Abstract
Bioactive biopolymers with repeating sequences are often found in nature. Polypeptides usually contain an array of linear repeats, whereas both linear and dendritic repeats are found in polysaccharides. To determine the functional and structural consequences of polypeptides in a dendritic array, we have designed dendritic polypeptides [1] and compared them to the linearly repeating polypeptides. Both series of polypeptides contain two to eight copies of tetrapeptides with BHHB motifs (B = basic amino acid, H = hydrophobic amino acid) derived from naturally occurring antimicrobials.
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© 2001 Springer Science+Business Media Dordrecht
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Lu, YA., Yang, JL., Tam, J.P. (2001). Functional and Structural Comparisons of Linear and Dendritic Arrays of Polypeptides. In: Lebl, M., Houghten, R.A. (eds) Peptides: The Wave of the Future. American Peptide Symposia, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0464-0_218
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DOI: https://doi.org/10.1007/978-94-010-0464-0_218
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-3905-5
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