Abstract
Late graft dysfunction remains the main cause of graft loss in renal transplantation in spite of improvements in shortterm renal allograft survival and advances in immunosuppressive therapy [1]. Chronic rejection is often an unpredictable outcome in renal transplantation, although many previous publications have tried to identify risk factors [2, 3]. However, most publications have focused on variables in univariate statistical analysis without taking into account potential confounding factors. Both immune and nonimmune mechanisms have been implicated in the pathogenesis of chronic rejection [4], Among the nonimmunological mechanisms, hyperfiltration could be a cause of chronic graft failure [5], although clear human functional data in renal transplantation are lacking.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Matas AJ, Burke JF, Devault GA, Monaco A, Pirsch J. Chronic rejection. J. Am. Soc. Nephrol. 1994; 4: S23–S29.
Almond PS, Matas A, Gillingham K et al. Risk factors for chronic rejection in renal allograft recipients. Transplantation 1993; 55: 752–756.
Riggio RR, Haschemeyer R, Suthanthiran M et al. Predictability of renal allograft failure time in long term survivors: a hypothesis. Transplant. Proc. 1985; 17: 2311–2313.
Massy ZA, Guijarro C, Wiederkehr MR, Ma JZ, Kasiske BL. Chronic renal allograft rejection: immunologic and non immunologic risk factors. Kidney Int. 1996; 49: 518–524.
Terasaki PI, Koyama H, Cecka M, Gjerston D. The hyperfiltration hypothesis in human renal transplantation. Transplantation 1994; 57: 1450–1454.
Paul LC, Häyry P, Foegh M et al. Diagnostic criteria of chronic rejection/accelerated graft atherosclerosis of heart and kidney transplants. Proposal from the Fourth Alexis Carrel Conference on chronic rejection and accelerated arteriosclerosis in transplanted organs. Transplant. Proc. 1993; 25: 2022–2023.
Solez K, Axelsen RA, Benediktsson H et al. International standardization of criteria for the histological diagnosis of renal allograft rejection: the Banff working classification of kidney transplant pathology. Kidney Int. 1993; 44: 411–422.
Cockroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16: 31–41.
Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986; i: 307–310.
Levey AS. Measurement of renal function in chronic renal disease. Kidney Int. 1990; 38: 167–184.
Walser M, Drew HH, Guldan JL. Prediction of glomerular filtration rate from serum creatinine concentration in advanced chronic renal failure. Kidney Int. 1993; 44: 1145–1148.
Modena FM, Hostetter TH, Salahudden AK, Najarian JS, Matas AJ, Rosenberg ME. Progression of kidney disease in chronic renal transplant rejection. Transplantation 1991; 52: 239–244.
Walser M, Drew HH, Lafrance ND. Reciprocal creatinine slopes often give erroneous estimates of progression of chronic renal failure. Kidney Int. 1989; 27: S81-S85.
Nyberg G, Norden G, Svalander C, Blohmé I. Long term renal allograft function. Transpl. Int. 1994; 7: 284–287.
Kasiske BL, Heim-Duthoy KL, Tortorice KL, Rao KV. The variable nature of chronic declines in renal allograft function. Transplantation 1991; 51: 330–334.
Paul LC, Fellström B. Chronic vascular rejection of the heart and the kidney — Have rational treatment options emerged? Transplantation 1992; 53: 1169–1179.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Pouteil-Noble, C., Remontet, L., Lombardo, M., Touraine, J.L., Hadj-Aissa, A., Pozet, N. (1997). Is there any relationship between the early glomerular filtration rate and late graft dysfunction in renal transplantation?. In: Touraine, J.L., Traeger, J., Bétuel, H., Dubernard, J.M., Revillard, J.P., Dupuy, C. (eds) Late Graft Loss. Transplantation and Clinical Immunology, vol 28. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5434-5_4
Download citation
DOI: https://doi.org/10.1007/978-94-011-5434-5_4
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6286-2
Online ISBN: 978-94-011-5434-5
eBook Packages: Springer Book Archive