Summary
Rasagiline [R(+)-N-propargyl-1-aminoindane] is a selective irreversible inhibitor of MAO-B which is not metabolised to amphetamine-like derivatives. Like deprenyl, when given to rats in a dose selective for inhibition of MAO-B, it does not affect striatal extracellular fluid dopamine levels, but when administered chronically (21 days) it increased striatal microdialysate dopamine without reduction in deaminated metabolites. Similarly to deprenyl, rasagiline (10-6M) increased the percentage of tyrosine hydroxylase positive cells in a primary culture of rat fetal mesencephalic cells (6 days in culture). Rasagiline, but not deprenyl, also increased the number of neurons per field in this organotypic culture.
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© 1996 Springer-Verlag/Wien
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Finberg, J.P.M., Lamensdorf, I., Commissiong, J.W., Youdim, M.B.H. (1996). Pharmacology and neuroprotective properties of rasagiline. In: Kuhn, W., Kraus, P., Przuntek, H. (eds) Deprenyl — Past and Future. Journal of Neural Transmission, vol 48. Springer, Vienna. https://doi.org/10.1007/978-3-7091-7494-4_9
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DOI: https://doi.org/10.1007/978-3-7091-7494-4_9
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