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Engineering and Genetic Approaches to Optimization of Recombinant Fermentation Process

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Biochemical Engineering for 2001

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Abstract

A successful commercial development of gene products requires a good strategy not only for the recombinant DNA cloning but also for a well integrated bioprocess engineering. The bioprocess engineering involves many process steps including: (1) recombinant fermentation and its process optimization, (2) understanding and handling of inclusion body formation and separation, (3) in vitro reactivation and refolding of proteinous gene product, (4) purification and stabilization of the product, and (5) proper formulation and delivery of product for different applications. Among these, the recent advances in recombinant fermentation with a special emphasis on engineering and genetic approaches to optimization of recombinant fermentation process will be focussed in this paper.

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References

  1. Lee, S.B., Dewey D.Y. Ryu, R. S.egel, and S.H. Park. Performance of recombinant fermentation and evaluation of gene expression efficiency for gene product in a two-stage continuous culture system. Biotechnology and Bioengineering 31: 805–820. (1987)

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  2. Hortascu, A. and Dewey D.Y. Ryu, Optimal Temperature Control Policy for a Two-Stage Recombinant Fermentation Process, Biotechnol. Progress, 6: 403–407. (1990)

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  3. Hortascu, A. and Dewey D.Y. Ryu, Optimization of a Two-Stage Recombinant Fermentation Process: The Dilution Rate Effect, Biotechnology Progress. (In Press).

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  4. Dewey D.Y. Ryu and J.Y. Kim, Genetic Improvement and Stabilization of Recombinant Fermentation. Presented at the AIChE Annual Meeting, Los Angeles, CA. (1991)

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Author information

Authors and Affiliations

  1. Department of Chemical Engineering, University of California, Davis, CA, 95616, USA

    Dewey D. Y. Ryu & J. Y. Kim

  2. SUNY, Buffalo, NY, 14260, USA

    Dewey D. Y. Ryu & J. Y. Kim

Authors
  1. Dewey D. Y. Ryu
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  2. J. Y. Kim
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Editor information

Editors and Affiliations

  1. Department of Chemical Engineering, Faculty of Engineering, The University of Tokyo, 3-1 Hongo 7-chome, Bunkyo-ku, Tokyo 113, Japan

    Shintaro Furusaki

  2. The Institute of Physical and Chemical Research, 2-1 Hirosawa, Wako-shi, Saitama, 351-01, Japan

    Isao Endo (Head of Chemical Engineering Laboratory) (Head of Chemical Engineering Laboratory)

  3. Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto, 606-01, Japan

    Ryuichi Matsuno

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© 1992 Springer-Verlag Tokyo

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Ryu, D.D.Y., Kim, J.Y. (1992). Engineering and Genetic Approaches to Optimization of Recombinant Fermentation Process. In: Furusaki, S., Endo, I., Matsuno, R. (eds) Biochemical Engineering for 2001. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68180-9_34

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  • DOI: https://doi.org/10.1007/978-4-431-68180-9_34

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68182-3

  • Online ISBN: 978-4-431-68180-9

  • eBook Packages: Springer Book Archive

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