoction through network pharmacology and metabolomics. Front. Pharmacol. 12, 619288 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  100. X. Bai, Y. Tang, Q. Li, Y. Chen, D. Liu, G. Liu, X. Fan, R. Ma, S. Wang, L. Li, K. Zhou, Y. Zheng, Z. Liu, Network pharmacology integrated molecular docking reveals the bioactive components and potential targets of Morinda officinalis-Lycium barbarum coupled-herbs against oligoasthenozoospermia. Sci. Rep. 11, 2220 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. N.J. Yang, Y.R. Liu, Z.S. Tang, J.A. Duan, Y.F. Yan, Z.X. Song, M.G. Wang, Y.R. Zhang, B.J. Chang, M.L. Zhao, Y.T. Zhao, Poria cum Radix Pini Rescues barium chloride-induced Arrhythmia by regulating the cGMP-PKG signalling pathway involving ADORA1 in Zebrafish. Front. Pharmacol. 12, 688746 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  102. J. Wei, F. Guo, M. Zhang, M. **an, T. Wang, J. Gao, H. Wu, L. Song, Y. Zhang, D. Li, H. Yang, L. Huang, Signature-oriented investigation of the efficacy of multicomponent drugs against heart failure. FASEB J.: Official Publ. Federation Am. Soc. for Exp. Biol. 33, 2187–2198 (2019)

    Article  CAS  Google Scholar 

  103. W. **ang, Z. Long, J. Zeng, X. Zhu, M. Yuan, J. Wu, Y. Wu, L. Liu, Mechanism of Radix Rhei Et Rhizome intervention in cerebral infarction: a research based on chemoinformatics and systematic pharmacology. Evid. Based Complement. Alternat. Med.: eCAM 2021, 6789835 (2021)

    Article  PubMed  PubMed Central  Google Scholar 

  104. J. Chen, P. Dou, H. **ao, D. Dou, X. Han, H. Kuang, Application of proteomics and metabonomics to reveal the molecular basis of Atractylodis Macrocephalae Rhizome for ameliorating hypothyroidism instead of hyperthyroidism. Front. Pharmacol. 12, 664319 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  105. C. Krittanawong, H. Zhang, Z. Wang, M. Aydar, T. Kitai, Artificial intelligence in precision cardiovascular medicine. J. Am. Coll. Cardiol. 69, 2657–2664 (2017)

    Article  PubMed  Google Scholar 

  106. D. Wang, S. Zeng, C. Xu, W. Qiu, Y. Liang, T. Joshi, D. Xu, MusiteDeep: a deep-learning framework for general and kinase-specific phosphorylation site prediction. Bioinformatics 33, 3909–3916 (2017)

    Article  PubMed  PubMed Central  Google Scholar 

  107. H. Yang, M. Wang, X. Liu, X.M. Zhao, A. Li, PhosIDN: an integrated deep neural network for improving protein phosphorylation site prediction by combining sequence and protein-protein interaction information. Bioinformatics 37, 4668–4676 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  108. W. Zhou, K. Yang, J. Zeng, X. Lai, X. Wang, C. Ji, Y. Li, P. Zhang, S. Li, FordNet: recommending traditional Chinese medicine formula via deep neural network integrating phenotype and molecule. Pharmacol. Res. 173, 105752 (2021)

    Article  CAS  PubMed  Google Scholar 

  109. X. Ren, T. He, J. Wang, L. Wang, Y. Wang, X. Liu, Y. Dong, J. Ma, J. Jia, R. Song, Q. Fan, J. Wei, A. Yu, X. Wang, G. She, UV spectroscopy and HPLC combined with chemometrics for rapid discrimination and quantification of Curcumae Rhizoma from three botanical origins. J. Pharm. Biomed. Anal. 202, 114145 (2021)

    Article  CAS  PubMed  Google Scholar 

  110. X. Li, X. Guo, M. Sha, W. Gao, X. Li, Combining network pharmacology with chromatographic fingerprinting and multi-component quantitative analysis for the quality evaluation of Astragali Radix. Biomed. Chromatogr. e5319 (2022)

    Google Scholar 

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Authors and Affiliations

  1. State Key Laboratory of Component-Based Chinese Medicine, Tian** University of Traditional Chinese Medicine, Tian**, 301617, China

    Kunze Du, Chunxiao Liang & Yanxu Chang

  2. Tian** Key Laboratories of Phytochemistry and Pharmaceutical Analysis, Tian** University of Traditional Chinese Medicine, Tian**, 301617, China

    Kunze Du, Chunxiao Liang & Yanxu Chang

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  1. Kunze Du
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  1. State Key Laboratory of Quality Research in Chinese Medicine and Macao Centre for Testing of Chinese Medicine, University of Macau, Macau, China

    Shao** Li

  2. State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau, China

    **g Zhao

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This review was supported by National Natural Science Foundation of China (81973704).

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Du, K., Liang, C., Chang, Y. (2024). Network Pharmacology to Clarify the Effective Substances and Their Action Mechanisms of Traditional Chinese Medicines. In: Li, S., Zhao, J. (eds) Quality Control of Chinese Medicines . Springer, Singapore. https://doi.org/10.1007/978-981-99-9871-5_6

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