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Plastids in apicomplexan parasites

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Origins of Algae and their Plastids

Part of the book series: Plant Systematics and Evolution ((SYSTEMATICS,volume 11))

Abstract

The discovery in malarial and toxoplasmodial parasites of genes normally occurring in the photosynthetic organelle of plants and algae has prompted speculation that these so-called protozoans might harbour a vestigial plastid. The plastid-like parasite genes occur on an extrachromosomal, maternally inherited, 35 kb DNA circle with an architecture reminiscent of plastid genomes. The 35kb genome is distinct from the 6–7 kb linear mitochondrial genome. Localization of the 35kb genome within the parasite cells by high resolution in situ hybridization has identified a multi membrane-bound organelle in which the plastid-like genome resides. Since phylogenetic trees incorporating genes from the 35 kb genome group them within the plastid radiation, we believe that the parasite organelle is a reduced plastid, that is probably no longer photosynthetic. Combined molecular and ultrastructural evidence indicate plastids to be widespread among apicomplexan parasites. The origin and role of the plastid in obligate intracellular parasites is completely unknown. The potential utility of the plastid as a parasite-specific target for therapeutic agents is examined.

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Authors
  1. Geoffrey I. Mcfadden
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  2. Ross F. Waller
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  3. Michael E. Reith
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  4. Naomi Lang-Unnasch
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Editors and Affiliations

  1. Department of Biological Sciences, University of Iowa, Iowa City, USA

    Debashish Bhattacharya

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Mcfadden, G.I., Waller, R.F., Reith, M.E., Lang-Unnasch, N. (1997). Plastids in apicomplexan parasites. In: Bhattacharya, D. (eds) Origins of Algae and their Plastids. Plant Systematics and Evolution, vol 11. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6542-3_14

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