Summary
Immunosuppressed NMRI-mice (nu/nu) were raised and kept under germ-reduced conditions and fed with a germ-reduced diet (14 animals = controls). For another 14 mice 4 mg of selegiline were admixed to 10 kg of the diet. The 50% survival rate of the latter group was 160% from birth or 220% from the beginning of the study. The survival rate in weeks finally reached 350%, and the aerea under the curve 250%. The last mouse in the control group died at the age of 5 months, 2.5 months after the study was started; the last mouse in the selegiline group died at the age of 14.5 months, 1 year after the beginning of the study.
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References
Birkmayer W, Knoll J, Riederer P, Youdim MB, Hars V, Marton J (1985) Increased life expectancy resulting from addition of L-deprenyl to Madopar treatment in Parkinson’s disease: a longterm study. J Neural Transm 64: 113–127.
Fortmeyer HP (1981) Thymusaplastische Maus (nu/nu), Thymusaplastische Ratte (rnu/rnu): Haltung, Zucht, Versuchsmodelle. Paul Parey, Berlin Hamburg.
Halliwell B (1989) Oxidants and the central nervous system: some fundamental questions. Acta Neurol Scand 126: 23–33.
Knoll J (1989) The pharmacology of selegiline ((—)deprenyl). New aspects. Acta Neurol Scand 126: 83–91.
Kornhuber J, Konradi C, Mack-Burkhard F, Riederer P, Heinsen H, Beckmann H (1989) Ontogenesis of monoamine oxydase-A and-B in the human brain frontal cortex. Brain Res 499: 81–86.
Oldfield FF (1992) Free radicals, dopamine, levodopa and Parkinson’s disease. Free Radic Res Commun 16 [Suppl 1] Abstract 10.3.
Salo PT, Tatton WG (1991) Deprenyl reduces death of motoneurons caused by axotomy. J Neurosci Res 31: 1–7.
Tatton WG, Greenwood CE (1991) Rescue of dying neurons: a new action of deprenyl in MPTP parkinsonism. J Neurosci Res 30: 666–672.
Youdim MBH, Ben-Shachar D, Riederer P (1989) Is Parkinson’s disease a progressive siderosis of substantia nigra resulting in iron and melanin induced neurodegeneration?. Acta Neurol Scand 126: 47–54.
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© 1994 Springer-Verlag
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Freisleben, HJ., Lehr, F., Fuchs, J. (1994). Lifespan of immunosuppressed NMRI-mice is increased by deprenyl. In: Tipton, K.F., Youdim, M.B.H., Barwell, C.J., Callingham, B.A., Lyles, G.A. (eds) Amine Oxidases: Function and Dysfunction. Journal of Neural Transmission, vol 41. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9324-2_29
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DOI: https://doi.org/10.1007/978-3-7091-9324-2_29
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