Abstract
Postnatal development can affect the disposition and pharmacokinetics of drugs in man and animals. Factors such as gastric pH, gastrointestinal motility, mucosal absorbing area, microbial population and milk feeding are major determinants in the absorption process of drugs in the neonate. Postnatal evolution in body composition can lead to important alterations in distribution pattern of drugs in newborns. Differences in maturity at birth and in the rate of postnatal development of the renal and hepatic functions are present in the various species. Therefore, important variations in pharmacokinetics and pharmacodynamics between mammalian newborns can be expected for the same drug.
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De Backer, P. (1986). Comparative neonatal pharmacokinetics. In: Van Miert, A.S.J.P.A.M., Bogaert, M.G., Debackere, M. (eds) Comparative Veterinary Pharmacology, Toxicology and Theraphy. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4153-3_16
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DOI: https://doi.org/10.1007/978-94-009-4153-3_16
Publisher Name: Springer, Dordrecht
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