Abstract
Antibiotic resistance in bacteria is a major health concern. Antimicrobial Peptides (AMPs) are efficient in killing most microbes and yet the development of resistance to AMPs is rare. Although AMPs show promising antimicrobial activities, commercializing them as antibiotics is difficult as in vitro extraction and purification of AMPs is complicated and expensive. AMP mimicking antimicrobial polymers can overcome such problems while maintaining the necessary features of AMPs. Here, we have developed meth-acrylamide based polymers to mimic AMPs which possess high antimicrobial activities with low cytotoxicity. Bactericidal and scanning electron microscopy studies show that the synthesized polymers are effective against Gram-positive and Gram-negative bacteria. We find that these polymers are lethal to bacteria and at the same time, they are also non-cytotoxic to mammalian cells, thereby increasing the potential of these polymers to be used as antibiotics.
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Acknowledgements
We gratefully acknowledge financial support from our collaborator at Texas Tech Health Science Center, Lubbock, Texas, USA and IIT Gandhinagar, India.
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The authors declare that they have no conflict of interest.
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Arora, A., Zheng, W., Liang, H., Mishra, A. (2018). Synthesis of Lysine Mimicking Membrane Active Antimicrobial Polymers. In: Gupta, B., Ghosh, A., Suzuki, A., Rattan, S. (eds) Advances in Polymer Sciences and Technology. Materials Horizons: From Nature to Nanomaterials. Springer, Singapore. https://doi.org/10.1007/978-981-13-2568-7_4
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DOI: https://doi.org/10.1007/978-981-13-2568-7_4
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