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Pathology and Pathophysiology of Surgical Spleen Diseases

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Laparoscopic Surgery of the Spleen

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Abstract

The function of spleen is closely related to the occurrence, development, and outcome of various blood system diseases. Splenectomy is also an effective method to treat or alleviate these diseases [1]. For hemolytic anemia diseases such as autoimmune hemolytic anemia (AIHA), hereditary spherocytosis, thalassemia, pyruvate kinase deficiency, and so on, spleen is the main place to destroy the abnormal red blood cells, and some selected patients could benefit from splenectomy; for hemorrhagic diseases such as immune thrombocytopenia (ITP), spleen is considered to be the main site of producing platelet-associated antibodies (PAIgG) and the main organ of platelet retention and destruction, and splenectomy as a second-line treatment can also achieve good results [2]; for malignant hematologic diseases such as Hodgkin’s lymphoma, splenectomy is helpful for diagnosis and clinical stage. For primary lymphoma of the spleen as another example, such as follicular lymphoma, mantle cell lymphoma, and marginal area lymphoma, the 5-year survival rate can reach more than 30% via comprehensive treatment based on splenectomy [3]. In a word, spleen surgery is closely related to the clinical treatment of hematologic diseases. The following is a brief overview of the pathology and pathophysiology of spleen in AIHA, ITP, lymphoma, and other blood diseases.

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Authors and Affiliations

  1. West China Hospital, Sichuan University, Chengdu, China

    He Cai, Junhe Gou & Bing Peng

  2. West China Second University Hospital, Sichuan University, Chengdu, China

    Qijun Chen

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  1. He Cai
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  2. Junhe Gou
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  1. HPB Minimally Invasive Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China

    Bing Peng

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Cai, H., Gou, J., Chen, Q., Peng, B. (2021). Pathology and Pathophysiology of Surgical Spleen Diseases. In: Peng, B. (eds) Laparoscopic Surgery of the Spleen. Springer, Singapore. https://doi.org/10.1007/978-981-16-1216-9_3

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  • DOI: https://doi.org/10.1007/978-981-16-1216-9_3

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