Abstract
Immunocytochemical and electron-microscopic studies were performed on the central nervous system(CNS) in 10 cases with type I familial amyloid polyneuropathy. All cases showed CNS amyloid deposits, mainly on the leptomeningeal vessels and pia-arachnoid membranes, with arteries and arterioles in subarachnoidal space being the predominant site of cerebral amyloid accumulation. All of these amyloid deposits were specifically immunolabeled by an anti-human prealbumin antibody. However, there were no prealbumin deposits in the brain parenchyma. It is concluded that CNS prealbumin-type amyloid deposition with cerebral amyloid angiopathy is a common pathological finding in this disease.
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© 1991 Springer Science+Business Media Dordrecht
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Ushiyama, M., Ikeda, Si., Yanagisawa, N. (1991). Prealbumin type cerebral amyloid angiopathy in familial amyloid polyneuropathy. In: Natvig, J.B., et al. Amyloid and Amyloidosis 1990. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3284-8_164
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DOI: https://doi.org/10.1007/978-94-011-3284-8_164
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-5450-8
Online ISBN: 978-94-011-3284-8
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