Abstract
G-POEM is a submucosal endoscopic technique allowing pyloromyotomy and following the concept of esophageal POEM. G-POEM allows endoscopic management of gastroparesis secondary to the following etiologies: postoperative, diabetes, autoimmune, and idiopathic which is the main cause. The procedure includes a short tunnel (5 cm length), reaching the pyloric sphincter which appears as a white submucosal arch, and the pyloromyotomy. Results are assessed according to clinical efficacy (GSCI) score and gastric emptying scintigraphy. They showed at 6 months follow-up a mean clinical success in 82% and mean GES improvement in 72%. Adverse events are not frequent with a 6% mean rate and could be managed conservatively.
G-POEM offers to patients with gastroparesis an efficient minimally invasive approach. The association with external pacemaker should be investigated looking to the pathophysiological pathway of gastroparesis.
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References
Hasler WL. Gastroparesis: symptoms, evaluation, and treatment. Gastroenterol Clin N Am. 2007;36:619–47, ix
Parkman HP, Hasler WL, Fisher RS. American Gastroenterological Association technical review on the diagnosis and treatment of gastroparesis. Gastroenterology. 2004;127:1592–622.
Soykan I, Sivri B, Sarosiek I, et al. Demography, clinical characteristics, psychological and abuse profiles, treatment, and long-term follow-up of patients with gastroparesis. Dig Dis Sci. 1998;43:2398–404.
Rao AS, Camilleri M. Review article: metoclopramide and tardive dyskinesia. Aliment Pharmacol Ther. 2010;31:11–9.
Maganti K, Onyemere K, Jones MP. Oral erythromycin and symptomatic relief of gastroparesis: a systematic review. Am J Gastroenterol. 2003;98:259–63.
Dumitrascu DL, Weinbeck M. Domperidone versus metoclopramide in the treatment of diabetic gastroparesis. Am J Gastroenterol. 2000;95:316–7.
Arts J, Holvoet L, Caenepeel P, et al. Clinical trial: a randomized-controlled crossover study of intrapyloric injection of botulinum toxin in gastroparesis. Aliment Pharmacol Ther. 2007;26:1251–8.
Ezzeddine D, Jit R, Katz N, et al. Pyloric injection of botulinum toxin for treatment of diabetic gastroparesis. Gastrointest Endosc. 2002;55:920–3.
Bromer MQ, Friedenberg F, Miller LS, et al. Endoscopic pyloric injection of botulinum toxin A for the treatment of refractory gastroparesis. Gastrointest Endosc. 2005;61:833–9.
Miller LS, Szych GA, Kantor SB, et al. Treatment of idiopathic gastroparesis with injection of botulinum toxin into the pyloric sphincter muscle. Am J Gastroenterol. 2002;97:1653–60.
Friedenberg FK, Palit A, Parkman HP, et al. Botulinum toxin A for the treatment of delayed gastric emptying. Am J Gastroenterol. 2008;103:416–23.
Ukleja A, Tandon K, Shah K, et al. Endoscopic botox injections in therapy of refractory gastroparesis. World J Gastrointest Endosc. 2015;7:790–8.
Coleski R, Anderson MA, Hasler WL. Factors associated with symptom response to pyloric injection of botulinum toxin in a large series of gastroparesis patients. Dig Dis Sci. 2009;54:2634–42.
Clarke JO, Sharaiha RZ, Kord Valeshabad A, et al. Through-the-scope transpyloric stent placement improves symptoms and gastric emptying in patients with gastroparesis. Endoscopy. 2013;45(Suppl 2):E189–90.
Kashab MA, Besharati S, Ngamruengphong S, et al. Refractory gastroparesis can be successfully managed with endoscopic transpyloric stent placement and fixation. Gastrointest Endosc. 2015;82:1106–9.
Toro JP, Lytle NW, Patel AD, et al. Efficacy of laparoscopic pyloroplasty for the treatment of gastroparesis. J Am Coll Surg. 2014;218:652–60.
Hibbard ML, Dunst CM, Swanström LL. Laparoscopic and endoscopic pyloroplasty for gastroparesis results in sustained symptom improvement. J Gastrointest Surg. 2011;15:1513–9.
Abell T, McCallum R, Hocking M, et al. Gastric electrical stimulation for medically refractory gastroparesis. Gastroenterology. 2003;125:421–8.
van der Voort IR, Becker JC, Dietl KH, et al. Gastric electrical stimulation results in improved metabolic control in diabetic patients suffering from gastroparesis. Exp Clin Endocrinol Diabetes. 2005;113:38–42.
Levinthal DJ, Bielefeldt K. Systematic review and meta-analysis: gastric electrical stimulation for gastroparesis. Auton Neurosci. 2017;202:45–55.
Richmond B, Chong B, Modak A, et al. Gastric electrical stimulation for refractory gastroparesis: predictors of response and redefining a successful outcome. Am Surg. 2015;81:467–71.
Lal N, Livemore S, Dunne D, et al. Gastric electrical stimulation with the Enterra system: a systematic review. Gastroenterol Res Pract. 2015;2015:762972.
Camilleri M. Novel diet, drugs, and gastric interventions for gastroparesis. Clin Gastroenterol Hepatol. 2016;14:1072–80.
Gonzalez JM, Benezech A, Vitton V, et al. G-POEM with antro-pyloromyotomy for the treatment of refractory paresis: mid-term, follow-up and factors predicting outcome. Aliment Pharmacol Ther. 2017;46:364–70.
