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Signal Transduction in Tumor-Endothelial Cell Communication

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Liver Metastasis: Biology and Clinical Management

Part of the book series: Cancer Metastasis - Biology and Treatment ((CMBT,volume 16))

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Abstract

Metastatic spread is a dreadful complication of neoplastic diseases that is responsible for most deaths due to cancer. It consists of the formation of secondary neoplasms from cancer cells that have detached from the primary site. The formation of these secondary foci is not random and several clinical observations indicate that the metastatic colonization exhibits organ selectivity. This organ tropism relies in part, on the complementary adhesive interactions between the cancer cells and their microenvironment. In particular, several lines of evidence suggest that the organ selectivity of colon cancer cells for the liver involves the attachment of circulating cancer cells to endothelial cell adhesion receptors. The aim of this review is to provide an integrative up-to-date review of the literature on the role of the endothelial-cancer cell interactions in liver colonization by metastatic cells.

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Abbreviations

APC:

adenomatous polyposis coli

BM:

basement membrane

CAMs:

cell adhesion molecules

Cbl:

Casitas B-lineage Lymphoma

CD44:

cluster of differentiation 44

CEA:

carcinoembryonic antigen

c-IAP2:

cellular inhibitor of apoptosis 2

CRC:

colorectal cancer

CRP:

C-reactive protein

CXCR4:

chemokine C-X-C motif receptor 4

DR3:

death receptor-3

ECM:

extracellular matrix

EGF:

epidermal growth factor

EMT:

epithelial mesenchymal transition

ERK:

extracellular-signal regulated kinase

ESL-1:

E-selectin ligand 1

FAK:

focal adhesion kinase

FGF:

fibroblast growth factor

FIP200:

FAK-interacting protein 200

FOXC2:

forkhead box C2

HUVEC:

human umbilical vein endothelial cells

HMGB1:

high-mobility group box 1

CAM-1:

intercellular adhesion molecule-1

IgSFCAMs:

the immunoglobulin superfamily of cell adhesion molecules

IL-3:

interleukin-3

IMD:

integrin-mediated death

IFN γ:

interferon γ

ITAM:

immunoreceptor tyrosine-based activation motif

ITIM:

immunoreceptor tyrosine inhibitory motif

LAMP-1:

lysosomal-associated membrane protein 1

LPS:

lipopolysaccharides

NK cells:

natural killer cells

PDGFR:

platelet-derived growth factor receptor

PECAM-1:

platelet endothelial cell adhesion molecule-1

PI3K:

phosphatidyl inositol 3 kinase

p38 MAPK:

p38 mitogen-activated protein kinase

RGD:

arginine-Glycine-Aspartate

SECs:

sinusoidal endothelial cells

SH2:

Src Homology 2

TGFα:

transforming growth factor alpha

TNF-α:

tumor necrosis factor alpha

TNFR1:

tumor necrosis factor receptor 1

VCAM:

vascular cell adhesion molecule

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Acknowledgements

This work was supported by The Canadian Cancer Society Research Institute. Nicolas Porquet holds a studentship from le Centre de Recherche en Cancérologie de l’Université Laval.

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Authors and Affiliations

  1. Le Centre de recherche en cancérologie de l’Université Laval et le Centre de recherche du CHUQ, L’Hôtel-Dieu de Québec, Québec, QC, Canada

    Nicolas Porquet

  2. Le Centre de recherche en cancérologie de l’Université Laval et le Centre de recherche du CHUQ, L’Hôtel-Dieu de Québec, 9 rue McMahon, Québec, QC, G1R 2J6, Canada

    Jacques Huot

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  1. Nicolas Porquet
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  2. Jacques Huot
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Correspondence to Jacques Huot .

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  1. Royal Victoria Hospital, Division of Surgical Research, McGill University Health Centre, Pine Ave W. 687, Montreal, H3A 1A1, Québec, Canada

    Pnina Brodt

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Porquet, N., Huot, J. (2011). Signal Transduction in Tumor-Endothelial Cell Communication. In: Brodt, P. (eds) Liver Metastasis: Biology and Clinical Management. Cancer Metastasis - Biology and Treatment, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0292-9_7

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