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Role of Exosomes in Management of Depression

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Exosomes Based Drug Delivery Strategies for Brain Disorders

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Abstract

Depression or major depressive disorder (MDD) is a disease that is characterized by prolonged sad mood. In most of the cases, the disorder is presented with other comorbid illnesses such as anxiety, Alzheimer’s disease (AD), obesity, and diabetes. Most of the drugs used for the treatment are targeting the levels of monoamines, namely serotonin, dopamine, and norepinephrine in the synapse. Most of the drugs showed their effect after 4–6 weeks of treatment as they are working via modification of receptors. In addition, adverse effects, treatment resistance, and poor outcomes of the available treatment have urged the need for novel and promising therapeutic options. Exosomes are extracellular vesicles (EVs) of endocytic origin. These vesicles are secreted or released by cells and found in bio-fluids such as urine, plasma, and saline. These vesicles are having a role in various vital processes of the body and are made up of small RNA, DNA, and proteins. These vesicles may play an important role in various physiological processes such as cell-to-cell communication, neurogenesis, and synaptic plasticity. One of the important advantages of exosomes is that they are able to cross blood–brain barrier (BBB). Moreover, exosomes are capable of transferring DNA, protein, mRNAs, and miRNAs to recipient cells. This chapter enlightens the potential role of exosomes in MDD and their utilization as a therapeutic option or diagnostic tool for depression.

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Authors and Affiliations

  1. School of Health Sciences and Technology, Dr. Vishwanath Karad MIT World Peace University, Pune, India

    Aryaa Nigade, Gauri Pathak & Shvetank Bhatt

  2. Department of Pharmacology, School of Pharmacy & Technology Management (SPTM), SVKM’s Narsee Monjee Institute of Management Studies (NMIMS), Shirpur, India

    K. Anitha

  3. Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University Madhya Pradesh, Gwalior, Madhya Pradesh, India

    Neeraj Mishra

  4. Kusum Healthcare Private Limited, New Delhi, India

    Vikas Bali

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  1. Aryaa Nigade
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  2. Gauri Pathak
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  3. K. Anitha
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  4. Neeraj Mishra
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  5. Vikas Bali
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  6. Shvetank Bhatt
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Editors and Affiliations

  1. Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University Madhya Pradesh, Gwalior, Madhya Pradesh, India

    Neeraj Mishra

  2. Department of Pharmaceutical Sciences, Bengal College of Pharmaceutical Sciences & Research, Durgapur, West Bengal, India

    Sumel Ashique

  3. Department of Pharmaceutics, Guru Ramdas Khalsa Institute, Jabalpur, Madhya Pradesh, India

    Ashish Garg

  4. University of Michigan Medical Center, Ann Arbor, MI, USA

    Vadivalagan Chithravel

  5. Department of Chemical Pathology, School of Pathology, University of the Free State (Bloemfontein Campus), Bloemfontein, Free State, South Africa

    Krishnan Anand

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Nigade, A., Pathak, G., Anitha, K., Mishra, N., Bali, V., Bhatt, S. (2024). Role of Exosomes in Management of Depression. In: Mishra, N., Ashique, S., Garg, A., Chithravel, V., Anand, K. (eds) Exosomes Based Drug Delivery Strategies for Brain Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-99-8373-5_8

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