Kashab MA, Ngamruengphong S, Carr-Locke D, et al. Gastric per-oral endoscopic myotomy for refactory paresis: results from the first multicenter study on pyloric myotomy (with video). Gastrointest Endosc. 2017;85:123–8.
Kahaleh M, Gonzalez JM, Xu MM, et al. Gastric peroral endoscopic myotomy for the treatment of refractory gastroparesis: a multicenter international experience. Endoscopy. 2018;50(11):1053–8. Epub ahead of print
Revicki DA, Camilleri M, Kuo B, et al. Development and content validity of a gastroparesis cardinal symptom index daily diary. Aliment Pharmacol Ther. 2009;30(6):670–80.
Coleski R, Baker JR, Hasler WL. Endoscopic gastric food retention in relation to scintigraphic gastric emptying delays and clinical factors. Dig Dis Sci. 2016;61:2593–601.
Sachdeva P, Malhotra N, Pathikonda M, et al. Gastric emptying of solids and liquids for evaluation for gastroparesis. Dig Dis Sci. 2011;56:1138–46.
DiBaise JK, Patel N, Noelting J, et al. The relationship among gastroparetic symptoms, quality of life, and gastric emptying in patients referred for gastric emptying testing. Neurogastroenterol Motil. 2016;28:234–42.
Camilleri M, Iturrino J, Bharucha AE, et al. Performance characteristics of scintigraphic measurement of gastric emptying of solids in healthy participants. Neurogastroenterol Motil. 2012;24:1076–e562.
Szarka LA, Camilleri M. Methods for measurement of gastric motility. Am J Phys. 2009;296:G461–75.
Kuo B, Viazis N, Bahadur S. Non invasive simultaneous measurement of intra-liminal pH and pressure: assessment of gastric emptying and upper GI manometry in healthy subjects. Neurogastroenterol Motil. 2004;16:666.
Shlomovitz E, Pescarus R, Cassera MA, et al. Early human experience with per-oral endoscopic pyloromyotomy (POP). Surg Endosc. 2015;29:543–51.
Dacha S, Mekaroonkamol P, Li L, et al. Oucomes and quality-of-life assessment after gastric per-oral endscopic pyloromyotomy (with video). Gastrointest Endosc. 2017;86:282–9.
Xue H, Fan H, Meng X, et al. Fluoroscopy-guided gastric per-oral endoscopic pyloromyotomy (G-POEM): a more reliable and efficient method for treatment of refractory gastroparesis. Surg Endosc. 2017;31:4617–24.
Khashab MA, Stein E, Clarke JO, et al. Gastric peroral endoscopic myotomy for refractory gastroparesis: first human endoscopic pyloromyotomy (with video). Gastrointest Endosc. 2013;78:764–8.
Gonzalez J-M, Vanbiervliet G, Vitton V, et al. First European human gastric peroral endoscopic myotomy, for treatment of refractory gastroparesis. Endoscopy. 2015;47(Suppl 1):E135–6.
Mearin F, Camilleri M, Malagelada JR. Pyloric dysfunction in diabetics with recurrent nausea and vomiting. Gastroenterology. 1986;90:1919–25.
Inoue H, Minami H, Kobayashi Y, et al. Peroral endoscopic myotomy (POEM) for esophageal achalasia. Endoscopy. 2010;42:265–71.
Gonzalez JM, Lestelle V, Benezech A, et al. Gastric per-oral endoscopic myotomy with antropylormyotomy in the treatment of refractory gastroparesis: clinical experience with follow-up and scintigraphic evaluation (with video). Gastrointest Endosc. 2017;85:123–8.
Wang X-Y, Xu M-D, Yao L-Q, et al. Submucosal tunneling endoscopic resection for submucosal tumors of the esophagogastric junction originating from the muscularis propria layer: a feasibility study (with videos). Surg Endosc. 2014;28:1971–7.
Rodriguez JH, Haskins IN, Strong AT, et al. Per oral endoscopic pyloromyotomy for refractory gastroparesis: initial results from a single institution. Surg Endosc. 2017;31:5381–8.
Mekaroonkamol P, Dacha S, Wang L, et al. Gastric peroral endoscopic pylormyotomy reduces symptoms, increases quality-of-life, and reduces health care usage for patients with gastroparesis. Clin Gastroenterol Hepatol. 2018;17(1):82–9.
Malik Z, Kataria R, Modayil R, et al. Gastric per-oral endoscopic myotomy (G POEM) for the treatment of refractory gastroparesis: early experience. Dig Dis Sci. 2018;63(9):2405–12.
Landreneau JP, Strong AT, El-Hayek K, et al. Laparoscopic pyloroplasty versus endoscopic per-oral pyloromyotomy for the treatment of gastroparesis. Surg Endosc. 2019;33(3):773–81. Epub ahead of print
Camilleri M, McCallum RW, Tack J, et al. Efficacy and safety of relamorelin in diabetics with symptoms of gastroparesis: a randomized, placebo-controlled study. Gastroenterology. 2017;153:1240–50.
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Barthet, M., Gonzalez, J.M. (2021). Gastric Peroral Endoscopic Myotomy: G-POEM. In: Sharma, P., Reddy, N. (eds) Innovations in Gastrointestinal Endoscopy. Springer, Singapore. https://doi.org/10.1007/978-981-15-9247-8_1
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DOI: https://doi.org/10.1007/978-981-15-9247-8_1
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