Summary
The retention behavior of rat blood platelets on poly(2-hydroxyethyl methacrylate) (PHEMA) derivatives with various types of amino groups was investigated. Blood platelet retention on amino-containing PHEMA surfaces was found to be mainly driven through electrostatic interaction, as indicated by results obtained when the surrounding pH was changed. Of interest, platelet retention was dramatically minimized on surfaces with small but definite amounts of cationic groups. This minimum retention of platelets cannot be explained only by electrostatic interaction; it might be due to the reduced contribution of non-electrostatic interaction between platelets and polymer surfaces. Thermal analyses of swollen polymer films showed that water content, especially water content in the free state, was drastically increased by introducing amino groups. This increase in free water content may reduce the contribution of non-electrostatic interaction, resulting in minimized platelet retention.
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© 1993 Springer Japan
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Kikuchi, A., Karasawa, M., Kataoka, K., Okuyama, K., Tsuruta, T. (1993). Amino-Containing Polymers as Non-Adsorbable Surface for Platelets. In: Akutsu, T., Koyanagi, H. (eds) Heart Replacement. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67023-0_3
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DOI: https://doi.org/10.1007/978-4-431-67023-0_3
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-67025-4
Online ISBN: 978-4-431-67023-0
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