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Assessment of Tissue Oxygenation in the Critically III

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine 2000

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 2000))

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Abstract

Dysoxia is inadequacy of tissue oxygenation, the condition when oxygen levels are so low that mitochondrial respiration can no longer be sustained [1]. It is assumed that tissue dysoxia and oxygen debt are major factors in the development and the propagation of multiple organ failure (MOF) in critically ill patients. Dysoxia is the result of an abnormal relationship between oxygen supply (DO2) and oxygen demand. In order to prevent its occurrence the maintenance of ‘adequate’ mean arterial pressure (MAP), cardiac output, and DO2 are essential goals of therapy. However, the adequacy of these goals is very difficult to define. Ultimately, a normal relationship between DO2 and oxygen demand should be determined at the mitochondrial level. The measurement of tissue bioenergetics would provide a needed gold standard [2]. Several strategies have been tried recently to avoid the development of oxygen debt in intensive care patients. These strategies involve improvement of systemic hemodynamics and oxygen-derived parameters and, more recently, have focused on regional parameters. This chapter presents these strategies and assesses their usefulness in current practice.

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Authors
  1. B. Vallet
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  2. B. Tavernier
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  3. N. Lund
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Editor information

Editors and Affiliations

  1. Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Head Department of Intensive Care) (Head Department of Intensive Care)

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© 2000 Springer-Verlag Berlin Heidelberg

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Vallet, B., Tavernier, B., Lund, N. (2000). Assessment of Tissue Oxygenation in the Critically III. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 2000. Yearbook of Intensive Care and Emergency Medicine, vol 2000. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-13455-9_59

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  • DOI: https://doi.org/10.1007/978-3-662-13455-9_59

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-66830-5

  • Online ISBN: 978-3-662-13455-9

  • eBook Packages: Springer Book Archive

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