Abstract
Very little is known on the aetiology of brain tumours of the glioma group. In most cases encountered in the daily neurosurgical pratice, no particular factor of risk is advocated in view of the past history of patients. The ability of radiotherapy to induce glioblastoma has been established (4). Induction of intra-cranial tumours by inoculation of viruses is supported by several reports (1) and the possibility of a transmission of brain gliomas among a population of non blood relative patients has been recently emphasized (7). Since the pioneering work of Zimmerman using methylcholanthrene (10), many chemicals have been suspected as brain carcinogenic agents. Nitrosourea is routinely used in laboratory to induce brain tumours in rats (5, 6, 8). Acrylonitrile has also experimentally been identified as a brain carcinogen (3). Other substances are regarded as potentially carcinogenic without specificity for the human brain. The role of chemicals is supported by a recent epidemiologic study (9) showing an increased risk for brain tumours in certain occupations. The 3 patients that are the subject of this report were managed at our institution during the 6 past years for brain glioma and had in common the fact that they had been working in a similar workplace in a matchbox factory. This clinical experience suggests an environmental risk factor, possibly occupational.
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References
Copeland (D.D.), Vogel (F.S.), Bigner (D.D.): The induction of intra cranial neoplasms by the inoculation of avian sarcoma virus in perinatal and adult rats. J. Neuropathol. Exp. Neurol., 1975, 34, 340–58.
INRS: Produits chimiques carcinogènes pour l’homme. Défmitions. Classement. Cahier de notes documentaires n° 123, 1986, 201–03.
Maltoni (C.), Ciliberti (A.), Dimaio (V.): Carcinogenicity bioassays on rats in acrylonitrile administered by inhalation and ingestion. Med. Sav., 1977, 68, 401–11.
Piatt (J.H.), Blue (J.H.), Schold S.C., Burger (P.C.): Glioblastoma multiforme after radiotherapy from acromegaly. Neurosurgery 1983, 12, 85–9.
Pleven (C.): Survenue élective de glioblastomes lors de la manipulation en laboratoire de recherche des dérivés de la nitrosoguanidine. Press Med., 1984, 37, 13.
Schmider (H.H.), Nielsen (S.L.), Schiller (A.L.), Messer (J.): Morphological studies of rat brain tumours induced by N-nitrosomethylurea. J. Neurosurg., 1971, 34, 335–40.
Siqueira (E.B.), Kranzler (L.I.), Schaffer (L.): Occurence of glioblastoma multiforme in three closely related patients. Surg. Neurol. 1985, 24, 387–91.
Swenberg (J.A.), Koestner (A.), Wechsler (W.): The induction of tumours of the nervous system with intravenous methylnitrosourea. Lab. Invest., 1972, 26, 74–85.
Thomas (T.L.), Waxweiler (R.J.): Brain tumors and occupational risk factors. Scand. J. Work Environ. Health 1986, 12, 1–15.
Zimmerman (H.M.), Arnold (H.): Experimental brain tumors. 1. Tumors produced with methylcholanthrene. Cancer Res., 1941, 1, 919–38.
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© 1987 Martinus Nijhoff Publishers, Dordrecht
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Bret, P., Pialat, J., Robert, H., Deruty, R., Fischer, G., Kzaiz, M. (1987). Chemically Induced Human Gliomas Occurrence of Brain Gliomas in three Matchbox Manufacturers An occupational risk ?. In: Chatel, M., Darcel, F., Pecker, J. (eds) Brain Oncology Biology, diagnosis and therapy. Developments in Oncology, vol 52. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3347-7_41
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DOI: https://doi.org/10.1007/978-94-009-3347-7_41
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